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QSPR/QSAR solely based on molecular surface electrostatic potentials for benzenoid hydrocarbons

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Abstract

Benzenoid hydrocarbons are a group of the most important π-electron systems having the attention of both experimental and theoretical chemists for the last 100 years. In the present study, based on the general interaction properties function (GIPF) family descriptors, significant one- or two-parametric quantitative structure–property (activity) relationship models were developed for the prediction of properties/activities of benzenoids hydrocarbons. All descriptors were computed in density functional theory (DFT) at the B3LYP/STO-3G level of theory in Gaussian98 software. A large number of physico-chemical properties and two biological activities (e.g. bio-concentration factor and photo-induced toxicity) of these compounds were investigated by using multiple linear regressions. All created models were interpreted in term of selected descriptors. R 2 and R 2cv values of all models are respectively between 0.665–0.994 and 0.609–0.990 for the whole dataset of each property/activity. Maximum R 2 for Y-randomization (R 2max ) test and its cross-validation (R 2cv ,max) are between 0.098–0.485 and 0.002–0.357, respectively.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Kurdistan, P. O. Box 416, Sanandaj, Iran

    Raouf Ghavami & Bakhtyar Sepehri

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  1. Raouf Ghavami
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  2. Bakhtyar Sepehri
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Correspondence to Raouf Ghavami.

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Ghavami, R., Sepehri, B. QSPR/QSAR solely based on molecular surface electrostatic potentials for benzenoid hydrocarbons. J IRAN CHEM SOC 13, 519–529 (2016). https://doi.org/10.1007/s13738-015-0761-2

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