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Decursin and decursinol angelate affect spermatogenesis in the adult rat at oral administration

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Abstract

The aim of this study was to investigate the positive effects of decursin and decursinol angelate (D/DA) on the reproductive system of male rats as well as to examine whether D/DA is able to ameliorate the effects of bisphenol A (BPA). Adult rats were divided into the following four groups: (1) control, (2) BPA, (3) D/DA, and (4) BPA+D/DA. Organ weight ratio of vital organs decreased in the kidney (9.5%) and increased in the prostate (24.07%) and epididymis (22.14%) in the BPA+D/DA group compared to the values in the BPA group. A significant decrease (P<0.05) in sperm count was found in the BPA+D/DA (18.91%) and BPA(54.05%) groups compared to the count in the control group. In only D/DA (20.14%) group, sperm count was significantly increased. D/DA ameliorated the histopathological changes induced by BPA in the testis, consistent with these data. D/DA was also identified as promoting the activities of antioxidant enzymes such as catalase (CAT) and glutathione peroxidase (GPx), the levels of which were significantly increased compared to the corresponding levels in the BPA group. Fas/FasL (FAS) and caspase-3 (CAP) levels were significantly decreased in rats. The results suggest that D/DA reduces apoptosis of Leydig and germ cells in the mouse testis through the Fas-signaling pathway.

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Authors and Affiliations

  1. Department of Pharmacy, Kyungsung University, Busan, Korea

    Kang Min Kim, Ju Lee Seo & Jae Seon Kang

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  1. Kang Min Kim
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  2. Ju Lee Seo
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  3. Jae Seon Kang
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Correspondence to Jae Seon Kang.

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Kim, K.M., Seo, J.L. & Kang, J.S. Decursin and decursinol angelate affect spermatogenesis in the adult rat at oral administration. Mol. Cell. Toxicol. 10, 83–89 (2014). https://doi.org/10.1007/s13273-014-0010-2

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  • DOI: https://doi.org/10.1007/s13273-014-0010-2

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