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Low expression of let-7 predicts poor prognosis in patients with multiple cancers: a meta-analysis

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Tumor Biology

Abstract

The connection between microRNA expression and cancers has been identified, and microRNAs may be considered as important prognostic biomarkers. However, it is still inconsistent whether expression of let-7 can predict prognosis in patients with multiple cancers. A meta-analysis was performed by searching PubMed, EMBASE, and ISI Web of Science databases. All data were extracted from articles comparing prognosis in patients with multiple cancers having low expression of let-7 with those having high expression. Pooled hazard ratios (HRs) and corresponding 95 % confidence intervals (CIs) were calculated. Subgroup analyses were conducted for cancer type and ethnicity. A total of 1,757 cases of multiple cancers were involved for this meta-analysis. The HR of low let-7 expression in multiple cancers was 1.80 (95 % CI 1.18–2.76), and that in lung cancer was 1.99 (95 % CI 1.17–3.40). A subgroup analysis was performed on ethnicity; combined HR was 1.61 (95 % CI 0.84–3.11) for Asians and 1.94 (95 % CI 1.11–3.39) for non-Asians. Low expression of let-7 might predict poor prognosis in patients with multiple cancers, especially in lung cancer. Furthermore, let-7 might be a biomarker in non-Asian patients with favorable prognosis.

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References

  1. Yang W, Lee DY, Ben-David Y. The roles of microRNAs in tumorigenesis and angiogenesis. Int J Physiol Pathophysiol Pharmacol. 2011;3:140–55.

    PubMed Central  CAS  PubMed  Google Scholar 

  2. Hong L, Han Y, Zhang H, Li M, Gong T, Sun L, et al. The prognostic and chemotherapeutic value of miR-296 in esophageal squamous cell carcinoma. Ann Surg. 2010;251:1056–63.

    Article  PubMed  Google Scholar 

  3. Liu R, Liao J, Yang M, Sheng J, Yang H, Wang Y, et al. The cluster of miR-143 and miR-145 affects the risk for esophageal squamous cell carcinoma through co-regulating fascin homolog 1. PloS one. 2012;7:e33987.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, et al. MicroRNA expression profiles classify human cancers. Nature. 2005;435:834–8.

    Article  CAS  PubMed  Google Scholar 

  5. Sugimura K, Miyata H, Tanaka K, Hamano R, Takahashi T, Kurokawa Y, et al. Let-7 expression is a significant determinant of response to chemotherapy through the regulation of IL-6/STAT3 pathway in esophageal squamous cell carcinoma. Clin Cancer Res. 2012;18:5144–53.

    Article  CAS  PubMed  Google Scholar 

  6. Lee JY, Kim HJ, Yoon NA, Lee WH, Min YJ, Ko BK, et al. Tumor suppressor p53 plays a key role in induction of both tristetraprolin and let-7 in human cancer cells. Nucleic Acids Res. 2013;41:5614–25.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Kong D, Heath E, Chen W, Cher ML, Powell I, Heilbrun L, et al. Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM. PloS one. 2012;7:e33729.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Chan HW, Lappas M, Yee SW, Vaswani K, Mitchell MD, Rice GE. The expression of the let-7 miRNAs and Lin28 signalling pathway in human term gestational tissues. Placenta. 2013;34:443–8.

    Article  CAS  PubMed  Google Scholar 

  9. Jiang Y, Qin Z, Hu Z, Guan X, Wang Y, He Y, et al. Genetic variation in a hsa-let-7 binding site in RAD52 is associated with breast cancer susceptibility. Carcinogenesis. 2013;34:689–93.

    Article  CAS  PubMed  Google Scholar 

  10. He XY, Chen JX, Zhang Z, Li CL, Peng QL, Peng HM. The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice. J Cancer Res Clin Oncol. 2010;136:1023–8.

    Article  CAS  PubMed  Google Scholar 

  11. Pan L, Gong Z, Zhong Z, Dong Z, Liu Q, Le Y, et al. Lin-28 reactivation is required for let-7 repression and proliferation in human small cell lung cancer cells. Mol Cell Biochem. 2011;355:257–63.

    Article  CAS  PubMed  Google Scholar 

  12. Fu X, Han Y, Wu Y, Zhu X, Lu X, Mao F, et al. Prognostic role of microRNA-21 in various carcinomas: a systematic review and meta-analysis. Eur J Clin Invest. 2011;41:1245–53.

    Article  CAS  PubMed  Google Scholar 

  13. Xu W, Xu J, Liu S, Chen B, Wang X, Li Y, et al. Effects of common polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on cancer susceptibility: a meta-analysis. PloS one. 2011;6:e20471.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Nair VS, Maeda LS, Ioannidis JP. Clinical outcome prediction by microRNAs in human cancer: a systematic review. J Natl Cancer Inst. 2012;104:528–40.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Yang M, Shen H, Qiu C, Ni Y, Wang L, Dong W, et al. High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer. Eur J Cancer. 2013;49:604–15.

    Article  CAS  PubMed  Google Scholar 

  16. Cui EH, Li HJ, Hua F, Wang B, Mao W, Feng XR, et al. Serum microRNA 125b as a diagnostic or prognostic biomarker for advanced NSCLC patients receiving cisplatin-based chemotherapy. Acta Pharmacol Sin. 2013;34:309–13.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  17. Hayes DF, Isaacs C, Stearns V. Prognostic factors in breast cancer: current and new predictors of metastasis. J Mammary Gland Biol Neoplasia. 2001;6:375–92.

    Article  CAS  PubMed  Google Scholar 

  18. Voortman J, Goto A, Mendiboure J, Sohn JJ, Schetter AJ, Saito M, et al. Microrna expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma. Cancer research. 2010;70:8288–8298.

    Google Scholar 

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Authors and Affiliations

  1. Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210000, China

    Yang Xia, Yi Zhu & Yijiang Chen

  2. Department of Thoracic and Cardiovascular Surgery, Huai’an Hospital Affiliated of Xuzhou Medical College and Huai’an Second People’s Hospital, Huai’an, 223002, China

    Yi Zhu

  3. Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210000, China

    Xiaoying Zhou

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  1. Yang Xia
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  2. Yi Zhu
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Correspondence to Yijiang Chen.

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Yang Xia, Yi Zhu, and Xiaoying Zhou contributed equally to this work.

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Xia, Y., Zhu, Y., Zhou, X. et al. Low expression of let-7 predicts poor prognosis in patients with multiple cancers: a meta-analysis. Tumor Biol. 35, 5143–5148 (2014). https://doi.org/10.1007/s13277-014-1663-0

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  • DOI: https://doi.org/10.1007/s13277-014-1663-0

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