Skip to main content
SpringerLink
Log in

Alendronate-modified hydroxyapatite nanoparticles for bone-specific dual delivery of drug and bone mineral

  • Articles
  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

Alendronate (Alen)-modified hydroxyapatite (HAp) nanoparticles with multilayers of poly(allylamine) (PAA) and alginate (ALG) were fabricated for bone-specific dual delivery of drug and mineral. Negatively charged HAp nanoparticles were coated with three layers of PAA and ALG using a layer-by-layer (LbL) method and then conjugated with Alen at the outmost layer of the LbL-coated HAp nanoparticles via carbodiimide chemistry. Alen-modified HAp nanoparticles had a spherical morphology and an average size of 61.5 nm. The superior adsorption property of the Alen-modified HAp nanoparticles was quantitatively confirmed using tricalcium phosphate disks as a bone model, compared to HAp nanoparticles. Cell culture assays revealed a higher proliferation rate and alkaline phosphatase activity of osteoblasts treated with the Alen-modified HAp nanoparticles.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. Gass and B. Dawson-Hughes, Am. J. Med., 119, S3 (2006).

    Article  Google Scholar 

  2. G. I. Im, S. A. Qureshi, J. Kenney, H. E. Rubash, and A. S. Shanbhag, Biomaterials, 25, 4105 (2004).

    Article  CAS  Google Scholar 

  3. S. E. Papapoulos, Ann. N. Y. Acad. Sci., 1218, 15 (2011).

    Article  CAS  Google Scholar 

  4. S. L. Silverman, Ann. N. Y. Acad. Sci., 1218, 33 (2011).

    Article  CAS  Google Scholar 

  5. K. Rupel, G. Perinetti, L. Contardo, G. Ottaviani, M. Gobbo, S. De Iudicibus, R. Di Lenard, and M. Biasotto, J. Mol. Biomarker. Diagn., 5, 1 (2014).

    Google Scholar 

  6. M. D. Francis, R. G. Russell, and H. Fleisch, Science, 165, 1264 (1969).

    Article  CAS  Google Scholar 

  7. C. T. Leu, E. Luegmayr, L. P. Freedman, G. A. Rodan, and A. A. Reszka, Bone, 38, 628 (2006).

    Article  CAS  Google Scholar 

  8. H. Fleisch, R. Graham, G. Russell, and M. D. Francis, Science, 165, 1262 (1969).

    Article  CAS  Google Scholar 

  9. H. Fleisch, Endocr. Rev., 19, 80 (1998).

    Article  CAS  Google Scholar 

  10. V. Lezcano, T. Bellido, L. I. Plotkin, R. Boland, and S. Morelli, Arch. Biochem. Biophys., 518, 95 (2012).

    Article  CAS  Google Scholar 

  11. K. Komatsu, A. Shimada, T. Shibata, S. Wada, H. Ideno, K. Nakashima, N. Amizuka, M. Noda, and A. Nifuji, J. Endocrinol., 219, 145 (2013).

    Article  CAS  Google Scholar 

  12. S. W. Choi and J. H. Kim, J. Control. Release, 122, 24 (2007).

    Article  CAS  Google Scholar 

  13. D. Wang, S. C. Miller, P. Kopecková, and J. Kopecek, Adv. Drug Deliv. Rev., 57, 1049 (2005).

    Article  CAS  Google Scholar 

  14. D. Wang, M. Sima, R. L. Mosley, J. P. Davda, N. Tietze, S. C. Miller, P. R. Gwilt, P. Kopeckova, and J. Kopecek, Mol. Pharm., 3, 717 (2006).

    Article  CAS  Google Scholar 

  15. H. Pan, P. Kopecková, J. Liu, D. Wang, S. C. Miller, and J. Kopecek, Pharm. Res., 24, 2270 (2007).

    Article  CAS  Google Scholar 

  16. M. Xie, M. Ø. Olderøy, Z. Zhang, J. P. Andreassen B. L. Strandd, and P. Sikorski, RSC Adv., 2, 1457 (2012).

    Article  CAS  Google Scholar 

  17. S. D. Jiang, Q. Z. Yao, G. T. Zhou, and S. Q. Fu, J. Phys. Chem., 116, 4484 (2012).

    Article  CAS  Google Scholar 

  18. J. Han, Z. Y. Zhou, R. X. Yin, D. Z. Yang, and J. Nie, Int. J. Biol. Macromol., 46, 199 (2010).

    Article  CAS  Google Scholar 

  19. K. Watanabea, Y. Nishiob, R. Makiurac, A. Nakahirab, and C. Kojimac, Int. J. Pharm., 446, 81 (2013).

    Article  Google Scholar 

  20. Y. Mizushima, T. Ikoma, J. Tanaka, K. Hoshi, T. Ishihara, Y. Ogawa, and A. Ueno, J. Control. Release, 110, 260 (2006).

    Article  CAS  Google Scholar 

  21. Y.-H. Yang, C.-H. Liu, Y.-H. Liang, F.-H. Lin, and K. C.-W. Wu, J. Mater. Chem. B, 1, 2447 (2013).

    Article  CAS  Google Scholar 

  22. Y.-H. Liang, C.-H. Liu, S.-H. Liao, Y.-Y. Lin, H.-W. Tang, S.-Y. Liu, I-R. Lai, and K. C.-W. Wu, ACS Appl. Mater. Interfaces, 4, 6720 (2012).

    Article  CAS  Google Scholar 

  23. K. S. Yadav, K. Chuttani, A. K. Mishra, and K. K. Sawant, PDA J. Pharm. Sci. Technol., 65, 131 (2011).

    CAS  Google Scholar 

  24. M. Tang, P. J. Russell, and A. Khatri, Discov. Med., 7, 68 (2009).

    Google Scholar 

  25. D. D. Deligianni, N. D. Katsala, P. G. Koutsoukos, and Y. F. Missirlis, Biomaterials, 22, 87 (2000).

    Article  Google Scholar 

  26. M. Lampin, R. Warocquier-Clérout, C. Legris, M. Degrange, and M. F. Sigot-Luizard, J. Biomed. Mater. Res., 36, 99 (1997).

    Article  CAS  Google Scholar 

  27. J. Lincks, B. D. Boyan, C. R. Blanchard, C. H. Lohmann, Y. Liu, D. L. Cochran, D.D. Dean, and Z. Schwartz, Biomaterials, 19, 2219 (1998).

    Article  CAS  Google Scholar 

  28. R. A. Gittens, T. McLachlan, R. Olivares-Navarrete, Y. Cai, S. Berner, R. Tannenbaum, Z. Schwartz, K. H. Sandhage, and B. D. Boyan, Biomaterials, 32, 3395 (2011).

    Article  CAS  Google Scholar 

  29. J. Sun, F. Song, W. Zhang, B. E. Sexton, and L. J. Windsor, Arch. Oral Biol., 57, 728 (2012).

    Article  CAS  Google Scholar 

  30. J. E. Gough, I. Notingher, and L. L. Hench, J. Biomed. Mater. Res. A, 68, 640 (2004).

    Article  CAS  Google Scholar 

  31. S. Puckett, R. Pareta, and T. J. Webster, Int. J. Nanomedicine, 3, 229 (2008).

    CAS  Google Scholar 

  32. B. Groessner-Schreiber and R. S. Tuan, J. Cell Sci., 101, 209 (1992).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi, 14662, Korea

    Seok-Joon Hwang, Ji-Seon Lee, Tae-Kyung Ryu, Rae-Hyung Kang, Ki-Young Jeong, Dae-Ryong Jun & Sung-Wook Choi

  2. Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea

    Jung-Min Koh

  3. Department of Orthopaedic Surgery and Rare Diseases Institute, Korea University, Medical College, Guro Hospital, Guro-dong, Guro-gu, Seoul, 08308, Korea

    Sung-Eun Kim

Authors
  1. Seok-Joon Hwang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ji-Seon Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tae-Kyung Ryu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Rae-Hyung Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ki-Young Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Dae-Ryong Jun
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jung-Min Koh
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sung-Eun Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Sung-Wook Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Sung-Eun Kim or Sung-Wook Choi.

Additional information

These authors equally contributed to this work.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hwang, SJ., Lee, JS., Ryu, TK. et al. Alendronate-modified hydroxyapatite nanoparticles for bone-specific dual delivery of drug and bone mineral. Macromol. Res. 24, 623–628 (2016). https://doi.org/10.1007/s13233-016-4094-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13233-016-4094-5

Keywords

Search

Navigation