1. A search for sources of drug resistance by the 4D-QSAR analysis of a set of antimalarial dihydrofolate reductase inhibitors

   • Osvaldo Andrade Santos-Filho
   • Anton J. Hopfinger

   OriginalPaper Pages: 1 - 12

2. Screening the molecular surface of human anticoagulant protein C: A search for interaction sites

   • Bruno O. Villoutreix
   • David G. Covell
   • Björn Dahlbäck

   OriginalPaper Pages: 13 - 27

3. CoMFA-based comparison of two models of binding site on adenosine A1 receptor

   • Irini Doytchinova

   OriginalPaper Pages: 29 - 39

4. Comparative molecular field analysis (CoMFA) study of epothilones – tubulin depolymerization inhibitors: Pharmacophore development using 3D QSAR methods

   • Keun Woo Lee
   • James M. Briggs

   OriginalPaper Pages: 41 - 55

5. FILO (Field Interaction Ligand Optimization): A simplex strategy for searching the optimal ligand interaction field in drug design

   • Fabrizio Melani
   • Paola Gratteri
   • Claudia Bonaccini

   OriginalPaper Pages: 57 - 66

6. Structure-toxicity relationships of polycyclic aromatic hydrocarbons using molecular quantum similarity

   • Ana Gallegos
   • David Robert
   • Ramon Carbó-Dorca

   OriginalPaper Pages: 67 - 80

7. slate: A method for the superposition of flexible ligands

   • J.E.J. Mills
   • I.J.P. de Esch
   • P.M. Dean

   OriginalPaper Pages: 81 - 96