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Fabrication and characterization of hydrocolloid dressing with silk fibroin nanoparticles for wound healing

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Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

Hydrocolloid dressings have been developed for many types of wound healing. In particular, dressing is a critical component in the successful recover of burn injuries, which causes a great number of people to not only suffer from physical but also psychological and economic anguish each year. Additionally, silk fibroin is the safest material for tissue engineering due to biocompatibility. In this study, we fabricated hydrocolloid dressings incorporating silk fibroin nanoparticles to enhance the efficacy of hydrocolloid dressing and then use this silk fibroin nanoparticle hydrocolloid dressing (SFNHD) in animal models to treat burn wounds. The structures and properties of SFNHD were characterized using tensile strength and Cell Counting Kit-8 assay. The results indicated the structural stability and the cellular biocompatibility of the hydrocolloid dressing suggesting that SFNHD can be applied to the treatment of wounds. To demonstrate the capacity of a silk fibroin hydrocolloid dressing to treat burn wounds, we compared SFNHD to gauze and Neoderm®, a commercially available dressing. This study clearly demonstrated accelerated wound healing with greater wound structural integrity and minimal wound size after treatment with SFNHD. These observations indicate that SFNHD may be an improvement upon current standard dressings such as Gauze and Neoderm® for burn wounds.

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Authors and Affiliations

  1. Nano-Bio Regenerative Medical Institute, Hallym University, 1 Hallymdaehak-gil, Chuncheon, 24252, Korea

    Ok Joo Lee, Jung-Ho Kim, Bo Mi Moon, Hyung Woo Ju, Jung Min Lee, Hyun Jung Park, Dong Wook Kim & Chan Hum Park

  2. School of Medicine, George Washington University, Washington, D.C., USA

    Janet Ren Chao

  3. Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick, Frederick, MD, USA

    Jaeho Yoon

  4. Department of Anesthesiology, Chuncheon Sacred Heart Hospital, School of Medicine, Hallym University, Chuncheon, Korea

    Seung Ju Kim

  5. Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, School of Medicine, Hallym University, 77 Sakju-ro, Chuncheon, 24253, Korea

    Hae Sang Park & Chan Hum Park

Authors
  1. Ok Joo Lee
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  2. Jung-Ho Kim
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  3. Bo Mi Moon
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  4. Janet Ren Chao
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  5. Jaeho Yoon
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  6. Hyung Woo Ju
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  7. Jung Min Lee
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  8. Hyun Jung Park
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  9. Dong Wook Kim
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  10. Seung Ju Kim
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  11. Hae Sang Park
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  12. Chan Hum Park
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Corresponding author

Correspondence to Chan Hum Park.

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These authors contributed equally to this work.

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Lee, O.J., Kim, JH., Moon, B.M. et al. Fabrication and characterization of hydrocolloid dressing with silk fibroin nanoparticles for wound healing. Tissue Eng Regen Med 13, 218–226 (2016). https://doi.org/10.1007/s13770-016-9058-5

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  • DOI: https://doi.org/10.1007/s13770-016-9058-5

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