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Relation of Poor Nutritional Status to Mild Cognitive Impairment in Patients with Coronary Artery Disease

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The journal of nutrition, health & aging

Abstract

Objectives

Nutritional status affects cerebral circulation and cognitive function. More attention needs to be paid to nutritional status in coronary artery disease (CAD) patients, yet the relation between nutritional status or dietary intake (DI) and cognitive function or mild cognitive impairment (MCI) in CAD patients remain unclear. Thus, we examined the following relations: 1) that between nutritional status and cognitive function, and MCI and 2) that between DI and cognitive function, and MCI.

Design, Setting, and Participants

We conducted a cross-sectional study of 208 patients with CAD but without dementia.

Measurements

MCI was estimated with the Japanese version of the Montreal Cognitive Assessment (MoCA-J). Nutritional status was assessed by the Geriatric Nutritional Risk Index (GNRI), and DI was assessed by total energy intake per day. We investigated the relation between nutritional status or DI and cognitive function by Pearson correlation analysis, and that between nutritional status or DI and MCI by multivariable logistic regression analysis.

Results

The GNRI and DI were positively associated with the MoCA-J score (r = 0.23, p < 0.001, and r = 0.24, p < 0.001, respectively), and both were independently associated with MCI in the multivariable logistic regression analysis (odds ratio, 0.96; p = 0.045, and odds ratio, 0.998; p = 0.020, respectively).

Conclusions

Poor nutritional status and low DI were found to be significantly associated with cognitive function and MCI in CAD patients. Our findings regarding nutritional status and DI might be useful for clinicians to prevent or intervene in the early cognitive decline of inpatients with CAD.

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Acknowledgments

This work was supported by JSPS KAKENHI Grant Numbers JP17K01S00, JP19K10921. All authors declare no conflicts of interest in relation to the work reported in this manuscript. We thank the staff members of the Sakakibara Heart Institute of Okayama and Kobe University who collaborated in this study. This study was also benefitted by the support and encouragement of Dr. Masashi Kanai, Ms. Asami Ogura, Mr. Ikko Kubo, Mr. Hiroto Ogi and Dr. Shinichi Shimada, Department of Public Health, Graduate School of Health Sciences, Kobe University, and Dr. Koichi Naito, Department of Physical Therapy, Hakuho College. We also thank Dr. Minato Nakazawa, Department of Public Health, Graduate School of Health Sciences, Kobe University, for statistical support in the present study.

Author information

Authors and Affiliations

  1. Department of Rehabilitation, Sakakibara Heart Institute of Okayama, Kita-ku, Okayama, Japan

    K. Ishihara

  2. Department of Public Health, Graduate School of Health Sciences, Kobe University, 10-2 Tomogaoka 7-chome, Suma-ku, Kobe, 654-0142, Japan

    K. Ishihara, Kazuhiro P. Izawa, M. Kitamura, M. Ogawa, T. Shimogai & Y. Kanejima

  3. Cardiovascular stroke Renal Project (CRP), Fukuokawajiro Rehabilitation College, Higashi-ku, Fukuoka, Japan

    K. Ishihara, Kazuhiro P. Izawa, M. Kitamura, M. Ogawa, T. Shimogai & Y. Kanejima

  4. Department of Physical Therapy, Fukuokawajiro Rehabilitation College, Higashi-ku, Fukuoka, Japan

    M. Kitamura

  5. Department of Rehabilitation Medicine, Kobe University Hospital, Chuo-ku, Kobe, Japan

    M. Ogawa

  6. Department of Rehabilitation, Kobe City General Hospital, Chuo-ku, Kobe, Japan

    T. Shimogai & Y. Kanejima

  7. Department of Physical Therapy, Faculty of Health Sciences, Juntendo University, Bunkyo-ku, Tokyo, Japan

    T. Morisawa

  8. Department of Diabetes, Sakakibara Heart Institute of Okayama, Kitaku, Okayama, Japan

    I. Shimizu

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  1. K. Ishihara
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  2. Kazuhiro P. Izawa
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  3. M. Kitamura
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Corresponding author

Correspondence to Kazuhiro P. Izawa.

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Conflicts of interest: The authors declare that they have no conflict of interest.

Ethical standards: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards.

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Ishihara, K., Izawa, K.P., Kitamura, M. et al. Relation of Poor Nutritional Status to Mild Cognitive Impairment in Patients with Coronary Artery Disease. J Nutr Health Aging 24, 1080–1086 (2020). https://doi.org/10.1007/s12603-020-1428-y

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  • DOI: https://doi.org/10.1007/s12603-020-1428-y

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