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Detection of DNA repair protein in colorectal cancer of patients up to 50 years old can increase the identification of Lynch syndrome?

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Tumor Biology

Abstract

The aim of this study was to compare the results of protein level of the DNA mismatch repair genes with the clinical diagnosis of Lynch syndrome according to the Amsterdam II criteria in patients 50 years and younger who underwent surgery for colorectal cancer. The subjects of analysis were 48 patients 50 years old and younger. Immunohistochemistry assays were performed to detect proteins from the DNA mismatch repair genes. Clinicopathological data and Amsterdam II criteria for the diagnosis of hereditary nonpolyposis colorectal cancer were obtained by analyzing medical records. Two (4 %) patients satisfied the Amsterdam II criteria for Lynch syndrome, and both presented levels of all of the studied mismatch repair proteins. A total of 13 (27 %) patients exhibited the absence of protein levels of the studied mismatch repair genes. None of these patients were considered suspicious for Lynch syndrome according to the Amsterdam II criteria. Screening for the level of proteins of the mismatch repair system in all colorectal cancer patients 50 years and younger can increase the identification of patients with suspicion of Lynch syndrome.

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Authors and Affiliations

  1. Department of Surgery, São Paulo State Civil Servant Hospital, Rua Augusto de Miranda, 1303 ap. 22 Pompéia, São Paulo, SP, 05026-001, Brazil

    Demétrius Eduardo Germini

  2. Department of Pathology, ABC Medical School, Avenida Príncipe de Gales, 821, Santo André, SP, 09080-650, Brazil

    Ana Maria Amaral Antônio Mader

  3. Department of Surgery, ABC Medical School, Avenida Príncipe de Gales, 821, Santo André, SP, 09080-650, Brazil

    Luiz Guilherme Lisboa Gomes & Jaques Waisberg

  4. Department of Morphology, ABC Medical School, Avenida Príncipe de Gales, 821, 09080650, Santo André, SP, Brazil

    Thérèse Rachel Teodoro

  5. Department of Pathology, São Paulo State Civil Servant Hospital, Avenida Ibirapuera, 981, São Paulo, SP, 04029-000, Brazil

    Maria Isete Fares Franco

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  1. Demétrius Eduardo Germini
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Correspondence to Demétrius Eduardo Germini.

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Germini, D.E., Mader, A.M.A.A., Gomes, L.G.L. et al. Detection of DNA repair protein in colorectal cancer of patients up to 50 years old can increase the identification of Lynch syndrome?. Tumor Biol. 37, 2757–2764 (2016). https://doi.org/10.1007/s13277-015-4108-5

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  • DOI: https://doi.org/10.1007/s13277-015-4108-5

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