Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation Eva Y. ChiSampathkumar KrishnanJohn F. Carpenter ReviewPaper Pages: 1325 - 1336
Drug Delivery and Transport to Solid Tumors Seong Hoon JangM. Guillaume WientjesJessie L.-S. Au ReviewPaper Pages: 1337 - 1350
Involvement of Nrf2 and JNK1 in the Activation of Antioxidant Responsive Element (ARE) by Chemopreventive Agent Phenethyl Isothiocyanate (PEITC) Young-Sam KeumEdward D. OwuorA.-N. Tony Kong OriginalPaper Pages: 1351 - 1356
Evaluation of an Immortalized Retinal Endothelial Cell Line as an In Vitro Model for Drug Transport Studies Across the Blood-Retinal Barrier Jie ShenStacy T. CrossDevin F. Welty OriginalPaper Pages: 1357 - 1363
Preliminary Investigation into the Expression of Proton-Coupled Oligopeptide Transporters in Neural Retina and Retinal Pigment Epithelium (RPE): Lack of Functional Activity in RPE Plasma Membranes Scott M. OcheltreeRichard F. KeepDavid E. Smith OriginalPaper Pages: 1364 - 1372
Assessment of Temporal Biochemical and Gene Transcription Changes in Rat Liver Cytochrome P450: Utility of Real-Time Quantitative RT-PCR Federico M. GoodsaidJairam R. PalamandaI. Y. Rosenblum OriginalPaper Pages: 1373 - 1380
Amino Acid Ester Prodrugs of Floxuridine: Synthesis and Effects of Structure, Stereochemistry, and Site of Esterification on the Rate of Hydrolysis Balvinder S. VigPhilip J. LorenziGordon L. Amidon OriginalPaper Pages: 1381 - 1388
Inhibitory Effect of Zinc on PEPT1-Mediated Transport of Glycylsarcosine and β-Lactam Antibiotics in Human Intestinal Cell Line Caco-2 Miyako OkamuraTomohiro TeradaKen-ichi Inui OriginalPaper Pages: 1389 - 1393
Involvement of Multidrug Resistance Associated Protein 1 (Mrp1) in the Efflux Transport of 17β Estradiol-D-17β-Glucuronide (E217βG) Across the Blood-Brain Barrier Daisuke SugiyamaHiroyuki KusuharaYuichi Sugiyama OriginalPaper Pages: 1394 - 1400
QSAR Analysis of the Inhibition of Recombinant CYP 3A4 Activity by Structurally Diverse Compounds Using a Genetic Algorithm-Combined Partial Least Squares Method Suchada WanchanaFumiyoshi YamashitaMitsuru Hashida OriginalPaper Pages: 1401 - 1408
Ocular Pharmacokinetic Modeling Using Corneal Absorption and Desorption Rates from in Vitro Permeation Experiments with Cultured Corneal Epithelial Cells Veli-Pekka RantaMirka LaavolaArto Urtti OriginalPaper Pages: 1409 - 1416
The Effect of Low Concentrations of Molecularly Dispersed Poly(Vinylpyrrolidone) on Indomethacin Crystallization from the Amorphous State Kieran J. CrowleyGeorge Zografi OriginalPaper Pages: 1417 - 1422
Thermal Analysis of Trace Levels of Polymorphic Impurity in Salmeterol Xinafoate Samples Henry H. Y. TongBoris Yu. ShekunovAlbert H. L. Chow OriginalPaper Pages: 1423 - 1429
Direct Observation of the Enthalpy Relaxation and the Recovery Processes of Maltose-Based Amorphous Formulation by Isothermal Microcalorimetry Kohsaku KawakamiYasuo Ida OriginalPaper Pages: 1430 - 1436
Investigations into the Stabilization of Drugs by Sugar Glasses: III. The Influence of Various High-pH Buffers Jonas H. C. ErikssonWouter L. J. HinrichsHenderik W. Frijlink OriginalPaper Pages: 1437 - 1443
PEGylated Adenoviruses for Gene Delivery to the Intestinal Epithelium by the Oral Route Xuan ChengXin MingMaria A. Croyle OriginalPaper Pages: 1444 - 1451
Analysis of Hepatic Disposition of Galactosylated Cationic Liposome/Plasmid DNA Complexes in Perfused Rat Liver Shintaro FumotoFumi NakadoriMitsuru Hashida OriginalPaper Pages: 1452 - 1459
Intestinal Lymphatic Transport of Halofantrine Occurs After Oral Administration of a Unit-Dose Lipid-Based Formulation to Fasted Dogs Shui-Mei KhooDavid M. ShacklefordWilliam N. Charman OriginalPaper Pages: 1460 - 1465
Novel Gastroretentive Dosage Forms: Evaluation of Gastroretentivity and Its Effect on Levodopa Absorption in Humans Eytan A. KlausnerEran LavyAmnon Hoffman OriginalPaper Pages: 1466 - 1473
The Effect of Blood Sampling Site and Physicochemical Characteristics of Drugs on Bioavailability After Nasal Administration in the Sheep Model L. IllumM. HinchcliffeS. S. Davis OriginalPaper Pages: 1474 - 1484
Evaluation of An Aerosolized Selective COX-2 Inhibitor as a Potentiator of Doxorubicin in a Non-Small-Cell Lung Cancer Cell Line Alfred HaynesMadhu Sudhan ShaikM. Singh OriginalPaper Pages: 1485 - 1495
Iontophoretic in Vivo Transdermal Delivery of β-Blockers in Hairless Rats and Reduced Skin Irritation by Liposomal Formulation Rajkumar ConjeevaramAyyappa ChaturvedulaAjay K. Banga OriginalPaper Pages: 1496 - 1501
Effect of Vehicle Pretreatment on the Flux, Retention, and Diffusion of Topically Applied Penetrants in Vitro Catarina RosadoSheree E. CrossJonathan Hadgraft OriginalPaper Pages: 1502 - 1507
Transdermal Reverse Iontophoresis of Valproate: A Noninvasive Method for Therapeutic Drug Monitoring M. Begoña Delgado-CharroRichard H. Guy OriginalPaper Pages: 1508 - 1513