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Rat defect models for bone grafts and tissue engineered bone constructs

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Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

The development of optimized biomaterials for restoring bone defects has been ongoing for many years. Animal models for testing bone grafts and tissue engineered constructs are an important aspect of this research. New bone scaffolding systems need to be tested both in vitro and in vivo, but ultimately animal studies provide answers and confidence in their efficacy prior to clinical applications. A robust set of rat models for understanding bone development in response to implanted materials have been developed. This review will describe frequently used rat bone defect models, such as the calvarial defect, long bone defect, and maxillofacial bone defect models.

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Authors and Affiliations

  1. Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Yongin-si, Republic of Korea

    Joong-Hyun Kim & Hae-Won Kim

  2. Department of Nanobiomedical Science and WCU Research Center, Dankook University, Yongin-si, Republic of Korea

    Joong-Hyun Kim & Hae-Won Kim

  3. Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, 330-714, South Korea

    Hae-Won Kim

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  1. Joong-Hyun Kim
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Correspondence to Hae-Won Kim.

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Kim, JH., Kim, HW. Rat defect models for bone grafts and tissue engineered bone constructs. Tissue Eng Regen Med 10, 310–316 (2013). https://doi.org/10.1007/s13770-013-1093-x

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