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Changes in blood oxidative and antioxidant parameters in a group of Chinese patients with age-related macular degeneration

  • JNHA: Nutrition
  • Published:
The journal of nutrition, health & aging

Abstract

Objective

To measure the oxidative and antioxidant biochemical parameters in the serum of Chinese patients with age-related macular degeneration (AMD) and in a similar age control group from the same area.

Design

A case-control study.

Participants

56 AMD patients (21 early dry, 13 geographic atrophy and 22 wet form) and 34 normal subjects, similar for age and sex were studied.

Measurements

Both groups completed a questionnaire about demographic characters and dieatry habit, and the levels of serum lipid peroxidation (malondialdehyde, MDA) and antioxidants parameters (vitamin C and E, the activities of superoxide dismutase-SOD, total antioxidant capacity — TAC) were determined.

Results

There was a significantly higher frequency of daily intake of fruit and legumes in controls than in AMD patients. There was a significantly increased serum MDA levels and SOD activities, and significantly decreased serum vitamin C and total antioxidant capacity in AMD patients as compared to controls. The intensity of lipid peroxidation was higher with the progression of AMD. There was not difference in serum vitamin E levels between AMD patients and controls.

Conclusion

Oxido-reduction disturbance may be involved in the pathogenesis of AMD. There is a significantly decreased antioxidant capacity in AMD patients.

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Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, 110001, China

    Xueli Shen

  2. Department of Nutrition and Food hygiene, School of Public Health, China Medical University, Shenyang, China

    L. H. Jia, X. Y. Pan, H. M. Yang & L. Liu

  3. Shenyang AIER Ophthalmology Hospital, Shenyang, China

    P. Zhao & R. Fan

Authors
  1. Xueli Shen
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  2. L. H. Jia
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  3. P. Zhao
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  4. R. Fan
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  5. X. Y. Pan
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  6. H. M. Yang
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  7. L. Liu
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Correspondence to Xueli Shen.

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Shen, X., Jia, L.H., Zhao, P. et al. Changes in blood oxidative and antioxidant parameters in a group of Chinese patients with age-related macular degeneration. J Nutr Health Aging 16, 201–204 (2012). https://doi.org/10.1007/s12603-011-0350-8

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  • DOI: https://doi.org/10.1007/s12603-011-0350-8

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