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X-ray repair cross-complementing group 1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population

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Tumor Biology

Abstract

There were many studies performed to assess the association between X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp polymorphism and lung cancer risk in Chinese Han population, but contradictory results were reported. To provide a comprehensive and objective assessment of the association, a meta-analysis of all eligible case–control studies was carried out. After searching the databases and reading the abstracts, 12 case–control studies on the association between XRCC1 Arg194Trp polymorphism and lung cancer risk were finally included into this meta-analysis. Those 12 studies included a total of 4,385 cases and 4,545 controls. XRCC1 Arg194Trp polymorphism was associated with increased risk of lung cancer in Chinese Han population under three main models (allele contrast model, odds ratio (OR) = 1.12, 95 % confidence interval (CI) 1.00–1.26, P = 0.049; homozygote model, OR = 1.27, 95 % CI 1.09–1.48, P = 0.003; recessive model, OR = 1.26, 95 % CI 1.09–1.46, P = 0.003). However, there was no obvious association between XRCC1 Arg194Trp polymorphism and lung cancer risk under the dominant model (OR = 1.06, 95 % CI 0.98–1.16, P = 0.146). Sensitivity analysis suggested the stability and liability of this meta-analysis. Therefore, this meta-analysis suggests that XRCC1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population.

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Acknowledgments

This study is funded by the following funds: (1) the National Natural Sciences Foundation of China (project for young scientists, no. 30800999) and (2) project supported by the Zhejiang Provincial Natural Science Foundation of China (no. Y2080374).

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None.

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Authors and Affiliations

  1. Department of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qing-Chun Road, Hangzhou, 310003, People’s Republic of China

    Tao Wu

  2. Shanghai Lung Tumor Clinic Medical Center, Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, 200030, China

    Yun-hua Xu

  3. Ningbo Institute of Medical Sciences, Ningbo, 315020, Zhejiang Province, China

    Xiao-lei Ye

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  1. Tao Wu
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  2. Yun-hua Xu
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  3. Xiao-lei Ye
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Correspondence to Tao Wu.

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Wu, T., Xu, Yh. & Ye, Xl. X-ray repair cross-complementing group 1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population. Tumor Biol. 34, 2611–2615 (2013). https://doi.org/10.1007/s13277-013-0810-3

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  • DOI: https://doi.org/10.1007/s13277-013-0810-3

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