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Bone Marrow Chimeras in the Study of Experimental Stroke

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Abstract

Inflammation is known to contribute to stroke evolution, and poststroke immune responses have been documented to emanate from the brain via microglia. However, circulating immune cells are increasingly recognized to play a significant role as well. Recent work has demonstrated the importance of the peripheral circulation and stroke pathogenesis. Understanding how the peripheral circulation contributes to ischemic brain injury may reveal important therapeutic targets and strategies. The use of bone marrow chimeras can be a useful tool in understanding the relative contributions of brain resident and peripheral inflammatory responses.

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Acknowledgments

This work was supported by NIH grants R01 NS40516 (MAY), P50 NS014543 (MAY) and a VA Merit Award (MAY). Grants to MAY were administered by the Northern California Institute for Research and Education and supported by resources of the Veterans Affairs Medical Center, San Francisco, California.

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Authors and Affiliations

  1. Department of Neurology, University of California, San Francisco, San Francisco, CA, USA

    Xian Nan Tang, Zhen Zheng & Midori A. Yenari

  2. Neurology (127), San Francisco Veterans Affairs Medical Center, 4150 Clement St., San Francisco, CA, 94121, USA

    Zhen Zheng & Midori A. Yenari

  3. Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA

    Xian Nan Tang

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  1. Xian Nan Tang
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  2. Zhen Zheng
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  3. Midori A. Yenari
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Correspondence to Midori A. Yenari.

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Tang, X.N., Zheng, Z. & Yenari, M.A. Bone Marrow Chimeras in the Study of Experimental Stroke. Transl. Stroke Res. 3, 341–347 (2012). https://doi.org/10.1007/s12975-012-0169-6

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  • DOI: https://doi.org/10.1007/s12975-012-0169-6

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