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Exploration of nutritional, antioxidative, antibacterial and anticancer status of Russula alatoreticula: towards valorization of a traditionally preferred unique myco-food

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Abstract

Healthy food trend is becoming popular these days fueling search for ingredients empowered by pharma-nutritional benefits. In contrast, numerous wild-growing mushrooms are traditionally cherished as health promoting gastronomies in India; although credibility of their effects has so far been limited. Hence the present study aimed to unveil a unique tribal cuisine, Russula alatoreticula, with nutritional, chemical and pharmacological relevance. The outcome demonstrated an excellent alimentary composition with carbohydrate and protein as prominent macronutrients in contrast to fat providing oleic acid (36.66%), linoleic acid (16.84%), palmitic acid (16.01%) and stearic acid (15.31%) indicative of profitable nutritive account. Conversely, ethanolic fraction enriched with phenolics (pyrogallol > cinnamic acid) presented effective antioxidant property in terms of radical scavenging, Fe2+ chelating and reducing power with EC50 ranging from 785 to 2500 μg/ml. Remarkable antibacterial activity was also noted against the tested microorganisms (MIC of 72.5–1560 μg/ml) preferentially targeting Gram-positive one. Besides treatment of the preparation rendered Hep3B proliferation as evident by phenotypic changes, cell cycle interference, reactive oxygen species generation, mitochondrial membrane potential reduction, DNA fragmentation, change in Bax/Bcl2 ratio and activation of caspase9 signifying induction of intrinsic mitochondrial pathway. Thus the study represents R. alatoreticula as a value-added bio-resource that could be featured in food and pharmaceutical industries for betterment of humankind.

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Acknowledgements

Authors S.K. and K.A. would like to acknowledge the facilities provided by Department of Botany (UGC-CAS Phase VI, VII), University of Calcutta and DST-FIST for instrumental support.

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Authors and Affiliations

  1. Molecular and Applied Mycology and Plant Pathology Laboratory, Centre of Advanced Study, Department of Botany, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, West Bengal, 700019, India

    Somanjana Khatua & Krishnendu Acharya

  2. Department of Chemical Technology, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata, West Bengal, 700009, India

    Surashree Sen Gupta & Mahua Ghosh

  3. Institute of Agricultural Science, University of Calcutta, 51/2 Hazra Road, Kolkata, West Bengal, 700019, India

    Sudipta Tripathi

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  1. Somanjana Khatua
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  2. Surashree Sen Gupta
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  3. Mahua Ghosh
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  4. Sudipta Tripathi
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  5. Krishnendu Acharya
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Correspondence to Krishnendu Acharya.

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Khatua, S., Sen Gupta, S., Ghosh, M. et al. Exploration of nutritional, antioxidative, antibacterial and anticancer status of Russula alatoreticula: towards valorization of a traditionally preferred unique myco-food. J Food Sci Technol 58, 2133–2147 (2021). https://doi.org/10.1007/s13197-020-04723-9

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  • DOI: https://doi.org/10.1007/s13197-020-04723-9

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