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Quantitative assessment of the association between XPG Asp1104His polymorphism and bladder cancer risk

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Tumor Biology

Abstract

Published data regarding the association between XPG Asp1104His polymorphism and bladder cancer risk remained controversial. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, and Web of Science with a time limit of June 22, 2013. Summary odds ratios (ORs) with 95 % CIs were used to assess the strength of the association between XPG Asp1104His polymorphism and bladder cancer risk using random effects model. A total of eight case–control studies including 2,613 cases and 2,934 controls were included for analysis. Overall, no significant association was found between XPG Asp1104His polymorphism and bladder cancer susceptibility for CC vs. GG (OR = 1.12, 95 % CI = 0.74–1.69), GC vs. GG (OR = 1.12, 95 % CI = 0.86–1.46), the dominant model CC + GC vs. GG (OR = 1.08, 95 % CI = 0.85–1.38), and the recessive model CC vs. GC + GG (OR = 0.92, 95 % CI = 0.66–1.29). In the subgroup analysis, no significant associations were found in either Asian or non-Asian population. This meta-analysis suggested that XPG Asp1104His polymorphism was not associated with bladder cancer risk.

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Acknowledgments

This study was supported by the Natural Science Foundation of The People’s Republic of China (no. 81072175 and no.81202096). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Department of Oncology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, People’s Republic of China

    Chuan Liu & Yajie Wang

  2. Department of Oncology, The First People’s Hospital of Yueyang, Baling Middle Rd, Yueyanglou, Yueyang, Hunan, People’s Republic of China

    Qinghua Yin, Jianbing Hu & Jie Weng

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  1. Chuan Liu
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  2. Qinghua Yin
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  3. Jianbing Hu
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  4. Jie Weng
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  5. Yajie Wang
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Corresponding author

Correspondence to Yajie Wang.

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Chuan Liu and Qinghua Yin contributed equally to the study.

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Liu, C., Yin, Q., Hu, J. et al. Quantitative assessment of the association between XPG Asp1104His polymorphism and bladder cancer risk. Tumor Biol. 35, 1203–1209 (2014). https://doi.org/10.1007/s13277-013-1161-9

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  • DOI: https://doi.org/10.1007/s13277-013-1161-9

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