Skip to main content
SpringerLink
Log in

Biological activities of fructooligosaccharide (FOS)-containing Coix lachryma-jobi Linn. extract

  • Original Article
  • Published:
Journal of Food Science and Technology Aims and scope Submit manuscript

Abstract

Fructooligosaccharide (FOS), a prebiotic was extracted from the grain of Coix lachryma-jobi Linn. (Job’s tears) by hot water extraction at 60 °C for 1 h. The resulting dried powder extract was assayed for FOS content of 1-kestose (GF2), nystose (GF3) and 1-β-D-fructofuranosylnystose (GF4) using HPLC equipped with RI detector. Total FOS content of the extract was 24.98 ± 7.48% (g/100 g crude extract). The biological activity including antioxidant and cytotoxicity of the FOS-containing extract was determined. The antioxidant activity by DPPH free radical scavenging of FOS-containing extract was comparable to vitamin C (0.97 fold of vitamin C) with a slight lipid peroxidation inhibition activity. The extract exhibited no cytotoxic effect on normal human skin fibroblast. These results have confirmed not only the source of FOS from Job’s tears extract but also its potential application as antioxidant in food or cosmetic products.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Brand-Williams W, Cuvelier ME, Berset C (1995) Use of a free radical method to evaluate antioxidant activity. J Food Sci Technol 28(1):25–30

    CAS  Google Scholar 

  • Bunce TJ, Howard MD, Allee GL, Pace LW (1995) Protective effects of fructooligosaccharide (FOS) in prevention of mortality and morbidity from infectious E. coli K:88 challenge. J Anim Sci 73(suppl 1):69 (Abstr.)

    Google Scholar 

  • Choi KH, Namhrng H, Paid IK (1994) Effects of dietary fructo-oligosaccharide on the suppression of intestinal colonization of Salmonella typhimurium in broiler chickens. Korean J Anim Sci 36:271–284

    CAS  Google Scholar 

  • Dechsakulthorn F, Hayes A, Bakand S, Joeng L, Winder C (2007) In vitro cytotoxicity assessment of selected nanoparticles using human skin fibroblasts. Proc 6th World Congress on Alternatives & Animal Use in the Life Sciences 14:21–25

    Google Scholar 

  • Decker EA, Welch B (1990) Role of ferritin as a lipid oxidation catalyst in muscle food. J Agr Food Chem 38:674–677

    Article  CAS  Google Scholar 

  • Fukata T, Sasai K, Miyamoto T, Baba E (1999) Inhibitory effects of competitive exclusion and fructooligosaccharide, singly and in combination, on Salmonella colonization of chicks. J Food Prot 62:229–233

    CAS  Google Scholar 

  • Hidaka H, Eida T, Hanaya T (1986) Livestock feed containing inulo-oligosaccharides and breeding of livestock by using the same. European Patent No. 017026A2

  • Huebner J, Wehling RL, Parkhurst A, Hutkins RW (2008) Effect of processing conditions on the prebiotic activity of commercial prebiotics. Int Dairy J 18:287–293

    Article  CAS  Google Scholar 

  • Iordãchescu D, Dinu D, Bonoiu A, Bucatã G, Ciubãr R, Homeghiu C, Iancu C, Stan C, Nae S (2002) Time and dose-response study of the effects of vanadate on human skin fibroblasts. Romanian J Biophys 12:69–76

    Google Scholar 

  • Jiang JW, Xiao QX (1986) Handbook of active ingredients from medicinal plants. People’s Health Press, Beijing

    Google Scholar 

  • Jideani IA, Jideani VA (2011) Developments on the cereal grains Digitaria exilis (acha) and Digitaria iburua (iburu). J Food Sci Technol 48:251–259

    Article  CAS  Google Scholar 

  • Kuo CC, Shih MC, Kuo YH, Chiang W (2001) Antagonism of free-radical-induced damage of adlay seed and its antiproliferative effect in human histolytic lymphoma U237 monocytic cells. J Agric Food Chem 49:1564–1570

    Article  CAS  Google Scholar 

  • Kwak CS, Lim SJ, Kim SA, Park SC, Lee MS (2004) Antioxidative and antimutagenic effects of Korean Buckwheat, Sorghum, Millet and Job’s tears. J Korean Soc Food Sci Nutr 33(6):921–929

    Article  CAS  Google Scholar 

  • Lakkham K, Wangsomnuk P, Aromdee C (2009) Identification and quality of four varieties of adlay. Songklanakarin J Sci Technol 31(4):425–431

    Google Scholar 

  • Lee JK, Kim DB, Kim JI, Kim PY (2000) In vitro cytotoxicity tests on cultured human skin fibroblasts to predict skin irritation potential of surfactants. Toxicol in Vitro 14(4):345–349

    Article  CAS  Google Scholar 

  • Li DP (2006) Research advance on ethenopharmacology, pharmacodynamics, pharmacokinetics and clinical therapeutics of Coix seed and its preparation, Kanglaite injection. Asian J Pharmacodyn Pharmacokinet 6(2):83–102

    Google Scholar 

  • Manosroi A, Ruksiriwanich W, Abe M, Sakai H, Manosroi W, Manosroi J (2010) Biological activities of the rice bran extract and physical characteristics of its entrapment in niosomes by supercritical carbon dioxide fluid. J Supercritical Fluids 54:137–144

    Article  CAS  Google Scholar 

  • Manosroi A, Khositsuntiwong N, Komno C, Manosroi W, Werner RG, Manosroi J (2011) Chemical stability and cytotoxicity of human insulin loaded in cationic DPPC/CTA/DDAB liposomes. J Biomed Nanotechnol 7(2):308–316

    Article  CAS  Google Scholar 

  • Mesa MD, Silván JM, Olza J, Gil Á, Castillo MD (2008) Antioxidant properties of soy protein-fructooligosaccharide glycation systems and its hydrolysates. Food Res Int 41:606–615

    Article  CAS  Google Scholar 

  • Osawa T, Namiki M (1981) A novel type of antioxidant isolated from leaf wax of Eucalyptus leaves. Agr Biol Chem 45:735–739

    Article  CAS  Google Scholar 

  • Roberfroid MB, Vanloo JAE, Gibson GR (1998) The bifidogenic nature of chicory inulin and its hydrolysis products. J Nutr 128:11–19

    CAS  Google Scholar 

  • Sun Q, Shen H, Luo Y (2011) Antioxidant activity of hydrolysates and peptide fractions derived from porcine hemoglobin. J Food Sci Technol 48(1):53–60

    Article  CAS  Google Scholar 

  • Tachibana Y, Kikuzaki H, Hj-Lajis N, Nakatani N (2001) Antioxidant activity of carbazoles from Murraya koenigii leaves. J Agr Food Chem 49:5589–5594

    Article  CAS  Google Scholar 

  • Tsai P, Hsieh YY, Huang TC (2004) Effect of sugar on anthocyanin degradation and water mobility in a roselle anthocyanin model system using 180 NMR. J Agr Food Chem 52:3097–3099

    Article  CAS  Google Scholar 

  • Tseng YH, Yang JH, Chang HL, Lee YL, Mau JL (2006) Antioxidant properties of methanolic extracts from monascal adlay. Food Chem 97:375–381

    Article  CAS  Google Scholar 

  • Xu ZR, Hu CH, Wang MQ (2002) Effects of fructooligosaccharide on conversion of L-tryptophan to skatole and indole by mixed populations of pig fecal bacteria. J Gen Appl Microbiol 48:83–89

    Article  CAS  Google Scholar 

  • Xu ZR, Hu CH, Zhan XA, Wang MQ (2003) Effects of dietary fructooligosaccharide on digestive enzyme activities, intestinal microflora and morphology of male broilers. Poultry Sci 82:1030–1036

    CAS  Google Scholar 

Download references

Acknowledgement

This work was supported by the Thailand Research Fund (TRF) and Natural Product Research and Development Center (NPRDC), Science and Technology Research Institute (STRI), Chiang Mai University (Chiang Mai, Thailand).

Author information

Authors and Affiliations

  1. Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand

    Jiradej Manosroi, Narinthorn Khositsuntiwong & Aranya Manosroi

  2. Natural Products Research and Development Center (NPRDC), Science and Technology Research Institute (STRI), Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand

    Jiradej Manosroi & Aranya Manosroi

Authors
  1. Jiradej Manosroi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Narinthorn Khositsuntiwong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aranya Manosroi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jiradej Manosroi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Manosroi, J., Khositsuntiwong, N. & Manosroi, A. Biological activities of fructooligosaccharide (FOS)-containing Coix lachryma-jobi Linn. extract. J Food Sci Technol 51, 341–346 (2014). https://doi.org/10.1007/s13197-011-0498-6

Download citation

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13197-011-0498-6

Keywords

Search

Navigation