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RETRACTED ARTICLE: Diagnostic procedures for improving of the KIT (CD117) expressed allele burden for the liver metastases from uterus mast cell tumors: prognostic value of the metastatic pattern and tumor biology

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Tumor Biology

This article was retracted on 05 November 2016

Abstract

The activating KIT marker plays a central role in the pathogenesis, diagnosis, and targeted treatment of systemic mastocytosis (SM). Recent studies have identified the KIT (CD117) as a marker that distinguishes nonneoplastic from neoplastic mast cells in human systemic mastocytosis. In this study, we conclude that immunohistopathology assays for KIT staining pattern are useful complimentary tools for diagnosis and evaluation of prognosis in uterus mast cell tumor (MCT) metastasis to the liver in 10 patients. Uterine and hepatic cytology revealed mast cell neoplasia, which was confirmed as visceral mast cell tumor on postmortem examination. Histological changes of densely packed, poorly differentiated neoplastic mast cells, sheets of neoplastic round to pleomorphic cells that formed nonencapsulated nodules, high mitotic figures, necrosis, and fibrosis were found. In addition, eosinophils were scattered among the mast cells at the periphery of the nodules. These findings indicate tumors of high-grade malignancy with infiltrative cells resembling the uterus MCT in the intraparenchymal and periparenchymal areas of the liver. Immunohistochemically, tumors were positive for KIT. The histopathologic features coupled with the KIT immunoreactivity led to diagnosis of high-grade uterus MCTs. Taken together, these findings suggest that CD117 may play a critical role in early uterus MCT development and may be a stimulatory factor in grade 3 MCT. Therefore, the result has supported our hypothesis that there was an increased opportunity to observe a higher CD117 staining pattern in high-grade MCTs.

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Acknowledgments

The authors thank Dr. Javad Javanbakht for his help with this manuscript.

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Faculty of Para Veterinary Medicine, Ilam University, Ilam, Iran

    Ehsan Hosseini & Ali Mohammad Bahrami

  2. Department of Pathobiology, Susangerd Branch, Islamic Azad University, Susangerd, Iran

    Behnam Pedram

  3. Department of Basic Science, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

    Seyed Rashid Touni

  4. Department of Internal Medicine, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

    Hamed Zamankhan Malayeri

  5. Department of Immunology, Faculty of Medicine, and Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran

    Aram Mokarizadeh

  6. Faculty of Veterinary Science, Karaj Branch, Islamic Azad University, Alborz, Iran

    Mehdi Pourzaer

  7. Department of Biology, Faculty of Basic Science, Damghan Branch, Islamic Azad University, Damghan, Iran

    Maryam Pourzaer

  8. Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Shahram Zehtabian

  9. Chronic Respiratory Disease Research Center, National Research Institue of Tuberculosis and Lung Diseases, Massih Daneshvary Hospital, Shahid Beheshti University of Medicine, Tehran, Iran

    Sheida Mohajer

  10. Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Sharareh Ahmadi

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  1. Ehsan Hosseini
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Corresponding authors

Correspondence to Ali Mohammad Bahrami or Aram Mokarizadeh.

Additional information

This article has been retracted at the request of the Editor-in-Chief, the International Society of Oncology and BioMarkers (ISOBM) and the Publisher per the Committee on Publication Ethics guidelines. The article shows evidence of irregularities in authorship during the submission process, there is strong reason to believe that the peer review process was compromised and the article contains patchwork plagiarism from a variety of sources.

The main sources are (amongst others): Ehsan Hosseini, Behnam Pedram, Ali Mohammad BahramiEmail author, Mohammad Hossein Jaberi Moghaddam, Javad Javanbakht, Fatemeh Emami Ghomi, Najme Jaberi Moghaddam, Mobin Koohestani and Radmehr Shafiee, Cutaneous mast cell tumor (Mastocytoma): Cyto- histopathological and haematological investigations. Tumor Biol. 2014; 9:9 DOI: 10.1186/1746-1596-9-9

Catherine G. Lamm, Adam W. Stern, Amanda J. Smith, Emily J. Cooper, Steven W. Ullom, Gregory A. Campbell, Disseminated Cutaneous Mast Cell Tumors with Epitheliotropism and Systemic Mastocytosis in a Domestic Cat, Journal of Veterinary Diagnostic Investigation. 2009; 21:5 710-715 DOI: 10.1177/104063870902100520

Tzu-Yin Lin, Alexander Hamberg, Rebecca Pentecost, Maxey Wellman, Paul Stromberg, Mast Cell Tumors in a Llama (Lama Glama), Journal of Veterinary Diagnostic Investigation 2010; 22:5 808-811 DOI: 10.1177/104063871002200531

Mery Giantin, Marta Vascellari, Emanuela Maria Morello, Katia Capello, Antonella Vercelli, Anna Granato Rosa Maria Lopparelli, Chiara Nassuato, Antonio Carminato, Marina Martano, Franco Mutinelli, Mauro Dacasto, c-KIT messenger RNA and protein expression and mutations in canine cutaneous mast cell tumors correlations with post-surgical prognosis, Journal of Veterinary Diagnostic Investigation January, 2012; 24:1 116-126 doi:10.1177/1040638711425945

M. Giantin, L. Aresu, S. Benali, A. Aricò, E.M. Morello, M. Martano, M. Vascellari, M. Castagnaro, R.M. Lopparelli, V. Zancanella, A. Granato, F. Mutinelli, M. Dacasto, Expression of Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases and Vascular Endothelial Growth Factor in Canine Mast Cell Tumours, Journal of Comparative Pathology. 2012; 147:4 419–429 DOI: 10.1016/j.jcpa.2012.01.011

In addition, figure 9 “Uterus: canine, mast cell tumor. Diffuse cytoplasmic KIT localization and cells expressing KIT are identified by blue labeling. The majority of neoplastic mast cells express KIT marker within the cytoplasm, often obscuring the nucleus. ×400 magnification” and figure 10 “Fine-needle aspirate smear of a uterus mass from the mast cell tumor of a dog. There are many large round cells with centrally placed round nuclei, clear cytoplasm, pleomorphism, and poorly differentiated

mast cells” are duplicating: 13048_2014_105_MOESM9_ESM.png Authors’ original file for figure 9 (online resource) 13048_2014_105_MOESM10_ESM.png Authors’ original file for figure 10 (online resource)

Published in: Ali Mohammad Bahrami, Fariba Khaki, Shahram Zehtabian, Javad Cheraghi, Mehdi Rashnavadi, Mohammad Reza Hafezi Ahmadi, Mostafa Naderafif, Soheil Javaherypour, Siamak Mohsenzadeh, Ehsan Hosseini, Hamed Masoudi, Mehdi Pourzaer, Uterine mast cell tumor: a clinical and cytohistopathological study, Journal of Ovarian Research 2014; 7:105 DOI: 10.1186/s13048-014-0105-3 http://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-014-0105-3 (online resource)

As such the validity of the content of this article cannot be verified.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-016-5474-3.

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Hosseini, E., Pedram, B., Bahrami, A.M. et al. RETRACTED ARTICLE: Diagnostic procedures for improving of the KIT (CD117) expressed allele burden for the liver metastases from uterus mast cell tumors: prognostic value of the metastatic pattern and tumor biology. Tumor Biol. 36, 929–937 (2015). https://doi.org/10.1007/s13277-014-2666-6

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