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Zinc supplementation for prevention or treatment of childhood pneumonia: A systematic review of randomized controlled trials

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References

  1. No authors listed. Pneumonia: the forgotten killer of children. Geneva: The United Nations Children’s Fund (UNICEF)/World Health Organization (WHO); 2006.

  2. Rudan I, Boschi-Pinto C, Biloglav Z, Mulholand K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bull WHO 2008; 86: 408–416.

    PubMed  Google Scholar 

  3. Zinc Investigators Collaborative Group. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. Am J Clin Nutr 2000; 72: 1516–1522.

    Google Scholar 

  4. Bhatnagar S, Lodha R, Choudhury P, Sachdev HPS, Shah N, Narayan S, et al. IAP Guidelines 2006 on management of acute diarrhea. Indian Pediatr 2007; 44: 384–389.

    Google Scholar 

  5. World Health Organization Department of Child and Adolescent Health and Development. Clinical management of acute diarrhoea: WHO/UNICEF joint statement [WHO/FCH/CAH/04.7]. Geneva: World Health Organization; 2004.

    Google Scholar 

  6. Brooks WA, Santosham M, Naheed A, Goswami D, Wahed MA, Diener-West M, et al. Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial. Lancet 2005; 366: 999–1004.

    Article  CAS  PubMed  Google Scholar 

  7. Baqui AH, Black RE, El Arifeen S, Yunus M, Chakraborty J, Ahmed S, et al. Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. BMJ 2002; 325: 1059–1065.

    Article  CAS  PubMed  Google Scholar 

  8. Osendarp SJ, Santosham M, Black RE, Wahed MA, van Raaij JM, Fuchs GJ. Effect of zinc supplementation between 1 and 6 mo of life on growth and morbidity of Bangladeshi infants in urban slums. Am J Clin Nutr 2002; 76: 1401–1408.

    CAS  PubMed  Google Scholar 

  9. Bhandari N, Bahl R, Taneja S, Strand T, Mølbak K, Ulvik RJ, et al. Effect of routine zinc supplementation on pneumonia in children aged 6 months to 3 years: randomised controlled trial in an urban slum. BMJ 2002; 324: 1358–1362.

    Article  CAS  PubMed  Google Scholar 

  10. Rahman MM, Vermund SH, Wahed MA, Fuchs GJ, Baqui AH, Alvarez JO. Simultaneous zinc and vitamin A supplementation in Bangladeshi children: randomised double blind controlled trial. BMJ 2001; 323: 314–318.

    Article  CAS  PubMed  Google Scholar 

  11. Richard SA, Zavaleta N, Caulfield LE, Black RE, Witzig RS, Shankar AH. Zinc and iron supplementation and malaria, diarrhea, and respiratory infections in children in the Peruvian Amazon. Am J Trop Med Hyg 2006; 75: 126–132.

    CAS  PubMed  Google Scholar 

  12. Taneja S, Bhandari N, Rongsen-Chandola T, Mahalanabis D, Fontaine O, Bhan MK. Effect of zinc supplementation on morbidity and growth in hospital-born, low-birth-weight infants. Am J Clin Nutr 2009; 90: 385–391.

    Article  CAS  PubMed  Google Scholar 

  13. Sazawal S, Black RE, Jalla S, Mazumdar S, Sinha A, Bhan MK. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial. Pediatrics 1998; 102: 1–5.

    Article  CAS  PubMed  Google Scholar 

  14. Lind T, Lönnerdal B, Stenlund H, Gamayanti IL, Ismail D, Seswandhana R, et al. A communitybased randomized controlled trial of iron and zinc supplementation in Indonesian infants: effects on growth and development. Am J Clin Nutr 2004; 80: 729–736.

    CAS  PubMed  Google Scholar 

  15. Penny ME, Marin RM, Duran A, Peerson JM, Lanata CF, Lönnerdal B, et al. Randomized controlled trial of the effect of daily supplementation with zinc or multiple micronutrients on the morbidity, growth, and micronutrient status of young Peruvian children. Am J Clin Nutr 2004; 79: 457–465.

    CAS  PubMed  Google Scholar 

  16. Roy SK, Tomkins AM, Akramuzzaman SM, Chakraborty B, Ara G, Biswas R, et al. Impact of zinc supplementation on subsequent morbidity and growth in Bangladeshi children with persistent diarrhoea. J Health Popul Nutr 2007; 25: 67–74.

    CAS  PubMed  Google Scholar 

  17. World Health Organization. Division of Child Health and Development. Integrated management of childhood illness. Geneva, Switzerland: World Health Organization; 1997. (Document ref. WHO/CHD/97.3E.)

    Google Scholar 

  18. Brooks WA, Yunus M, Santosham M, Wahed MA, Nahar K, Yeasmin S, et al. Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Lancet 2004; 363: 1683–1688.

    Article  CAS  PubMed  Google Scholar 

  19. Chang AB, Torzillo PJ, Boyce NC, White AV, Stewart PM, Wheaton GR, et al. Zinc and vitamin A supplementation in indigenous Australian children hospitalised with lower respiratory tract infection: a randomised controlled trial. Med J Aust 2006; 184: 107–112.

    PubMed  Google Scholar 

  20. Bose A, Coles CL, Gunavathi, John H, Moses P, Raghupathy P, et al. Efficacy of zinc in the treatment of severe pneumonia in hospitalized children <2 y old. Am J Clin Nutr 2006; 83: 1089–1096.

    CAS  PubMed  Google Scholar 

  21. Mahalanabis D, Chowdhury A, Jana S, Bhattacharya MK, Chakrabarti MK, Wahed MA, et al. Zinc supplementation as adjunct therapy in children with measles accompanied by pneumonia: a double-blind, randomized controlled trial. Am J Clin Nutr 2002; 76: 604–607.

    CAS  PubMed  Google Scholar 

  22. Bhutta ZA, Black RE, Brown KH, Gardner JM, Gore S, Hidayat A, et al. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. J Pediatr 1999; 135: 689–697.

    Article  CAS  PubMed  Google Scholar 

  23. Aggarwal R, Sentz J, Miller MA. Role of zinc administration in prevention of childhood diarrhea and respiratory illnesses: a metaanalysis. Pediatrics 2007; 119: 1120–1130.

    Article  PubMed  Google Scholar 

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  1. Advanced Pediatrics Centre, PGIMER, Chandigarh, 160012, India

    Joseph L. Mathew

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  1. Joseph L. Mathew
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Correspondence to Joseph L. Mathew.

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Mathew, J.L. Zinc supplementation for prevention or treatment of childhood pneumonia: A systematic review of randomized controlled trials . Indian Pediatr 47, 61–66 (2010). https://doi.org/10.1007/s13312-010-0004-7

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  • DOI: https://doi.org/10.1007/s13312-010-0004-7

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