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A glimpse into novel acylations and their emerging role in regulating cancer metastasis Huifang ShiWeigang CuiJie Lv Review Open access 05 February 2024 Article: 76
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Intervertebral disc-intrinsic Hedgehog signaling maintains disc cell phenotypes and prevents disc degeneration through both cell autonomous and non-autonomous mechanisms Lei ZhangSiyuan HuJianquan Chen Original Article Open access 03 February 2024 Article: 74
N4-acetylcytidine modifies primary microRNAs for processing in cancer cells Hailong ZhangRunhui LuJianxiu Yu Original Article Open access 03 February 2024 Article: 73
Combinatorial regulation by ERK1/2 and CK1δ protein kinases leads to HIF-1α association with microtubules and facilitates its symmetrical distribution during mitosis Christina ArseniMartina SamiotakiIlias Mylonis Original Article Open access 01 February 2024 Article: 72
Glucosylceramide in bunyavirus particles is essential for virus binding to host cells Zina M. UckeleyMaëva DuboeufPierre-Yves Lozach Original Article Open access 01 February 2024 Article: 71
Mirk/Dyrk1B controls ventral spinal cord development via Shh pathway N. KokkorakisK. DoukaM. Gaitanou Original Article Open access 31 January 2024 Article: 70
SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging Wenxin WeiTian LiYihao Jiang Review Open access 31 January 2024 Article: 69
A novel aminopeptidase N/CD13 inhibitor selectively targets an endothelial form of CD13 after coupling to proteins Giulia AnderluzziMichela GhittiAngelo Corti Original Article Open access 30 January 2024 Article: 68
MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury Haiyan JiangBoya LiuHualin Sun Review Open access 30 January 2024 Article: 67
Correction: Molecular tracking of interactions between progenitor and endothelial cells via Raman and FTIR spectroscopy imaging: a proof of concept of a new analytical strategy for in vitro research Karolina AugustyniakAleksandra PragnacaKamilla Malek Correction Open access 28 January 2024 Article: 66
GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression Hong Soon KangSara A. GrimmAnton M. Jetten Original Article Open access 28 January 2024 Article: 65
Re-expression of epigenetically silenced PTPRR by histone acetylation sensitizes RAS-mutant lung adenocarcinoma to SHP2 inhibition Tingting DuXiaowen HuXiaoguang Chen Original Article 28 January 2024 Article: 64
Targeted mutagenesis in mice via an engineered AsCas12f1 system Peng FanHejun WangTingting Sui Original Article Open access 28 January 2024 Article: 63
Functional role of Ash2l in oxLDL induced endothelial dysfunction and atherosclerosis Zhenghua SuJinghuan WangYi Zhun Zhu Original Article Open access 27 January 2024 Article: 62
α-Synuclein reduces acetylserotonin O-methyltransferase mediated melatonin biosynthesis by microtubule-associated protein 1 light chain 3 beta-related degradation pathway Congcong JiaLulu TianWeidong Le Original Article 27 January 2024 Article: 61
Spatiotemporal modulation of nitric oxide and Notch signaling by hemodynamic-responsive Trpv4 is essential for ventricle regeneration Chunxiao YuXueyu LiRuilin Zhang Original Article Open access 27 January 2024 Article: 60
Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia Chao SuMingxia LiuJie Yang Original Article Open access 27 January 2024 Article: 59
Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes in the transcriptome profile Chrysa FilippopoulouChairini C. ThoméGeorgia Chachami Original Article Open access 27 January 2024 Article: 58
APC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation Dan ZhangQi-Qi NiYa-ping Ye Original Article Open access 27 January 2024 Article: 57
Single cell multi-omics of fibrotic kidney reveal epigenetic regulation of antioxidation and apoptosis within proximal tubule Zhejun ChenLiqing YeShan Mou Original Article Open access 25 January 2024 Article: 56
Ribosomal protein L24 mediates mammalian microRNA processing in an evolutionarily conserved manner Yonat TzurSerafima DubnovHermona Soreq Original Article Open access 23 January 2024 Article: 55
Tumor suppressor let-7 acts as a key regulator for pluripotency gene expression in Muse cells Gen LiShohei WakaoMari Dezawa Original Article Open access 23 January 2024 Article: 54
Substrate promiscuity of Dicer toward precursors of the let-7 family and their 3′-end modifications Gunjan DadhwalHebatallah SamyPascale Legault Original Article Open access 23 January 2024 Article: 53
APOB100 transgenic mice exemplify how the systemic circulation content may affect the retina without altering retinal cholesterol input Nicole El-DarziNatalia MastIrina A. Pikuleva Original Article Open access 22 January 2024 Article: 52
Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration Naoya ShigesadaNaoya ShikadaNoriaki Sasai Original Article Open access 22 January 2024 Article: 51
FOXA2-initiated transcriptional activation of INHBA induced by methylmalonic acid promotes pancreatic neuroendocrine neoplasm progression Chunhua HuMujie YeQiyun Tang Original Article Open access 22 January 2024 Article: 50
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc Chunwang JiaZiqian XiangYuhua Li Original Article Open access 22 January 2024 Article: 49
The guanine nucleotide exchange factor RapGEF2 is required for ERK-dependent immediate-early gene (Egr1) activation during fear memory formation Sunny Zhihong JiangMeishar ShahohaLee E. Eiden Original Article 18 January 2024 Article: 48
Glial cell alterations in diabetes-induced neurodegeneration MarĂa Llorián-SalvadorSonia Cabeza-FernándezAlerie G. de la Fuente Review Open access 18 January 2024 Article: 47
Correction: Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology Anika HeinzeCara SchuldtMarco B. Rust Correction Open access 18 January 2024 Article: 46
Correction: A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis I. BasakH. E. WickyS. M. Hughes Correction Open access 18 January 2024 Article: 45
Restraining of glycoprotein VI- and integrin α2β1-dependent thrombus formation by platelet PECAM1 Natalie J. JoossMarije G. DienderJohan W. M. Heemskerk Original Article Open access 18 January 2024 Article: 44
Mechano-regulation by clathrin pit-formation and passive cholesterol-dependent tubules during de-adhesion Tithi MandalArikta BiswasBidisha Sinha Original Article Open access 13 January 2024 Article: 43
Multiple circulating forms of neprilysin detected with novel epitope-directed monoclonal antibodies Samantha S. M. LingShera LilyannaOi Wah Liew Original Article Open access 13 January 2024 Article: 42
Correction: Chaotic aging: intrinsically disordered proteins in aging-related processes Vladimir D. ManuylovNikolay S. IlyinskyVladimir N. Uversky Correction 13 January 2024 Article: 41
Secrets and lies of host–microbial interactions: MHC restriction and trans-regulation of T cell trafficking conceal the role of microbial agents on the edge between health and multifactorial/complex diseases F. RiaG. DeloguG. Di Sante Review 13 January 2024 Article: 40
Overexpressing lipid raft protein STOML2 modulates the tumor microenvironment via NF-ÎşB signaling in colorectal cancer Hui GongShaojing ChenLishan Fang Original Article Open access 12 January 2024 Article: 39
Epigenetic repression of CHCHD2 enhances survival from single cell dissociation through attenuated Rho A kinase activity Jumee KimEun-Ji KwonHyuk-Jin Cha Original Article Open access 12 January 2024 Article: 38
Early endocannabinoid-mediated depolarization-induced suppression of excitation delays the appearance of the epileptic phenotype in synapsin II knockout mice Nicola ForteAlessandro NicoisLuigia Cristino Original Article 12 January 2024 Article: 37
Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids Bohdan KysilovViktor KuchtiakLadislav Vyklicky Original Article Open access 12 January 2024 Article: 36
Increasing HbA1c is associated with reduced CD8+ T cell functionality in response to influenza virus in a TCR-dependent manner in individuals with diabetes mellitus Katina D. HulmeZhen Wei Marcus TongKirsty R. Short Original Article Open access 12 January 2024 Article: 35
Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction Karli R. LeFortWiramon RungratanawanichByoung-Joon Song Review Open access 12 January 2024 Article: 34
G-quadruplex structural dynamics at MAPK12 promoter dictates transcriptional switch to determine stemness in breast cancer Pallabi SenguptaAnindya DuttaSubhrangsu Chatterjee Original Article 12 January 2024 Article: 33
Splenectomy ameliorates liver cirrhosis by restoring the gut microbiota balance Ye JinMeixin ShiZhaoyang Lu Original Article 12 January 2024 Article: 32
Imaging of brain barrier inflammation and brain fluid drainage in human neurological diseases Serhat V. OkarFrancesca FagianiDaniel S. Reich Review 12 January 2024 Article: 31
Knockdown of NEAT1 prevents post-stroke lipid droplet agglomeration in microglia by regulating autophagy Yongli PanWenqiang XinThorsten R. Doeppner Original Article Open access 12 January 2024 Article: 30
Intracellular calcium links milk stasis to lysosome-dependent cell death during early mammary gland involution Jaekwang JeongJongwon LeeJohn Wysolmerski Original Article Open access 12 January 2024 Article: 29
Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer Vivian Truong JonesRamona Graves-DealBhuminder Singh Original Article Open access 12 January 2024 Article: 28