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Polymer Sponge Replication Technology Derived Strontium-Substituted Apatite (Sr-HAP) Porous Scaffolds for Bone Tissue Engineering

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Abstract

In this research, we developed strontium-substituted apatite (Sr-HAP) scaffolds using the polymeric sponge replication method. Tissue engineering is a potential new technology for replacing damaged tissue with biocompatible artificial templates. The scaffolds prepared with an interconnected porous microstructure with pore sizes ranging from 400 to 622 μm were created as engineering constructions. The physicochemical properties of the Sr-HAP scaffolds were characterized by various techniques such as X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM), and Energy dispersion spectroscopy (EDS). Immersion tests in simulated body fluid (SBF) solution was used to assess the surface reactivity of the resulting scaffolds. More critically, MTT assay tests were utilized to investigate the cell viability of porous Sr-HAP scaffold at varying doses of 10–1000 μg/mL for 24 h. The porosity Sr-HAP scaffolds developed in this study are a potential tissue engineering candidate.

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Acknowledgements

This work supported authors are grateful to ICMR-RA No.45/79/2018-Nan/BMS, New Delhi-India for the financial support and for the research Project Support TNSCST/STP-PRG/AR/2018-19/9282 Chennai, Tamil Nadu, India.

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Authors and Affiliations

  1. Department of Nanoscience and Technology, Bharathiar University, Coimbatore, Tamil Nadu, 641046, India

    Ramadas Munusamy, Abimanyu Ravichandran & Ballamurugan M. Anbalagan

  2. Euromed Engineering Faculty, Université Euromed de Fès, BP 51, Fès principale, Fès, Morocco

    Khalil El Mabrouk

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  1. Ramadas Munusamy
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  2. Abimanyu Ravichandran
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  3. Khalil El Mabrouk
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  4. Ballamurugan M. Anbalagan
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Correspondence to Ballamurugan M. Anbalagan.

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Munusamy, R., Ravichandran, A., El Mabrouk, K. et al. Polymer Sponge Replication Technology Derived Strontium-Substituted Apatite (Sr-HAP) Porous Scaffolds for Bone Tissue Engineering. Biomedical Materials & Devices 1, 504–511 (2023). https://doi.org/10.1007/s44174-022-00017-0

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