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Rap2B GTPase: structure, functions, and regulation

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Tumor Biology

Abstract

Rap2B GTPase, a member of Ras-related protein superfamily, was first discovered from a platelet cDNA library in the early 1990s. Since then, it has been reported to play an important role in regulating cellular processes including cytoskeletal organization, cell growth, and proliferation. It can be stimulated and suppressed by a wide range of external and internal inducers, circulating between GTP-bound active state and GDP-bound inactive state. Increasing focus on Ras signaling pathway reveals critical effects of Rap2B on tumorigenesis. In particular, Rap2B behaves in a p53-dependent manner in regulation of apoptosis and migration. Apart from being an oncogenic activator, Rap2B has been found to participate in many other physiological events via diverse downstream effectors. In this review, we present recent studies on the structure, regulation, and multiple biological functions of Rap2B, shedding light on its potential status in treatment of cancer as well as other diseases.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (nos. 81201637) and Natural Science Foundation for colleges and universities in Jiangsu Province (no. 14KJB320023). Jiehui Di was sponsored by the Qing Lan Project of Jiangsu Province.

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    Authors and Affiliations

    1. Cancer Institute, Xuzhou Medical College, Xuzhou, 221002, Jiangsu, China

      Zhesi Zhu, Jiehui Di, Zheng Lu & Keyu Gao

    2. Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical College, Xuzhou, 221002, Jiangsu, China

      Junnian Zheng

    3. Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China

      Junnian Zheng

    4. Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina at Chapel Hill, 101 Manning Drive, Chapel Hill, NC, 27514, USA

      Jiehui Di

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    5. Junnian Zheng
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    Correspondence to Junnian Zheng.

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    Zhesi Zhu and Jiehui Di contributed equally to this work.

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    Zhu, Z., Di, J., Lu, Z. et al. Rap2B GTPase: structure, functions, and regulation. Tumor Biol. 37, 7085–7093 (2016). https://doi.org/10.1007/s13277-016-5033-y

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    • DOI: https://doi.org/10.1007/s13277-016-5033-y

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