Abstract
Quercetin and kaempferol, two well-known flavonols, were chemically conjugated with glucose to produce the corresponding flavonol glucosides, and the following biological activities were evaluated for cosmeceutical development: antioxidant activity, ability to increase collagen synthesis, and moisturizing activity. Among the synthetic flavonol glucosides, quercetin-3-O-β-D-glucoside significantly enhanced collagen synthesis (60 %) compared to quercetin. Kaempferol-3,7-di-O-β-D-glucoside showed promising skin-moisturizing effects, inducing a sixfold increase in the expression of aquaporin-3. Thus, both quercetin-3-O-β-D-glucoside and kaempferol-3,7-di-O-β-D-glucoside were shown to possess interesting biological activities which warrant their further development as cosmetic ingredients.
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This research was supported by Konkuk University in 2014.
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Kwang-Su Park, Hyungmi Kim, have contributed equally to this work.
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Park, KS., Kim, H., Kim, M.K. et al. Synthesis and biological evaluation of flavonol-glucose conjugates for cosmeceutical development. J Korean Soc Appl Biol Chem 58, 317–323 (2015). https://doi.org/10.1007/s13765-015-0049-3
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DOI: https://doi.org/10.1007/s13765-015-0049-3