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Acute respiratory infection and pneumonia in India: A systematic review of literature for advocacy and action: UNICEF-PHFI series on newborn and child health, India

  • Reviews on Child Health Priorities
  • Published:
Indian Pediatrics Aims and scope Submit manuscript

Abstract

Background

Scaling up of evidence-based management of childhood acute respiratory infection/pneumonia, is a public health priority in India, and necessitates robust literature review, for advocacy and action.

Objective

To identify, synthesize and summarize current evidence to guide scaling up of management of childhood acute respiratory infection/pneumonia in India, and identify existing knowledge gaps.

Methods

A set of ten questions pertaining to the management (prevention, treatment, and control) of childhood ARI/ pneumonia was identified through a consultative process. A modified systematic review process developed a priori was used to identify, synthesize and summarize, research evidence and operational information, pertaining to the problem in India. Areas with limited or no evidence were identified as knowledge gaps.

Results

Childhood ARI/pneumonia is a significant public health problem in India, although robust epidemiological data is not available on its incidence. Mortality due to pneumonia accounts for approximately one-fourth of the total deaths in under five children, in India. Pneumonia affects children irrespective of socioeconomic status; with higher risk among young infants, malnourished children, non-exclusively breastfed children and those with exposure to solid fuel use. There is lack of robust nation-wide data on etiology; bacteria (including Pneumococcus, H. influenzae, S. aureus and Gram negative bacilli), viruses (especially RSV) and Mycoplasma, are the common organisms identified. In-vitro resistance to cotrimoxazole is high. Wheezing is commonly associated with ARI/pneumonia in children, but difficult to appreciate without auscultation. The current WHO guidelines as modified by IndiaCLEN Task force on Penumonia (2010), are sufficient for case-management of childhood pneumonia. Other important interventions to prevent mortality are oxygen therapy for those with severe or very severe pneumonia and measles vaccination for all infants. There is insufficient evidence for protective or curative effect of vitamin A; zinc supplementation could be beneficial to prevent pneumonia, although it has no therapeutic benefit. There is insufficient evidence on potential effectiveness and cost-effectiveness of Hib and Pneumococcal vaccines on reduction of ARI specific mortality. Case-finding and community-based management are effective management strategies, but have low coverage in India due to policy and programmatic barriers. There is a significant gap in the utilization of existing services, provider practices as well as family practices in seeking care.

Conclusion

The systematic review summarizes current evidence on childhood ARI and pneumonia management and provides evidence to inform child health programs in India

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References

  1. Mathew JL, Shah D, Gera T, Gogia S, Mohan P, Panda R, et al. UNICEF-PHFI Newborn and Child Health Series — India. Systematic Reviews on Child Health Priorities for Advocacy and Action: Methodology. Indian Pediatr. 2011;48:183–189.

    Article  PubMed  Google Scholar 

  2. International Institute for Population Sciences (IIPS). National Family Health Survey (MCH and Family Planning), 1992–93: India. Mumbai: IIPS; 1995.

  3. International Institute for Population Sciences (IIPS) and ORC Macro. National Family Health Survey (NFHS-2), 1998–99: India. Mumbai: IIPS; 2000.

    Google Scholar 

  4. International Institute for Population Sciences (IIPS) and Macro International. National Family Health Survey (NFHS-3), 2005–06: India. Mumbai: IIPS; 2008.

    Google Scholar 

  5. http://cbhidghs.nic.in/writereaddata/linkimages/8%20Health%20Status%20Indicators4950277739.pdf. Accessed on 22 May 2010.

  6. Rudan I, Boschi-Pinto C, Biloglav Z, Mulholand K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bull WHO. 2008;86:408–416.

    PubMed  Google Scholar 

  7. Pneumonia: the forgotten killer of children. Geneva: The United Nations Children’s Fund (UNICEF)/World Health Organization (WHO); 2006.

  8. Mathew JL. Pneumococcal vaccination in developing countries: Where does science end and commerce begin? Vaccine. 2009;27:4247–4251.

    Article  PubMed  Google Scholar 

  9. Acharya D, Prasanna KS, Nair S, Rao RS. Acute respiratory infections in children: a community based longitudinal study in south India. Indian J Public Health. 2003;47:7–13.

    PubMed  CAS  Google Scholar 

  10. Deb SK. Acute respiratory disease survey in Tripura in case of children below five years of age. J Indian Med Assoc. 1998;96:111–116.

    PubMed  CAS  Google Scholar 

  11. Awasthi S, Pande VK. Seasonal pattern of morbidities in preschool slum children in Lucknow, north India. Indian Pediatr 1997;34:987–993.

    PubMed  CAS  Google Scholar 

  12. Reddaiah VP, Kapoor SK. Epidemiology of pneumonia in rural underfives. Indian J Pediatr. 1990;57:701–704.

    Article  PubMed  CAS  Google Scholar 

  13. Gupta M, Kumar R, Deb AK, Bhattacharya SK, Bose A, John J, et al. Multi-center surveillance for pneumonia & meningitis among children (<2 yr) for Hib vaccine probe trial preparation in India. Indian J Med Res. 2010;131:649–665.

    PubMed  Google Scholar 

  14. Registrar General of India. Report on causes of death in India 2001–2003. Sample registration system. New Delhi: RGI, Ministry of Home Affairs; 2009.p.19–27.

    Google Scholar 

  15. The Million Death Study Collaborators. Causes of neonatal and child mortality in India: a nationally representative mortality survey. Published online November 13, 2010 DOI:10.1016/S0140-6736(10)61461-4. Available at www.thelancet.com.

  16. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet. 2010 May 11. [Epub ahead of print]

  17. Lahariya C, Sudfeld CR, Lahariya D, Tomar SS. Causes of child deaths in India, 1985–2008: a systematic review of literature. Indian J Pediatr. 2010; 77: 1303–1311

    Article  PubMed  Google Scholar 

  18. Lahariya C, Paul VK. Burden, differentials, and causes of child deaths in India. Indian J Pediatr. 2010; 77: 1312–1321.

    Article  PubMed  Google Scholar 

  19. Tiewsoh K, Lodha R, Pandey RM, Broor S, Kalaivani M, Kabra SK. Factors determining the outcome of children hospitalized with severe pneumonia. BMC Pediatr. 2009;9:15–19.

    Article  PubMed  Google Scholar 

  20. Asghar R, Banajeh S, Egas J, Hibberd P, Iqbal I, Katep-Bwalya M, et al. Chloramphenicol versus ampicillin plus gentamicin for community acquired very severe pneumonia among children aged 2–59 months in low resource settings: multicentre randomised controlled trial (SPEAR study). BMJ. 2008;336:80–84.

    Article  PubMed  CAS  Google Scholar 

  21. Sehgal V, Sethi GR, Sachdev HP, Satyanarayana L. Predictors of mortality in subjects hospitalized with acute lower respiratory tract infections. Indian Pediatr. 1997;34:213–219.

    PubMed  CAS  Google Scholar 

  22. Awasthi S, Pande VK, Glick H. Under fives mortality in the urban slums of Lucknow. Indian J Pediatr. 1996;63:363–368.

    Article  PubMed  CAS  Google Scholar 

  23. Awasthi S, Pande VK. Cause-specific mortality in under fives in the urban slums of Lucknow, north India. J Trop Pediatr. 1998; 44:358–361.

    Article  PubMed  CAS  Google Scholar 

  24. Mahalanabis D, Gupta S, Paul D, Gupta A, Lahiri M, Khaled MA. Risk factors for pneumonia in infants and young children and the role of solid fuel for cooking: a case-control study. Epidemiol Infect. 2002;129:65–71.

    Article  PubMed  CAS  Google Scholar 

  25. Bassani DG, Jha P, Dhingra N, Kumar R. Child mortality from solid-fuel use in India: a nationally-representative case-control study. BMC Public Health. 2010;10:491–499.

    PubMed  Google Scholar 

  26. Chisti MJ, Tebruegge M, La Vincente S, Graham SM, Duke T. Pneumonia in severely malnourished children in developing countries — mortality risk, aetiology and validity of WHO clinical signs: a systematic review. Trop Med Int Health. 2009;14:1173–1789.

    Article  PubMed  Google Scholar 

  27. Deivanayagam N, Nedunchelian K, Ramasamy S, Sudhandirakannan, Ratnam SR. Risk factors for fatal pneumonia: a case control study. Indian Pediatr. 1992; 29:1529–1532.

    PubMed  CAS  Google Scholar 

  28. Kabra SK, Lodha R, Broor S, Chaudhary R, Ghosh M, Maitreyi RS. Etiology of acute lower respiratory tract infection. Indian J Pediatr. 2003;70:33–36.

    Article  PubMed  CAS  Google Scholar 

  29. Patwari AK, Bisht S, Srinivasan A, Deb M, Chattopadhya D. Aetiology of pneumonia in hospitalized children. J Trop Pediatr. 1996;42:15–20.

    Article  PubMed  CAS  Google Scholar 

  30. ISCAP Group Study, Awasthi S. Three-day versus five-day treatment with amoxicillin for non-severe pneumonia in young children: a multicentre randomised controlled trial. BMJ. 2004;328:791–795.

    Article  PubMed  CAS  Google Scholar 

  31. Kanungo R, Rajalakshmi B. Serotype distribution & antimicrobial resistance in Streptococcus pneumoniae causing invasive & other infections in south India. Indian J Med Res. 2001;114:127–132.

    PubMed  CAS  Google Scholar 

  32. John TJ, Pai R, Lalitha MK, Jesudason MV, Brahmadathan KN, Sridharan G, Steinhoff MC. Indian J Med Res.1996;104:205–207.

    PubMed  CAS  Google Scholar 

  33. Invasive Bacterial Infections Surveillance (IBIS) Group, International Clinical Epidemiology Network (INCLEN). Prospective multicentre hospital surveillance of Streptococcus pneumoniae disease in India. Lancet. 1999;353:1216–1221.

    Article  Google Scholar 

  34. Steinhoff MC, Thomas K, Lalitha MK, for the Invasive Bacterial Infections Surveillance Group of the International Clinical Epidemiology Network. Are Haemophilus influenzae infections a significant problem in India? A prospective study and review. Clin Infect Dis. 2002;34:949–957.

    Article  Google Scholar 

  35. Singhi SC, Mohankumar D, Singhi PD, Sapru S, Ganguly NK. Evaluation of polymerase chain reaction (PCR) for diagnosing Haemophilus influenzae b meningitis. Ann Trop Paediatr. 2002;22:347–353.

    Article  PubMed  Google Scholar 

  36. Chaudhry R, Nazima N, Dhawan B, Kabra SK. Prevalence of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community acquired pneumonia. Indian J Pediatr. 1998;65:717–721.

    Article  PubMed  CAS  Google Scholar 

  37. Hemalatha R, Swetha GK, Seshacharyulu M, Radhakrishna KV. Respiratory syncitial virus in children with acute respiratory infections. Indian J Pediatr.2010;77:755–758.

    CAS  Google Scholar 

  38. Jain A, Pande A, Misra PK, Mathur A, Chaturvedi UC. An Indian hospital study of viral causes of acute respiratory infection in children. J Med Microbiol 1991;35:219–223.

    Article  PubMed  CAS  Google Scholar 

  39. Coles CL, Rahmathullah L, Kanungo R, Thulasiraj RD, Katz J, Santosham M, Tielsch JM. Nasopharyngeal carriage of resistant pneumococci in young South Indian infants. Epidemiol Infect. 2002;129:491–497.

    Article  PubMed  CAS  Google Scholar 

  40. Jebaraj R, Cherian T, Raghupathy P, Brahmadathan KN, Lalitha MK, Thomas K, Steinhoff MC. Nasopharyngeal colonization of infants in southern India with Streptococcus pneumoniae. Epidemiol Infect. 1999; 123:383–388.

    Article  PubMed  CAS  Google Scholar 

  41. Nag VL, Ayyagari A, Venkatesh V, Ghar M, Yadav V, Prasad KN. Drug resistant Haemophilus influenzae from respiratory tract infection in a tertiary care hospital in north India. Indian J Chest Dis Allied Sci. 2001;43:13–17.

    PubMed  CAS  Google Scholar 

  42. Agarwal V, Jain D, Pathak AA, Saoji AM. Characterisation of invasive Haemophilus influenzae isolated in Nagpur, central India. Indian J Med Res. 1996;103:296–298.

    PubMed  CAS  Google Scholar 

  43. Jain A, Kumar P, Awasthi S. High ampicillin resistance in different biotypes and serotypes of Haemophilus influenzae colonizing the nasopharynx of healthy schoolgoing Indian children. J Med Microbiol. 2006;55:133–137.

    Article  PubMed  CAS  Google Scholar 

  44. Goyal A, Prasad KN, Prasad A, Gupta S, Ghoshal U, Ayyagari A. Extended spectrum beta-lactamases in Escherichia coli & Klebsiella pneumoniae & associated risk factors. Indian J Med Res. 2009;129:695–700.

    PubMed  CAS  Google Scholar 

  45. Jain A, Mondal R. Detection of extended spectrum betalactamase production in clinical isolates of Klebsiella spp. Indian J Med Res. 2008;127:344–346.

    PubMed  Google Scholar 

  46. Kumar S, Rizvi M, Vidhani S, Sharma VK. Changing face of septicaemia and increasing drug resistance in blood isolates. Indian J Pathol Microbiol. 2004;47:441–446.

    PubMed  Google Scholar 

  47. Kabra SK, Lodha R, Pandey RM. Antibiotics for community-acquired pneumonia in children. Cochrane Database Syst Rev. 2010;3:CD004874.

    PubMed  Google Scholar 

  48. Kabra SK, Lodha R, Pandey RM. Antibiotics for community acquired pneumonia in children. Cochrane Database Syst Rev. 2006; 3:CD004874.

    PubMed  CAS  Google Scholar 

  49. Awasthi S, Agarwal G, Singh JV, Kabra SK, Pillai RM, Singhi S, et al., for ICMR IndiaClen Pneumonia Project Group. Effectiveness of 3-day Amoxicillin vs. 5-day cotrimoxazole in the treatment of non-severe pneumonia in children aged 2–59 months of age: a multi-centric open labeled trial. J Trop Pediatr. 2008;54:382–389.

    Article  PubMed  Google Scholar 

  50. Addo-Yobo E, Chisaka N, Hassan M, Hibberd P, Lozano JM, Jeena P, et al. Oral amoxicillin versus injectable penicillin for severe pneumonia in children aged 3 to 59 months: a randomised multicentre equivalency study. Lancet. 2004;364:1141–8.2--

    Article  PubMed  CAS  Google Scholar 

  51. Cetinkaya F, Gogremis A, Kutluk G. Comparison of two antibiotic regimens in the empirical treatment of severe childhood pneumonia. Indian J Pediatr. 2004;71:969–972.

    Article  PubMed  Google Scholar 

  52. WHO. http://whqlibdoc.who.int/hq/2004/WHO_FCH_CAH_04.2.pdf. Accessed February 15, 2011.

  53. Mulholland S, Gavranich JB, Chang AB. Antibiotics for community-acquired lower respiratory tract infections secondary to Mycoplasma pneumoniae in children. Cochrane Database Syst Rev. 2010;7:CD004875.

    PubMed  Google Scholar 

  54. Dekate PS, Mathew JL, Jayashree M, Singhi S. Acute community acquired pneumonia in emergency room. in press.

  55. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community acquired pneumonia in adults. Clin Infect Dis. 2007;44Suppl 2:S27–S72.

    Article  PubMed  CAS  Google Scholar 

  56. Ashraf H, Mahmud R, Alam NH, Jahan SA, Kamal SM, Haque F, et al. Randomized controlled trial of day care versus hospital care of severe pneumonia in Bangladesh. Pediatrics. 2010;126:e807–e815.

    Article  PubMed  Google Scholar 

  57. Rojas MX, Granados C. Oral antibiotics versus parenteral antibiotics for severe pneumonia in children. Cochrane Database Syst Rev. 2006;2:CD004979.

    PubMed  Google Scholar 

  58. Lorgelly PK, Atkinson M, Lakhanpaul M, Smyth AR, Vyas H, Weston V, Stephenson T. Oral versus i.v. antibiotics for community-acquired pneumonia in children: a cost-minimisation analysis. Eur Respir J. 2010;35:858–864.

    Article  PubMed  CAS  Google Scholar 

  59. Hazir T, Qazi SA, Bin Nisar Y, Maqbool S, Asghar R, Iqbal I, et al. Comparison of standard versus double dose of amoxicillin in the treatment of non-severe pneumonia in children aged 2–59 months: a multi-center, double blind, randomised controlled trial in Pakistan. Arch Dis Child 2007;92:291–297.

    Article  PubMed  Google Scholar 

  60. Rasmussen ZA, Bari A, Qazi S, Rehman G, Azam I, Khan SB, et al. Randomized controlled trial of standard versus double dose cotrimoxazole for childhood pneumonia in Pakistan. Bull WHO. 2005;83:10–19.

    PubMed  Google Scholar 

  61. Haider BA, Saeed MA, Bhutta ZA. Short-course versus long-course antibiotic therapy for non-severe communityacquired pneumonia in children aged 2 months to 59 months. Cochrane Database Syst Rev. 2008;2:CD005976.

    PubMed  Google Scholar 

  62. Dimopoulos G, Matthaiou DK, Karageorgopoulos DE, Grammatikos AP, Athanassa Z, Falagas ME. Short-versus long-course antibacterial therapy for community-acquired pneumonia: a meta-analysis. Drugs. 2008;68:1841–1854.

    Article  PubMed  CAS  Google Scholar 

  63. Pakistan Multicentre Amoxicillin Short Course Therapy (MASCOT) pneumonia study group. Clinical efficacy of 3 days versus 5 days of oral amoxicillin for treatment of childhood pneumonia: a multicentre double-blind trial. Lancet. 2002;360:835–841.

    Article  Google Scholar 

  64. Shann F, D’souza RM, D’souza R. Antibiotics for preventing pneumonia in children with measles. Cochrane Database Syst Rev. 2007;3:CD001477.

    PubMed  Google Scholar 

  65. Subhi R, Adamson M, Campbell H, Weber M, Smith K, Duke T; Hypoxemia in Developing Countries Study Group. The prevalence of hypoxemia among ill children in developing countries: a systematic review. Lancet Infect Dis. 2009;9:219–227.

    Article  PubMed  Google Scholar 

  66. Lozano JM. Epidemiology of hypoxemia in children with acute lower respiratory infection. Int J Tuberc Lung Dis. 2001;5:496–504.

    PubMed  CAS  Google Scholar 

  67. Wandi F, Peel D, Duke T. Hypoxemia among children in rural hospitals in Papua New Guinea: epidemiology and resource availability—a study to support a national oxygen program. Ann Trop Paediatr. 2006;26:277–284.

    Article  PubMed  Google Scholar 

  68. Basnet S, Adhikari RK, Gurung CK. Hypoxemia in children with pneumonia and its clinical predictors. Indian J Pediatr. 2006;73:777–781.

    Article  PubMed  Google Scholar 

  69. Mwaniki MK, Nokes DJ, Ignas J, Munywoki P, Ngama M, Newton CR, et al. Emergency triage assessment for hypoxemia in neonates and young children in a Kenyan hospital: an observational study. Bull WHO. 2009;87:263–270.

    PubMed  Google Scholar 

  70. Rojas MX, Granados Rugeles C, Charry-Anzola LP. Oxygen therapy for lower respiratory tract infections in children between 3 months and 15 years of age. Cochrane Database Syst Rev. 2009;1:CD005975.

    PubMed  Google Scholar 

  71. Usen S, Webert M. Clinical signs of hypoxemia in children with acute lower respiratory infection: indicators of oxygen therapy. Int J Tuberc Lung Dis. 2001;5:505–510.

    PubMed  CAS  Google Scholar 

  72. Laman M, Ripa P, Vince J, Tefuarani N. Can clinical signs predict hypoxemia in Papua New Guinean children with moderate and severe pneumonia? Ann Trop Paediatr. 2005;25:23–27.

    Article  PubMed  Google Scholar 

  73. Smyth A, Carty H, Hart CA. Clinical predictors of hypoxemia in children with pneumonia. Ann Trop Paediatr. 1998;18:31–40.

    PubMed  CAS  Google Scholar 

  74. Muhe L, Webert M. Oxygen delivery to children with hypoxemia in small hospitals in developing countries. Int J Tuberc Lung Dis. 2001; 5:527–532.

    PubMed  CAS  Google Scholar 

  75. Duke T, Wandi F, Jonathan M, Matai S, Kaupa M, Saavu M, et al. Improved oxygen systems for childhood pneumonia: a multihospital effectiveness study in Papua New Guinea. Lancet. 2008;372:1328–1333.

    Article  PubMed  Google Scholar 

  76. Enarson P, La Vincente S, Gie R, Maganga E, Chokani C. Implementation of an oxygen concentrator system in district hospital paediatric wards throughout Malawi. Bull WHO. 2008;86:344–348.

    PubMed  Google Scholar 

  77. Mathew JL. Zinc supplementation for prevention or treatment of childhood pneumonia: A systematic review of randomized controlled trials. Indian Pediatr. 2010;47:61–66.

    Article  PubMed  Google Scholar 

  78. Roth DE, Richard SA, Black RE. Zinc supplementation for the prevention of acute lower respiratory infection in children in developing countries: meta-analysis and metaregression of randomized trials. Int J Epidemiol. 2010;39:795–808.

    Article  PubMed  Google Scholar 

  79. Lassi ZS, Haider BA, Bhutta ZA. Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months. Cochrane Database Syst Rev. 2010;12:CD005978.

    PubMed  Google Scholar 

  80. Chandyo RK, Shrestha PS, Valentiner-Branth P, Mathisen M, Basnet S, Ulak M, et al. Two weeks of zinc administration to Nepalese children with pneumonia does not reduce the incidence of pneumonia or diarrhea during the next six months. J Nutr. 2010;140:1677–1682.

    Article  PubMed  CAS  Google Scholar 

  81. Valentiner-Branth P, Shrestha PS, Chandyo RK, Mathisen M, Basnet S, Bhandari N, et al. A randomized controlled trial of the effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or nonsevere pneumonia in Bhaktapur, Nepal. Am J Clin Nutr. 2010;91:1667–1674.

    Article  PubMed  CAS  Google Scholar 

  82. Bansal A, Parmar VR, Basu S, Kaur J, Jain S, Saha A, Chawla D. Zinc supplementation in severe acute lower respiratory tract infection in children: a triple-blind randomized placebo controlled trial. Indian J Pediatr. 2011;78:33–37.

    Article  PubMed  Google Scholar 

  83. Mathew JL. Vitamin A supplementation for prophylaxis or therapy in childhood pneumonia: A systematic review of randomized controlled trials. Indian Pediatr. 2010;47:255–261.

    Article  PubMed  Google Scholar 

  84. Imdad A, Herzer K, Mayo-Wilson E, Yakoob MY, Bhutta ZA. Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age. Cochrane Database Syst Rev. 2010;12:CD008524

    PubMed  Google Scholar 

  85. Ni J, Wei J, Wu T. Vitamin A for non-measles pneumonia in children. Cochrane Database Syst Rev. 2005;3:CD003700.

    PubMed  Google Scholar 

  86. Cooper WO, Boyce TG, Wright PF, Griffin MR. Do childhood vaccines have non-specific effects on mortality? Bull WHO. 2003;81:821–826.

    PubMed  Google Scholar 

  87. Aaby P, Samb B, Simondon F, Seck AM, Knudsen K, Whittle H. Non-specific beneficial effect of measles immunisation: analysis of mortality studies from developing countries. BMJ.1995;311:481–485.

    PubMed  CAS  Google Scholar 

  88. Sudfeld CR, Navar AM, Halsey NA. Effectiveness of measles vaccination and vitamin A treatment. Int J Epidemiol. 2010;39Suppl 1: i48–i55.

    Article  PubMed  Google Scholar 

  89. Obonyo CO, Lau J. Efficacy of Haemophilus influenzae type b vaccination of children: a meta-analysis. Eur J Clin Microbiol Infect Dis. 2006;25:90–97.

    Article  PubMed  CAS  Google Scholar 

  90. Theodoratou E, Johnson S, Jhass A, Madhi SA, Clark A, Boschi-Pinto C, et al. The effect of Haemophilus influenzae type b and pneumococcal conjugate vaccines on childhood pneumonia incidence, severe morbidity and mortality. Int J Epidemio.l 2010;39Suppl 1:i172–i185.

    Article  Google Scholar 

  91. Swingler GH, Michaels D, Hussey GG. Conjugate vaccines for preventing Haemophilus influenzae type B infections. Cochrane Database Syst Rev. 2009;4:CD001729.

    PubMed  Google Scholar 

  92. Morris S, Moss W, Halsey N. Haemophilus influenzae type b conjugate vaccine use and effectiveness. Lancet Infect Dis. 2008;8:435–443.

    Article  PubMed  CAS  Google Scholar 

  93. Adegbola R, Secka O, Lahai G, Lloyd-Evans N, Njie A, Usen S. Elimination of Haemophilus influenzae type b (Hib) disease from The Gambia after the introduction of routine immunisation with a Hib conjugate vaccine: a prospective study. Lancet. 2005;366:144–150.

    Article  PubMed  Google Scholar 

  94. Gupta N, Puliyel J. WHO study suggests low incidence of Hib in India is due to natural immunity. Indian J Med Res. 2009;129:205.

    PubMed  Google Scholar 

  95. Gupta N, Puliyel JM. Vaccine introduction where incidence of Hib meningitis is 0.007%: decision-making based on health economic or ideology? Indian J Med Res. 2009;129:339–340.

    PubMed  Google Scholar 

  96. Bar-On ES, Goldberg E, Fraser A, Vidal L, Hellmann S, Leibovici L. Combined DTP-HBV-HIB vaccine versus separately administered DTP-HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B (HIB). Cochrane Database Syst Rev. 2009;3:CD005530.

    PubMed  Google Scholar 

  97. Lucero MG, Dulalia VE, Nillos LT, Williams G, Parreño RAN, Nohynek H, et al. Pneumococcal conjugate vaccines for preventing vaccine-type invasive pneumococcal disease and X-ray defined pneumonia in children less than two years of age. Cochrane Database Syst Rev. 2009;4:CD004977.

    PubMed  Google Scholar 

  98. Pavia M, Bianco A, Nobile CG, Marinelli P, Angelillo IF. Efficacy of pneumococcal vaccination in children younger than 24 months: a meta-analysis. Pediatrics. 2009;123:e1103–1110.

    Article  PubMed  Google Scholar 

  99. Destefano F, Pfeifer D, Nohynek H. Safety profile of pneumococcal conjugate vaccines: systematic review of pre- and post-licensure data. Bull WHO. 2008;86:373–380.

    PubMed  Google Scholar 

  100. Chaithongwongwatthana S, Yamasmit W, Limpongsanurak S, Lumbiganon P, Desimone JA, Baxter J, Tolosa JE. Pneumococcal vaccination during pregnancy for preventing infant infection. Cochrane Database Syst Rev. 2006;1:CD004903.

    PubMed  Google Scholar 

  101. Government of India. Ministry of Health and Family Welfare. National Program Implementation Plan RCH Phase II — Program Document. New Delhi: MOHFW; 2010.

    Google Scholar 

  102. India Clinical Epidemiology Network (IndiaCLEN) Task Force on Pneumonia. Rational use of antibiotics for pneumonia. Indian Pediatr. 2010;47:11–18.

    Article  Google Scholar 

  103. Hazir T, Fox LM, Nisar YB, Fox MP, Ashraf YP, MacLeod WB, et al.; New Outpatient Short-Course Home Oral Therapy for Severe Pneumonia Study Group. Ambulatory short-course high-dose oral amoxicillin for treatment of severe pneumonia in children: a randomised equivalency trial. Lancet. 2008;371:49–56.

    CAS  Google Scholar 

  104. F-Integrated Management of Neonatal & Childhood Illnesses. National Rural Health mission. http://mohfw.nic.in/NRHM/IMNCI/FIMNCI_index.htm. Accessed 12 Feb 2011.

  105. National Rural Health Mission, Govt of India. http://mohfw.nic.in/NRHM/ASHA_Kit.htm. Accessed 12 Feb 2011.

  106. National Rural Health Mission, Govt of India. http://mohfw.nic.in/NRHM/RCH/JRM_Final.htm. Accessed 12 Feb 2011.

  107. Blasi F, Iori I, Bulfoni A, Corrao S, Costantino S, Legnani D. Can CAP guideline adherence improve patient outcome in internal medicine departments? Eur Respir J. 2008;32:902–910.

    Article  PubMed  CAS  Google Scholar 

  108. Sazawal S, Black RE; Pneumonia Case Management Trials Group. Effect of pneumonia case management on mortality in neonates, infants, and preschool children: a metaanalysis of community-based trials. Lancet Infect Dis. 2003;3:547–556.

    Article  PubMed  Google Scholar 

  109. Bang AT, Bang RA, Sontakke PG. Management of childhood pneumonia by traditional birth attendants. The SEARCH Team. Bull World Health Organ. 1994;72:897–905.

    CAS  Google Scholar 

  110. Bang AT, Bang RA, Tale O, Sontakke P, Solanki J, Wargantiwar R, Kelzarkar P. Reduction in pneumonia mortality and total childhood mortality by means of community-based intervention trial in Gadchiroli, India. Lancet. 1990;336:201–206.

    Article  PubMed  CAS  Google Scholar 

  111. Darmstadt GL, Batra M, Zaidi AK. Oral antibiotics in the management of serious neonatal bacterial infections in developing country communities. Pediatr Infect Dis J. 2009;28:S31–S36.

    Article  PubMed  Google Scholar 

  112. Bell MH. Clinical diagnosis of pneumonia in children. Am Fam Phys. 2010;82:192–193.

    Google Scholar 

  113. Lynch T, Platt R, Gouin S, Larson C, Patenaude Y. Can we predict which children with clinically suspected pneumonia will have the presence of focal infiltrates on chest radiographs? Pediatrics. 2004;113(3 pt 1):e186–189.

    Article  PubMed  Google Scholar 

  114. Mathews B, Shah S, Cleveland RH, Lee EY, Bachur RG, Neuman MI. Clinical predictors of pneumonia among children with wheezing. Pediatrics. 2009;124:e29–36.

    Article  PubMed  Google Scholar 

  115. Shah D, Gupta P. Pertinent issues in diagnosis and management of wheezing in under-five children at community level. Indian Pediatr. 2010;47:56–60.

    Article  PubMed  Google Scholar 

  116. Sachdev HPS, Mahajan SC, Garg A. Improving antibiotic and bronchodilator prescription in children presenting with difficult breathing: Experience from an urban hospital in India. Indian Pediatr. 2001;38:827–838.

    PubMed  CAS  Google Scholar 

  117. Sachdev HPS, Vasanthi B, Satyanarayana L, Puri RK. Simple predictors to differentiate acute asthma from ARI in children: implications for refining case management in the ARI Control Program. Indian Pediatr. 1995;31:1251–1259.

    Google Scholar 

  118. Shah D, Sachdev HPS. Evaluation of the WHO/ UNICEF algorithm for integrated management of childhood illness between the ages of two months to five years. Indian Pediatr. 1999;36:767–777.

    PubMed  CAS  Google Scholar 

  119. CATCHUP Study Group (Co-trimoxazole Amoxicillin Trial in CHildren Under 5 years for Pneumonia). Clinical efficacy of co-trimoxazole versus amoxicillin twice daily for treatment of pneumonia: a randomized controlled clinical trial in Pakistan. Arch Dis Child.. 2002;86:113–118.

    Article  Google Scholar 

  120. Dongre AR, Deshmukh PR, Garg BS. Perceptions and health care seeking about newborn danger signs among mothers in rural Wardha. Indian J Pediatr. 2008;75:325–329.

    Article  PubMed  CAS  Google Scholar 

  121. Awasthi S, Agarwal G, Kabra SK, Singhi S, Kulkarni M, More V, et al. Does 3-day course of oral amoxicillin benefit children of non-severe pneumonia with wheeze: a multicentric randomised controlled trial. PLoS One. 2008;3:e1991.

    Article  PubMed  Google Scholar 

  122. Awasthi S, Srivastava NM, Pant S. Symptom-specific careseeking behavior for sick neonates among urban poor in Lucknow, Northern India. J Perinatol. 2008;28 Suppl 2:S69–S75.

    Article  Google Scholar 

  123. Pillai RK, Williams SV, Glick HA, Polsky D, Berlin JA, Lowe RA. Factors affecting decisions to seek treatment for sick children in Kerala, India. Soc Sci Med. 2003;57:783–790.

    Article  PubMed  Google Scholar 

  124. Mohan P, Iyengar SD, Agarwal K, Martines JC, Sen K. Care-seeking practices in rural Rajasthan: barriers and facilitating factors. J Perinatol. 2008;28Suppl 2:S31–S37.

    Article  PubMed  Google Scholar 

  125. Mishra S, Kumar H, Sharma D. How do mothers recognize and treat pneumonia at home? Indian Pediatr. 1994;31:15–18.

    PubMed  CAS  Google Scholar 

  126. Vissandjée B, Barlow R, Fraser DW. Utilization of health services among rural women in Gujarat, India. Public Health. 1997;111:135–148.

    Article  PubMed  Google Scholar 

  127. Srivastava NM, Awasthi S, Agarwal GG. Care-seeking behavior and out-of-pocket expenditure for sick newborns among urban poor in Lucknow, northern India: a prospective follow-up study. BMC Health Serv Res. 2009;9:61–65.

    Article  PubMed  Google Scholar 

  128. Sarma S. Demand for outpatient healthcare: empirical findings from rural India. Appl Health Econ Health Policy. 2009;7:265–267.

    PubMed  Google Scholar 

  129. Dalal K, Dawad S. Non-utilization of public health care facilities: examining the reasons through a national study of women in India. Rural Remote Health. 2009;9:1178–1181.

    PubMed  Google Scholar 

  130. Awasthi S, Srivastava NM, Agarwal GG, Pant S, Ahluwalia TP. Effect of behaviour change communication on qualified medical care-seeking for sick neonates among urban poor in Lucknow, northern India: a before and after intervention study. Trop Med Int Health. 2009;14:1199–1209.

    Article  PubMed  Google Scholar 

  131. Nath B, Singh JV, Awasthi S, Bhushan V, Singh SK, Kumar V. Client satisfaction with immunization services in urban slums of Lucknow district. Indian J Pediatr. 2009;76:479–483.

    Article  PubMed  Google Scholar 

  132. Mohan P, Iyengar SD, Martines J, Cousens S, Sen K. Impact of counseling on careseeking behaviour in families with sick children: cluster randomized trial in rural India. BMJ. 2004; 329:266.

    Article  PubMed  Google Scholar 

  133. Jain R, Awasthi S, Awasthi A. IMCI approach in tertiary hospitals, India. Indian J Pediatr. 2009;76:725–727.

    Article  PubMed  Google Scholar 

  134. Kumar D. Recognition and management of ARI—a KAP study on private medical practitioners. Indian J Pediatr. 1997;64:237–242.

    Article  PubMed  CAS  Google Scholar 

  135. Kumar R, Indira K, Rizvi A, Rizvi T, Jeyaseelan L. Antibiotic prescribing practices in primary and secondary health care facilities in Uttar Pradesh, India. J Clin Pharm Ther. 2008;33:625–634.

    Article  PubMed  CAS  Google Scholar 

  136. Das B, Sarkar C, Majumder AG. Medication use for pediatric upper respiratory tract infections. Fundam Clin Pharmacol. 2006;20:385–390.

    Article  PubMed  CAS  Google Scholar 

  137. Rehan HS, Lal P. Drug prescribing pattern of interns at a government healthcare center in northern India. Trop Doct. 2002;32:4–7.

    PubMed  Google Scholar 

  138. Sharma R, Chopra V S, Kour G. Use of antibiotics for respiratory illnesses in rural India. J Clin Diag Res. 2009;3:1557–1561.

    CAS  Google Scholar 

  139. Pandey MR, Daulaire NM, Starbuck ES, Houston RM, McPherson K. Reduction in total under-five mortality in western Nepal through community-based antimicrobial treatment of pneumonia. Lancet. 1991;338:993–997.

    Article  PubMed  CAS  Google Scholar 

  140. World Health Organization (2000) Handbook of IMCI (Integrated Management of Childhood Illnesses. Available from: http://202.54.104.236/intranet/eip/immunizationmanager/pdf/CAH_00_12_Ti_Contents.pdf. Accessed 15 Feb 2011.

  141. National Rural Health Mission, Govt of India. http://www.mohfw.nic.in/NRHM/Documents/Mission_Document.pdf. Accessed 15 Feb 2011.

  142. Bryce J, Gilroy K, Jones G, Hazel E, Black RE, Victora CG. The accelerated child survival and development program in west Africa: a retrospective evaluation. Lancet. 2010;375:572–582.

    Article  PubMed  Google Scholar 

  143. Harkins T, Drasbek C, Arroyo J, McQuestion M. The health benefits of social mobilization: experiences with community-based Integrated Management of Childhood Illness in Chao, Peru and San Luis, Honduras. Promot Educ. 2008;15:15–20.

    Article  PubMed  Google Scholar 

  144. Khan TA, Madni SA, Zaidi AK. Acute respiratory infections in Pakistan: have we made any progress? J Coll Physicians Surg Pak. 2004;14:440–448.

    PubMed  Google Scholar 

  145. Shimouchi A, Yaohua D, Zhonghan Z, Rabukawaqa VB. Effectiveness of control programs for pneumonia among children in China and Fiji. Clin Infect Dis. 1995;21Suppl 3:S213–S217.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Advanced Pediatrics Center, PGIMER, Chandigarh, 160 012, India

    Joseph L. Mathew

  2. International Health, Center for Global Health & Development, School of Public Health, Boston University, Boston, India

    Ashok K. Patwari

  3. University College of Medical Sciences, New Delhi, India

    Piyush Gupta & Dheeraj Shah

  4. Fortis Hospital, New Delhi, India

    Tarun Gera

  5. Max Hospital, Gurgaon, Haryana, India

    Siddhartha Gogia

  6. Delhi, India

    Pavitra Mohan

  7. Public Health Foundation of India, New Delhi, India

    Rajmohan Panda & Subhadra Menon

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  1. Joseph L. Mathew
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Mathew, J.L., Patwari, A.K., Gupta, P. et al. Acute respiratory infection and pneumonia in India: A systematic review of literature for advocacy and action: UNICEF-PHFI series on newborn and child health, India. Indian Pediatr 48, 191–218 (2011). https://doi.org/10.1007/s13312-011-0051-8

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