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Inflammatory Responses After Ischemic Stroke

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Abstract

Ischemic stroke generates an immune response that contributes to neuronal loss as well as tissue repair. This is a complex process involving a range of cell types and effector molecules and impacts tissues outside of the CNS. Recent reviews address specific aspects of this response, but several years have passed and important advances have been made since a high-level review has summarized the overall state of the field. The present review examines the initiation of the inflammatory response after ischemic stroke, the complex impacts of leukocytes on patient outcome, and the potential of basic science discoveries to impact the development of therapeutics. The information summarized here is derived from broad PubMed searches and aims to reflect recent research advances in an unbiased manner. We highlight valuable recent discoveries and identify gaps in knowledge that have the potential to advance our understanding of this disease and therapies to improve patient outcomes.

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  1. Jonathan Howard DeLong and Sarah Naomi Ohashi contributed equally to this work

Authors and Affiliations

  1. Departments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, USA

    Jonathan Howard DeLong, Sarah Naomi Ohashi, Kevin Charles O’Connor & Lauren Hachmann Sansing

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  1. Jonathan Howard DeLong
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  2. Sarah Naomi Ohashi
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  3. Kevin Charles O’Connor
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  4. Lauren Hachmann Sansing
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Correspondence to Lauren Hachmann Sansing.

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This article is a contribution to the special issue on: Neuroimmune Interactions in Health and Disease - Guest Editors: David Hafler & Lauren Sansing

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DeLong, J.H., Ohashi, S.N., O’Connor, K.C. et al. Inflammatory Responses After Ischemic Stroke. Semin Immunopathol 44, 625–648 (2022). https://doi.org/10.1007/s00281-022-00943-7

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  • DOI: https://doi.org/10.1007/s00281-022-00943-7

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