Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway Jing GaoHuiqing LiuZhihong Liang Original Article Open access 29 May 2024 Article: 241
Disruption of pulmonary microvascular endothelial barrier by dysregulated claudin-8 and claudin-4: uncovered mechanisms in porcine reproductive and respiratory syndrome virus infection Weifeng SunWeixin WuHanchun Yang Original Article Open access 28 May 2024 Article: 240
Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies Susanne J. van VeluwHelene BenvenisteMatthias J. P. van Osch Review Open access 27 May 2024 Article: 239
Targeting NG2 relieves the resistance of BRAF-mutant thyroid cancer cells to BRAF inhibitors Fang SuiGuanjie WangPeng Hou Original Article Open access 25 May 2024 Article: 238
NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1 Mengxue WangFangyuan SunTingting Yang Original Article Open access 25 May 2024 Article: 237
EFHD1 promotes osteosarcoma proliferation and drug resistance by inhibiting the opening of the mitochondrial membrane permeability transition pore (mPTP) by binding to ANT3 Xin ShenMengjun MaHuiyong Shen Original Article Open access 25 May 2024 Article: 236
Rescuing tri-heteromeric NMDA receptor function: the potential of pregnenolone-sulfate in loss-of-function GRIN2B variants Shai KellnerShai Berlin Original Article Open access 25 May 2024 Article: 235
Proteomic dissection of vanishing white matter pathogenesis Jodie H. K. ManParand ZarekianiMarianna Bugiani Original Article Open access 24 May 2024 Article: 234
Circulating tumour cells predict recurrences and survival in head and neck squamous cell carcinoma patients Xi ZhangChameera Ekanayake WeeramangeChamindie Punyadeera Original Article Open access 23 May 2024 Article: 233
Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson’s disease Liuyan DingLin LuPingyi Xu Original Article Open access 23 May 2024 Article: 232
CD200R activation on naïve T cells by B cells induces suppressive activity of T cells via IL-24 Kuan-Hua ChuBor-Luen Chiang Original Article Open access 23 May 2024 Article: 231
The evolutionary novelty of insect defensins: from bacterial killing to toxin neutralization Bin GaoShunyi Zhu Original Article Open access 23 May 2024 Article: 230
Dynamic changes in RNA m6A and 5 hmC influence gene expression programs during macrophage differentiation and polarisation Natalia PinelloRenhua SongJustin J.-L. Wong Original Article Open access 23 May 2024 Article: 229
Cardiac-specific PFKFB3 overexpression prevents diabetic cardiomyopathy via enhancing OPA1 stabilization mediated by K6-linked ubiquitination Jinlan LuoShuiqing HuXizhen Xu Original Article Open access 22 May 2024 Article: 228
Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis Lisa GallwitzFlorian BleibaumPaul Saftig Original Article Open access 22 May 2024 Article: 227
Cholesterol neutralized vemurafenib treatment by promoting melanoma stem-like cells via its metabolite 27-hydroxycholesterol Xiaohong WangFeiliang ZhongBo Li Original Article Open access 22 May 2024 Article: 226
Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions Maxime BernardRomain MenetAyman ElAli Original Article Open access 21 May 2024 Article: 225
Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo Yuqi GuiYohan KimBerta Puig Original Article Open access 20 May 2024 Article: 224
PRKN-linked familial Parkinson’s disease: cellular and molecular mechanisms of disease-linked variants Lene ClausenJustyna OkarmusRasmus Hartmann-Petersen Review Open access 20 May 2024 Article: 223
Genome wide inherited modifications of the tomato epigenome by trans-activated bacterial CG methyltransferase Bapatla Kesava Pavan KumarSébastien BeaubiatNicolas Bouché Original Article Open access 20 May 2024 Article: 222
P62 promotes FSH-induced antral follicle formation by directing degradation of ubiquitinated WT1 Ting ZhaoMeina HeChao Wang Original Article Open access 20 May 2024 Article: 221
Transcriptomic profiling and regulatory pathways of cardiac resident macrophages in aging Guofang XiaSimeng ZhuCongfeng Xu Original Article Open access 20 May 2024 Article: 220
HMGA1 regulates trabectedin sensitivity in advanced soft-tissue sarcoma (STS): A Spanish Group for Research on Sarcomas (GEIS) study David S. MouraJose L. Mondaza-HernandezJavier Martin-Broto Original Article Open access 17 May 2024 Article: 219
Autophagy initiation triggers p150Glued–AP-2β interaction on the lysosomes and facilitates their transport Aleksandra TempesKarolina BoguszJacek Jaworski Original Article Open access 17 May 2024 Article: 218
Membrane-bound chemoreception of bitter bile acids and peptides is mediated by the same subset of bitter taste receptors Silvia SchaeferFlorian ZieglerMaik Behrens Original Article Open access 15 May 2024 Article: 217
Structural basis for the distinct roles of non-conserved Pro116 and conserved Tyr124 of BCH domain of yeast p50RhoGAP Srihari ShankarTi Weng ChewJ. Sivaraman Original Article Open access 13 May 2024 Article: 216
Prenatal treatment with preimplantation factor improves early postnatal neurogenesis and cognitive impairments in a mouse model of Down syndrome Manon MoreauRodolphe DardNathalie Janel Original Article Open access 13 May 2024 Article: 215
Circular RNAs in EMT-driven metastasis regulation: modulation of cancer cell plasticity, tumorigenesis and therapy resistance Milad AshrafizadehJingyuan DaiMinglin Zhu Review Open access 11 May 2024 Article: 214
Deciphering the function of the fifth class of Gα proteins: regulation of ionic homeostasis as unifying hypothesis Asmaa Abu ObaidIvan IvandicSigrun I. Korsching Original Article Open access 10 May 2024 Article: 213
Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility Fei-Chen WangXiao-Na ZhangQi-En Yang Original Article Open access 09 May 2024 Article: 212
USP11 regulates proliferation and apoptosis of human spermatogonial stem cells via HOXC5-mediated canonical WNT/β-catenin signaling pathway Jun GaoZhipeng XuLeye He Original Article Open access 09 May 2024 Article: 211
The IMPDH cytoophidium couples metabolism and fetal development in mice Min PengGerson D. KeppekeLi-Ying Sung Original Article Open access 08 May 2024 Article: 210
Physiological and pathological functions of TMEM106B in neurodegenerative diseases Min ZhuGuoxin ZhangZhentao Zhang Review Open access 06 May 2024 Article: 209
PRDM14 extinction enables the initiation of trophoblast stem cell formation Chunfang XuWeijie ZhaoMeirong Du Original Article Open access 06 May 2024 Article: 208
Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules Lukas ZierkeDaniel JohnAli A. Aghdassi Original Article Open access 06 May 2024 Article: 207
LPS-induced monocarboxylate transporter-1 inhibition facilitates lactate accumulation triggering epithelial-mesenchymal transformation and pulmonary fibrosis Jinhua FengHan ZhongZhengyu He Original Article Open access 06 May 2024 Article: 206
Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl3 model Xueying JinXueling YueXian Wu Cheng Original Article Open access 04 May 2024 Article: 205
SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1 Xinxin JinXulei SunHongzhi Sun Original Article 03 May 2024 Article: 204
Rv2231c, a unique histidinol phosphate aminotransferase from Mycobacterium tuberculosis, supports virulence by inhibiting host-directed defense Sheeba ZarinMohd. ShariqNasreen Zafar Ehtesham Original Article Open access 02 May 2024 Article: 203
Functional implications of NHR-210 enrichment in C. elegans cephalic sheath glia: insights into metabolic and mitochondrial disruptions in Parkinson's disease models Rohil HameedAnam NaseerAamir Nazir Original Article Open access 01 May 2024 Article: 202
Update in genetic and epigenetic causes of hypertension Arya Mani Invited review Open access 30 April 2024 Article: 201
Delineating the heterogeneity of senescence-induced-functional alterations in hepatocytes Pavitra KumarMohsin HassanCornelius Engelmann Original Article Open access 30 April 2024 Article: 200
Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling Irene Bodega-MayorPablo Delgado-WickeElena Fernández-Ruiz Original Article Open access 29 April 2024 Article: 199
Molecular mechanisms and therapeutic strategies for neuromuscular diseases Zambon Alberto AndreaFalzone Yuri MatteoPrevitali Stefano Carlo Review Open access 28 April 2024 Article: 198
Engineered platforms for mimicking cardiac development and drug screening Madison StiefboldHaokang ZhangLeo Q. Wan Review Open access 25 April 2024 Article: 197
Telomerase is essential for cardiac differentiation and sustained metabolism of human cardiomyocytes Shambhabi ChatterjeeMegan Leach-MehrwaldChristian Bär Original Article Open access 24 April 2024 Article: 196
Regulation of Notch signaling by non-muscle myosin II Zipper in Drosophila Dipti VermaAnkita SinghAshim Mukherjee Original Article Open access 24 April 2024 Article: 195
Recent advances in mechanisms ensuring the pairing, synapsis and segregation of XY chromosomes in mice and humans Matteo LampittoMarco Barchi Review Open access 23 April 2024 Article: 194
The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases Angela IuzzolinoFrancesca Romana PellegriniDaniela Trisciuoglio Review Open access 23 April 2024 Article: 193
Involvement of the glymphatic/meningeal lymphatic system in Alzheimer’s disease: insights into proteostasis and future directions Kaoru YamadaTakeshi Iwatsubo Review Open access 23 April 2024 Article: 192
