Skip to main content

Advertisement

SpringerLink
Log in

XRCC1 genetic polymorphism acts a potential biomarker for lung cancer

  • Research Article
  • Published:
Tumor Biology

Abstract

Lung cancer is one of the most common but serious cancers in the world. Both the X-ray repair cross-complementing group 1 (XRCC1) gene and the human multidrug resistance 1 (MDR1) gene are important candidate genes influencing the susceptibility to various diseases, including lung cancer. This study aimed to assess the correlation of genetic polymorphisms in XRCC1 and MDR1 with the susceptibility to lung cancer. In this study, a total of 320 lung cancer patients and 346 cancer-free controls in Chinese population were enrolled in this study. Data about the clinical characteristics and related risk factors of lung cancer were collected by questionnaires. The single-nucleotide polymorphisms (SNPs) of XRCC1 and MDR1 genes were genotyped by created restriction site-polymerase chain reaction method. Our data showed that the risk for lung cancer increased significantly among the variant Arg194Trp (C > T, rs1799782) and Arg399Gln (G > A, rs25487) of XRCC1, but there are no significant differences in the allelic and genotypic frequencies of c.1564A > T and c.3073A > C of MDR1 between lung cancer patients and cancer-free controls. In conclusion, these preliminary results suggest that the C > T, rs1799782 and C > T, rs25487 of XRCC1 genetic variants might be used as molecular markers for detecting lung cancer susceptibility.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Cui Z, Yin Z, Li X, Wu W, Guan P, Zhou B. Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis. BMC Cancer. 2012;12(1):71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Guo Z, Zhao C, Wang Z. MicroRNAs as ideal biomarker for the diagnosis of lung cancer. Tumor Biol. 2014;35(10):10395–407.

    Article  CAS  Google Scholar 

  3. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108.

    Article  PubMed  Google Scholar 

  4. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58(1):71–96.

    Article  PubMed  Google Scholar 

  5. Ma X, Lin C, Zhen W. Cancer care in China: a general review. Lung. 2008;4(1):e39.

    Google Scholar 

  6. Chen S, Tang D, Xue K, Xu L, Ma G, Hsu Y, et al. DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population. Carcinogenesis. 2002;23(8):1321–15.

    Article  PubMed  Google Scholar 

  7. Guo S, Li X, Gao M, Li Y, Song B, Niu W. The relationship between XRCC1 and XRCC3 gene polymorphisms and lung cancer risk in northeastern Chinese. PLoS One. 2013;8(2):e56213.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Ouyang FD, Yang FL, Chen HC, Khan MA, Huang FM, Wan XX, et al. Polymorphisms of DNA repair genes XPD, XRCC1, and OGG1, and lung adenocarcinoma susceptibility in Chinese population. Tumor Biol. 2013;34(5):2843–8.

    Article  CAS  Google Scholar 

  9. Park JY, Lee SY, Jeon HS, Bae NC, Chae SC, Joo S, et al. Polymorphism of the DNA repair gene XRCC1 and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev. 2002;11(1):23–7.

    CAS  PubMed  Google Scholar 

  10. Ratnasinghe D, Yao SX, Tangrea JA. Polymorphisms of the DNA repair gene XRCC1 and lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2001;10(2):119–23.

    CAS  PubMed  Google Scholar 

  11. Zhao Y, Deng X, Wang Z, Wang Q, Liu Y. Genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 and risk of colorectal cancer in Chinese population. Asian Pac J Cancer Prev. 2012;13(2):665–9.

    Article  PubMed  Google Scholar 

  12. Huang J, Zhang J, Zhao Y, Liao B, Liu J, Li L, et al. The Arg194Trp polymorphism in the XRCC1 gene and cancer risk in Chinese Mainland population: a meta-analysis. Mol Biol Rep. 2011;38(7):4565–73.

    Article  CAS  PubMed  Google Scholar 

  13. Yin J, Vogel U, Ma Y, Qi R, Wang H. Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women. Cancer Genet Cytogenet. 2009;188(1):26–31.

    Article  CAS  PubMed  Google Scholar 

  14. Zheng H, Wang Z, Shi X, Wang Z. XRCC1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis. Lung Cancer. 2009;65(3):268–73.

    Article  PubMed  Google Scholar 

  15. Guo QX, Yang WH, Zhai JF, Han FC, Wang CY. XRCC1 codon 280 polymorphism and susceptibility to lung cancer: a meta-analysis of the literatures. Tumor Biol. 2013;34(5):2989–1994.

    Article  CAS  Google Scholar 

  16. Li Y, Huang Y, Cao YS, Zeng J, Tong WN, Xu SL, et al. Assessment of the association between XRCC1 Arg399Gln polymorphism and lung cancer in Chinese. Tumor Biol. 2013;34(6):3681–5.

    Article  CAS  Google Scholar 

  17. Bodor M, Kelley EJ, Ho RJ. Characterization of the human MDR1 gene. AAPS J. 2005;7(1):E1–5.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Borst P, Elferink RO. Mammalian ABC transporters in health and disease. Ann Rev Biochem. 2002;71(1):537–92.

    Article  CAS  PubMed  Google Scholar 

  19. Gervasini G, Carrillo JA, Garcia M, San Jose C, Cabanillas A, Benitez J. Adenosine triphosphate-binding cassette B1 (ABCB1) (multidrug resistance 1) G2677T/A gene polymorphism is associated with high risk of lung cancer. Cancer. 2006;107(12):2850–7.

    Article  CAS  PubMed  Google Scholar 

  20. Rocco A, Compare D, Liguori E, Cianflone A, Pirozzi G, Tirino V, et al. MDR1-P-glycoprotein behaves as an oncofetal protein that promotes cell survival in gastric cancer cells. Lab Investig. 2012;92(10):1407–18.

    Article  CAS  PubMed  Google Scholar 

  21. Fang Y, Zhao Q, Ma G, Han Y, Lou N. Investigation on MDR1 gene polymorphisms and its relationship with breast cancer risk factors in Chinese women. Med Oncol. 2013;30(1):375.

    Article  PubMed  Google Scholar 

  22. Hu Y, Wang J, Tao H, Wang H, Zhang X, Cheng Y, et al. Association analysis between MDR1 genetic variant and breast cancer risk factors in Chinese Han population. Med Oncol. 2013;30(1):683.

    Article  PubMed  Google Scholar 

  23. Yan Y, Liang H, Xie L, He Y, Li M, Li R, et al. Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis. Tumor Biol. 2014;35(3):2191–7.

    Article  CAS  Google Scholar 

  24. Li Y, Yan PW, Huang XE, Li CG. MDR1 gene C3435T polymorphism is associated with clinical outcomes in gastric cancer patients treated with postoperative adjuvant chemotherapy. Asian Pac J Cancer Prev. 2011;12(9):2405–9.

    PubMed  Google Scholar 

  25. Shi MM, Xiong YL, Jia XS, Li X, Zhang L, Li XL, et al. Fluorouracil selectively enriches stem-like cells in the lung adenocarcinoma cell line SPC. Tumor Biol. 2013;34(3):1503–10.

    Article  CAS  Google Scholar 

  26. Chen Q, Jiang Z, Wu L, Zhang B, Lu GH, Zhou J. Expression of alpha-tubulin and MDR1 and their correlation with the biological features of non-small cell lung carcinoma. Zhonghua Zhong Liu Za Zhi. 2010;32(4):278.

    CAS  PubMed  Google Scholar 

  27. Hu L, Wu Y, Lu GH, Chen QY, Wang YH, Zhou JY. Correlation of the expression of III β-tubulin and MDR1 protein with biological features of non-small cell lung cancer. Zhonghua Zhong Liu Za Zhi. 2010;32(10):762–6.

    CAS  PubMed  Google Scholar 

  28. Chen S, Huo X, Lin Y, Li W, Zhang B, Au WW, et al. Association of MDR1 and ERCC1 polymorphisms with response and toxicity to cisplatin-based chemotherapy in non-small-cell lung cancer patients. Int J Hyg Environ Health. 2010;213(1):140–5.

    Article  CAS  PubMed  Google Scholar 

  29. Dogu GG, Kargi A, Turgut S, Ayada C, Taskoylu BY, Demiray G, et al. MDR1 single nucleotide polymorphism C3435T in Turkish patients with non-small-cell lung cancer. Gene. 2012;506(2):404–7.

    Article  CAS  PubMed  Google Scholar 

  30. Melguizo C, Prados J, Luque R, Oritz R, Caba O, Alvare PJ, et al. Modulation of MDR1 and MRP3 gene expression in lung cancer cells after paclitaxel and carboplatin exposure. Int J Mol Sci. 2012;13(12):16624–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Takakuwa O, Oguri T, Ozasa H, Uemura T, Kasai D, Miyazaki M, et al. Over-expression of MDR1 in amrubicinol-resistant lung cancer cells. Cancer Chemother Pharmacol. 2011;68(3):669–76.

    Article  CAS  PubMed  Google Scholar 

  32. Vinolas N, Provencio M, Reguart N, Carenal F, Alberola V, Sanchez-Torres JM, et al. Single nucleotide polymorphisms in MDR1 gen correlates with outcome in advanced non-small-cell lung cancer patients treated with cisplatin plus vinorelbine. Lung Cancer. 2011;71(2):191–8.

    Article  CAS  PubMed  Google Scholar 

  33. Yan P, Huang X, Yan F, Xu L, Jiang Y. Influence of MDR1 gene codon 3435 polymorphisms on outcome of platinum-based chemotherapy for advanced non small cell lung cancer. Asian Pac J Cancer Prev. 2011;12(9):2291–4.

    PubMed  Google Scholar 

  34. Zhao L, Li K, Li W, Yang Z. Association between the C3435T polymorphism of ABCB1/MDR1 gene (rs1045642) and colorectal cancer susceptibility. Tumor Biol. 2013;34(3):1949–57.

    Article  CAS  Google Scholar 

Download references

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Department of Oncology, Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road Avenue, Changsha, Hunan, 410011, China

    Dao-Qi Zhu, Chun-Hong Hu & Ping Liu

  2. Department of Oncology, No. 163 Central Hospital, Chinese People’s Liberation Army, Changsha, Hunan, 410003, China

    Dao-Qi Zhu, Jia-Li Su & Guang-Hua Zhou

  3. Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China

    Qiong Zou

Authors
  1. Dao-Qi Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qiong Zou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chun-Hong Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jia-Li Su
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Guang-Hua Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ping Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chun-Hong Hu.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhu, DQ., Zou, Q., Hu, CH. et al. XRCC1 genetic polymorphism acts a potential biomarker for lung cancer. Tumor Biol. 36, 3745–3750 (2015). https://doi.org/10.1007/s13277-014-3014-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-014-3014-6

Keywords

Search

Navigation