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Inhibitor of growth-4 is a potential target for cancer therapy

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Tumor Biology

Abstract

The inhibitor of growth-4 (ING-4) belongs to the inhibitor of growth (ING) family that is a type II tumor suppressor gene including five members (ING1-5). As a tumor suppressor, ING4 inhibits tumor growth, invasion, and metastasis by multiple signaling pathways. In addition to that, ING4 can facilitate cancer cell sensitivity to chemotherapy and radiotherapy. Although ING4 loss is observed for many types of cancers, increasing evidences show that ING4 can be used for gene therapy. In this review, the recent progress of ING4 regulating tumorigenesis is discussed.

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Acknowledgments

This work was supported by the Jiangsu Province Natural Science Foundation (BK20131251) and by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.

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Authors and Affiliations

  1. Department of Oncology, Affiliated Wujin People’s Hospital, Jiangsu University, Changzhou, 212017, China

    Shuping Yuan, Jianhua Jin & Yongzhong Hou

  2. Institute of Life Sciences, Jiangsu University, Zhenjiang, 212013, China

    Shuping Yuan, Juanjuan Shi & Yongzhong Hou

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  1. Shuping Yuan
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  2. Jianhua Jin
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Yuan, S., Jin, J., Shi, J. et al. Inhibitor of growth-4 is a potential target for cancer therapy. Tumor Biol. 37, 4275–4279 (2016). https://doi.org/10.1007/s13277-016-4842-3

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