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The lncRNA-MYC regulatory network in cancer

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  • Published:
Tumor Biology

Abstract

Long non-coding RNAs (lncRNAs) have been widely studied in recent years, and accumulating evidence identified lncRNAs as crucial regulators of various biological processes, including cell cycle progression, chromatin remodeling, gene transcription, and posttranscriptional processing. In addition, the fact that lncRNAs interact with the MYC gene family in human carcinomas has been discovered. This review summarizes the latest progress on the investigation of lncRNAs and MYC, particularly focusing on the interplay between lncRNAs and MYC in cancer to reveal the significance of lncRNA-MYC network in regulating initiation, development, and metastasis of tumors. Further research and collection of clinical data would provide a better understanding of lncRNA-MYC network in cancer diagnosis and treatment.

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  1. Department of General Surgery and Translational Medicine Center, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi, 214002, Jiangsu, China

    Kaiyuan Deng, Xiaoqiang Guo, Hao Wang & Jiazeng Xia

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Deng, K., Guo, X., Wang, H. et al. The lncRNA-MYC regulatory network in cancer. Tumor Biol. 35, 9497–9503 (2014). https://doi.org/10.1007/s13277-014-2511-y

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