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Injectable Biomaterials in Plastic and Reconstructive Surgery: A Review of the Current Status

  • Review Article
  • Published:
Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

Background:

Injectable biomaterials have attracted increasing attention for volume restoration and tissue regeneration. The main aim of this review is to discuss the current status of the injectable biomaterials for correction of tissue defects in plastic and reconstructive surgery.

Methods:

Requirements of injectable biomaterials, mechanism of in situ gelation, characteristics, and the combinational usage of adipose-derived stem cells (ADSCs) and growth factors were reviewed.

Results:

The ideal injectable biomaterials should be biocompatible, non-toxic, easy to use, and cost-effective. Additionally, it should possess adequate mechanical properties and stability. In situ gelation method includes physical, chemical, enzymatic and photo-initiated methods. Natural and synthetic biomaterials carry their pros and cons due to their inherent properties. The combined use of ADSCs and growth factors provides enhanced potential for adipose tissue regeneration.

Conclusions:

The usage of injectable biomaterials has been increasing for the tissue restoration and regeneration. The future of incorporating ADSCs and growth factors into the injectable biomaterials is promising.

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Fig. 1

Modified from Ref. [9]

Fig. 2

Reproduced with permission [113] of John Wiley and Sons, Inc.

Fig. 3

Reproduced with permission [117] of John Wiley and Sons, Inc.

Fig. 4

Reproduced with permission [118] of John Wiley and Sons, Inc

Fig. 5

Reproduced with permission [121] Copyright © 2018, Elsevier

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Acknowledgements

This work was supported by the by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2016936920).

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Authors and Affiliations

  1. Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, 44195, USA

    Ki-Hyun Cho

  2. Department of Polymer Science and Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, Republic of Korea

    Saji Uthaman

  3. Department of Biomedical Sciences, Chonnam National University Medical School, 160 Baekseo-ro, Gwangju, 61469, Republic of Korea

    In-Kyu Park

  4. Research Institute for Agriculture and Life Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea

    Chong-Su Cho

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  1. Ki-Hyun Cho
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  2. Saji Uthaman
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Correspondence to Chong-Su Cho.

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Cho, KH., Uthaman, S., Park, IK. et al. Injectable Biomaterials in Plastic and Reconstructive Surgery: A Review of the Current Status. Tissue Eng Regen Med 15, 559–574 (2018). https://doi.org/10.1007/s13770-018-0158-2

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  • DOI: https://doi.org/10.1007/s13770-018-0158-2

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