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Association between both total baseline urinary and dietary polyphenols and substantial physical performance decline risk in older adults: A 9-year follow-up of the InCHIANTI study

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The journal of nutrition, health & aging

Abstract

Importance

The decline in physical performance that occurs in many older subjects is a strong predictor of falls, hospitalization, institutionalization and mortality. Polyphenols are bioactive compounds that may play a preventive role against physical performance decline due to their antioxidant and anti-inflammatory properties.

Objective

To investigate the association between total urinary polyphenols (TUP) and total dietary polyphenols (TDP) and substantial physical performance decline over a nine-year period among older subjects.

Methods

This longitudinal study included 368 participants aged 65 years or older from the InCHIANTI (Invecchiare in Chianti) study, an Italian population-based cohort. TUP and TDP concentrations were assessed at baseline using the Folin-Ciocalteau (F-C) assay and a validated food frequency questionnaire, respectively. Physical performance was objectively measured at baseline and at nine-year follow-up using the Short Physical Performance Battery (SPPB). A substantial decline in physical performance was considered as a decrease of three or more points in the SPPB score.

Results

At the nine-year follow-up assessment, 71 participants had suffered a substantial decline in physical performance. In the fully adjusted logistic regression model, participants in the highest TUP tertile had a lower risk of substantial decline in physical performance than those in the lowest tertile (OR, 0.40; 95% CI, 0.17–0.93; P trend=0.033). However, no significant association between TDP intake and physical performance decline was observed.

Conclusion

This study shows that high TUP concentrations, a biomarker of polyphenol-rich exposure, were associated with lower risk of substantial decline in physical performance in community-dwelling older subjects over a nine-year period. These results suggest that a polyphenol-rich diet may play a role in protecting against physical performance decline in older people.

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Abbreviations

TUP:

total urinary polyphenols

TDP:

total dietary polyphenols

InCHIANTI:

Invecchiare in Chianti

F-C:

Folin-Ciocalteau

SPPB:

Short Physical Performance Battery

OR:

odds ratio

CI:

confidence interval

GAE:

gallic acid equivalents

BMI:

body mass index

MMSE:

Mini-Mental State Examination

CES-D:

Center for Epidemiologic Studies Depression Scale

ADL:

activities of daily living

IADL:

instrumental activities of daily living

SD:

standard deviation

IQR:

interquartile range

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Author information

Authors and Affiliations

  1. Biomarkers and Nutrimetabolomics Laboratory, Nutrition and Food Science Department, XaRTA, INSA, Campus Torribera, Pharmacy and Food Sciences Faculty, University of Barcelona, Barcelona, Spain

    M. Rabassa, C. Andres-Lacueva & M. Urpi-Sarda

  2. Biomarkers group (BMA), Nutrition and Metabolism Section (NME), International Agency for Research on Cancer (IARC), Lyon, France

    R. Zamora-Ros

  3. Geriatric Unit, Azienda Sanitaria Firenze, Florence, Italy

    S. Bandinelli

  4. Clinical Research Branch, National Institute on Aging, Baltimore, MD, United States

    L. Ferrucci

  5. Geriatrics and Geriatric Emergency Care, Italian National Research Centre on Aging (IRCCS -INRCA), Ancona, Italy

    A. Cherubini

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  1. M. Rabassa
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  2. R. Zamora-Ros
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  3. C. Andres-Lacueva
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  4. M. Urpi-Sarda
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  5. S. Bandinelli
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  6. L. Ferrucci
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  7. A. Cherubini
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Correspondence to C. Andres-Lacueva.

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Rabassa, M., Zamora-Ros, R., Andres-Lacueva, C. et al. Association between both total baseline urinary and dietary polyphenols and substantial physical performance decline risk in older adults: A 9-year follow-up of the InCHIANTI study. J Nutr Health Aging 20, 478–484 (2016). https://doi.org/10.1007/s12603-015-0600-2

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  • DOI: https://doi.org/10.1007/s12603-015-0600-2

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