Abstract
A prospective one year study was performed on 62 children admitted at the Alt India institute of Medical Sciences with community acquired pneumonia (CAP) for the prevalence ofMycoplasma pneumoniae andChlamydia pneumoniae.
Diagnosis of infection withM. pneumonias was based on serological tests viz microparticle agglutination test for detection of IgM antibodies and indirect immunofluorescence test for antigen detection from throat swabs (sensitivity 85.7%, specificity 93.3%). The indirect solid-phase enzyme immunoassay for detection of IgG antibodies was used to determine the prevalence ofC. pneumoniae (sensitivity 88.8%, specificity 75.8%).
Seventeen patients (27.4%) were found to have serotogical evidence ofM. pneumoniae infection whereas only 4 (6.4%) patients were seropositive forC. pneumoniae. Results of this study indicate thatM. Pneumoniae piays a significant role in CAP in infants and young children. Thus specialized laboratory testing for these agents should be more widely used thereby affecting empiric antibiotic regimens.
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References
World Health Organization. Acute Respiratory Infections in-children: Case management in small hospitals in developing countries. A manual for doctors and other senior health workers.WHO Geneva 1990.
Patwari AK, Bisht S, Srinivasan A, Deb M, Chattopadhya D. Aetiology of pneumonia in hospitalised children.Trap Ped. 1996; 42:15–20.
Kumar L. Severe acute lower respiratory infections,: Etiology and management.hid J Pediat 1987; 54:189–198.
Gupta U, Vishnava S, Gulati AK.Mycoplasma pneumoniae infection in infants and children.Indian J Med Res 1975; 63: 385–389.
Barker CE, Sillis M, Wreghitt TG. Evaluation of serodia Myco II particle agglutination test for detectingMycoplasmapnenmoniae antibody: comparison with u-capture ELISA and indirect immunofluoresences.J Clin Pathol 1990; 43 :163–165.
Hirai Y, Shiode J, Masayoshi T, Kanemasa Y. Application of an indirect immunbfluoreseence test for detection ofMycoplasma pneumoniae in respiratory exudates.J Clin Microbiol 1991; 29: 2007–2017.
Wang JH, Liu YC, Cheng DL, Yeng MY, Chen YS. Chen BO. Seroprevalence ofChlamydia pneumoniae in Taiwan.Scand J Infect Dis 1993; 25: 565–568.
Fransen H. Clinical and laboratory studies on the role of viruses, bacteria.Mycoplasma pneunoniae and Bedsonia in acute respiratory illness.Scand J Infect Dis 1970; 2:1–38.
Ayyagari A, Gupta U, Mohapatra LN, Balaya S, Bajaj S. A study of the role of bacteria, viruses andMycoplasma pneumoniae in infants and children suffering from pneumonia.Indian J Med Res 1972; 60: 1750–1754.
Nagayama Y, Sakurai N, Yamamota K, Honda A, Makuta M. Suzuki R. Isolation ofMycoplasma pneumoniae from children with lower respiratory tract infectionsJ Infect Dis 1988; 157: 911–917.
Wreghitt TG, Sillis M. An investigation of theMycoplasma pneumoniae infectioris in Cambridge in 1983 using μ-capture ELI SA, indirect immunofluorescence and complement fixation tests.I Sr J Med Sci 1987; 23: 704–708.
Noah ND.Mycoplasma pneumoniae infection in the United Kingdom-1967-1973.Br Med J 1974; 2: 544–546.
Herrmann B, Salih MAM, Yousef BE, Abdelwahab Q, Mardh PA. Chlamydial etiology of acute lower respiratory tract infections in children in Sudan.Acta Paediatr 1994; 83:169–172.
Yamada S.Chlamydia pneumoniae infection in children with lower respiratory tract infections,Kurume Med J 1995; 42: 107–120
Saikku P, Ruutu P, Leinonen M, Panulius P, Tupasi TE, Grayston JT. Acute Towerrespiratory tract infection associated with chlamydial TWAR antibody in Filipino children.J Infect Dis 1988; 158: 1095–1097.
Berdal BP, Scheel Q, Ogaard AR, Hel T, Gutteberg TJ, Anestad G. Spread of subclinical Chlamydia, pneumoniae infection in a close communityScand J Infect Dis 1992; 24:431–436.
Van Renterghem L, Van den Abeele AM, Claeys G, Plum J. Prevalence of antibodies toChlamydia pneumoniae in a pediatric hospital population in Belgium.Eur J Clin Microbiol Infect Dis 1990 ; 9: 347–349.
Jegathesan M. Practical issues in the determination of the aetiology of acute respiratory infections. In : Douglas RM, Kerby Eaton E, eds.Acute Respiratory Infections in Childhood. Proceedings of an international workshop, Sydney 1984, Univ. of Adelaide, 1985; 30–32.
Sherman Avni Y, Lieberman D.Chlamydia pneumoniae induced cilostasis in ciliated bronchial epithelial cells.J Infect Dis 1995; 17:1274–1278.
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Chaudhry, R., Nazima, N., Dhawan, B. et al. Prevalence ofMycoplasma pneumoniae andChlamydia pneumoniae in children with community acquired pneumonia. Indian J Pediatr 65, 717–721 (1998). https://doi.org/10.1007/BF02731050
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DOI: https://doi.org/10.1007/BF02731050