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Genetic and Non-Genetic Determinants of Circulating Levels of Adiponectin in a Cohort of Chilean Subjects

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Abstract

Background

Low adiponectin levels have been associated with obesity, diabetes, coronary disease and polymorphisms. The aim of this study was to assess the clinical and genetic factors related to adiponectin levels in a Chilean adult population.

Methods

Four groups of 27 individuals, stratified by gender and abdominal obesity, were included in this cross-sectional study. Physical activity level, cardiovascular risk factors and therapy were assessed. Anthropometric measurements, adiponectin, glucose, insulin, hs-CRP, rs1501299, rs2241766, rs266729 and rs17300539 single nucleotide polymorphisms of the adiponectin gene were determined.

Results

Adiponectin levels were inversely correlated with waist circumference, waist-to-hip ratio, weight, body mass index, insulin levels, homeostasis model insulin resistance index (HOMA-IR) and physical activity. Mean adiponectin levels were lower in men (10.1 ± 3.6 vs 11.9 ± 2.9 μg/mL, p = 0.0051), obese (9.9 ± 3.2 vs 12.1 ± 3.3, p < 0.01), physically inactive (8.9 ± 3.2 vs 11.0 ± 2.8, p = 0.015) and insulin-resistant individuals (10.2 ± 3.1 vs 12.9 ± 3.9; p = 0.005). Adiponectin levels were lower in subjects with GG genotype (rs1501299) compared with those with TT or GT variants (6.9 ± 4.6 vs 12.2 ± 2.9 and 11.5 ± 3.4 μg/mL, p = 0.006) but were similar in the other polymorphisms studied.

Conclusion

Lower adiponectin levels were related to gender, abdominal obesity, physical activity and insulin resistance and were less influenced by the polymorphisms studied.

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Acknowledgments

This study was supported by Dirección de Investigación y Desarrollo, Universidad de La Frontera (DIDUFRO DI13-0012). J. R. is the recipient of fellowship from CONICYT, Chile. N. S. is the recipient of a post-doctoral fellowship from Convenio de Desempeño—Universidad de La Frontera.

Author contributions

FL, PS and LAS conceived and designed the experiment; NS, JR and LAS performed the experiments; FL, PS, NS and LAS analysed the data; LAS and FL contributed reagents/materials/analysis tools; FL and LAS wrote the paper.

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Authors and Affiliations

  1. Department of Internal Medicine, Universidad de La Frontera, Temuco, Chile

    Fernando Lanas & Pamela Serón

  2. Universitat Autònoma de Barcelona, Barcelona, Spain

    Fernando Lanas

  3. Departamento de Ciencias Básicas, Facultad de Medicina, Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco, Chile

    Fernando Lanas, Nicolás Saavedra, Jenny Ruedlinger & Luis Salazar

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  1. Fernando Lanas
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  2. Pamela Serón
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Correspondence to Fernando Lanas or Luis Salazar.

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None of the authors has a relationship with a for-profit company or institution. No competing financial interests exist.

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Lanas, F., Serón, P., Saavedra, N. et al. Genetic and Non-Genetic Determinants of Circulating Levels of Adiponectin in a Cohort of Chilean Subjects. Mol Diagn Ther 19, 197–204 (2015). https://doi.org/10.1007/s40291-015-0146-3

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