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Electrospun polyvinylidene pyrolidone/gelatin membrane impregnated with silver sulfadiazine as wound dressing for burn treatment

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Abstract

Nanofibrous membranes used for burn treatment have become widely popular due to their large surface area and high porous structure. In this study, electrospinning was used to fabricate a blended nanofibrous membrane of polyvinylidene pyrolidone (PVP) and gelatin, to use as wound dressing. The physical and mechanical properties of this novel membrane were investigated using SEM, FTIR and tensile tests. Results showed that poor mechanical properties of gelatin, which are preferred in medical applications for curing burns as they allow for antigen activity and skin repair, can be enhanced by adding PVP in the solution. Silver sulfadiazine (AgSD), an antibacterial agent, was also impregnated into the PVP/gelatin nanofibrous structure during electrospinning. The membrane thus fabricated showed antibacterial activities against both the Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. AgSD release behaviour of fabricated samples indicated short-term drug delivery. It was concluded that the proposed drug-loaded membrane can be used as wound dressing, specifically, in treating skin burns.

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Acknowledgements

We would like to acknowledge Emad Darman Drug Company for providing silver sufadiazine during the research, which is free of charge. Also, we pay special thanks to Research Institute for Biotechnology and Bioengineering of Isfahan University of Technology for antimicrobial tests.

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Authors and Affiliations

  1. Department of Textile Engineering, Isfahan University of Technology, Isfahan, 845156-83111, Iran

    Dariush Semnani, Nazanin Poursharifi, Nooshin Banitaba & Aref Fakhrali

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  1. Dariush Semnani
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  2. Nazanin Poursharifi
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  3. Nooshin Banitaba
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  4. Aref Fakhrali
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Correspondence to Dariush Semnani.

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Semnani, D., Poursharifi, N., Banitaba, N. et al. Electrospun polyvinylidene pyrolidone/gelatin membrane impregnated with silver sulfadiazine as wound dressing for burn treatment. Bull Mater Sci 41, 72 (2018). https://doi.org/10.1007/s12034-018-1601-7

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  • DOI: https://doi.org/10.1007/s12034-018-1601-7

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