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NBS1 Glu185Gln polymorphism and susceptibility to urinary system cancer: a meta-analysis

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Tumor Biology

Abstract

A number of studies have investigated the association between the NBS1 Glu185Gln (rs1805794, 8360 G > C) polymorphism and risk for urinary system cancer including bladder cancer, prostate cancer, and renal cell cancer; however, the findings are conflicting. We conducted a meta-analysis focusing on eight published studies with 3,542 cases and 4,210 controls to derive a more precise evaluation of the relationship between the NBS1 Glu185Gln polymorphism and urinary system cancer susceptibility. Overall, the NBS1 Glu185Gln polymorphism was significantly related to increased risk for urinary system cancer (homozygous model: odds ratio (OR) = 1.23, 95 % confidence interval (95 % CI) = 1.05–1.44, p = 0.011; heterozygous model: OR = 1.14, 95 % CI = 1.04–1.26, p = 0.008; dominant model: OR = 1.16, 95 % CI = 1.05–1.27, p = 0.002; and Gln vs. Glu: OR = 1.12, 95 % CI = 1.04–1.20, p = 0.002) and further stratification analysis indicated an increased risk for bladder cancer (heterozygous model: OR = 1.13, 95 % CI = 1.02–1.26, p = 0.022; dominant model: OR = 1.14, 95 % CI = 1.03–1.26, p = 0.014; and Gln vs. Glu: OR = 1.09, 95 % CI = 1.01–1.18, p = 0.023) and Caucasian populations (homozygous model: OR = 1.33, 95 % CI = 1.11–1.59, p = 0.002; heterozygous model: OR = 1.16, 95 % CI = 1.04–1.30, p = 0.009; dominant model: OR = 1.19, 95 % CI = 1.07–1.32, p = 0.001; and Gln vs. Glu: OR = 1.15, 95 % CI = 1.06–1.25, p < 0.001). Despite some limitations, this meta-analysis established some solid statistical evidence for the association between NBS1 Glu185Gln polymorphism and increased risk for urinary system cancer, especially for bladder cancer, but more well-designed prospective studies are needed to further verify our findings.

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Authors and Affiliations

  1. State Key Laboratory of Oncology in South China, Blood Transfusion Department, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, China

    Ying Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Xi-Zhao Li & Xiao-Hui Zheng

  2. Department of Molecular Pathology, Guangzhou Kingmed Center for Clinical Laboratory, Guangzhou, Guangdong, 510330, China

    Yu-Shan Huang

  3. Department of Anesthesiology, State Key Laboratory of Oncology on Southern China, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong, 510060, China

    Wen-Qian Lin

  4. Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, China

    Qi-Wen Li

  5. Department of Nuclear Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, China

    Rong-Liang Zheng

  6. Department of Molecular Diagnostics, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, China

    Tao Tang

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  1. Ying Zhang
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Correspondence to Ying Zhang.

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Ying Zhang and Yu-Shan Huang contributed equally to this work and should be considered as co-first authors.

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Zhang, Y., Huang, YS., Lin, WQ. et al. NBS1 Glu185Gln polymorphism and susceptibility to urinary system cancer: a meta-analysis. Tumor Biol. 35, 10723–10729 (2014). https://doi.org/10.1007/s13277-014-2346-6

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  • DOI: https://doi.org/10.1007/s13277-014-2346-6

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