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Application of Technetium 99 Metastable Radioactive Nanosystems: Nanoparticles, Liposomes, and Nanoemulsion for Biomedical Application

  • Nanodrugs (ATY Lau, Section Editor)
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Abstract

The uses of nanomedicines, as polymeric nanoparticles, nanoemulsion, or liposomes, are increasingly in vogue in the last few years. These nanosystems have several biomedical applications, and their potentiality overpass the regular drug-based system. Recently, most of these nanosystems have been used as theranostic agent, by grafting radioactive materials especially 99mTc, which has imaging properties. Herein, it is provided a milestone in this research field, revising the production and application of radioactive nanosystems coupled to the 99mTc for both diagnosis and therapy. The mechanisms of action and nanosystem action were made explicit in order to make this review a constant source of consultation. From the collected data, it is clear the need of rapid translation for human use, real gain and social relevance, since most of the radioactive nanosystems have been used for tumor early diagnosis and/or therapy. Overall, the use of nanosystem coupled with 99mTc is increasing and the future of modern medicine, especially the nuclear medicine, relies on the correct use of these nanosystems and on the development of new ones.

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  1. Laboratory of Radiopharmacy and Nanoradiopharmaceuticals, Zona Oeste State University, Rio de Janeiro, Brazil

    Ralph Santos-Oliveira

  2. Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rio de Janeiro, Brazil

    Ralph Santos-Oliveira

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Santos-Oliveira, R. Application of Technetium 99 Metastable Radioactive Nanosystems: Nanoparticles, Liposomes, and Nanoemulsion for Biomedical Application. Curr Pharmacol Rep 5, 281–302 (2019). https://doi.org/10.1007/s40495-019-00190-9

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