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Subtype lesions of neovascular age-related macular degeneration in Chinese patients

  • Clinical Investigation
  • Published:
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Abstract

Purpose

To identify the subtype frequency and clinical features of neovascular age-related macular degeneration (AMD) in Chinese patients.

Methods

From January 2003 to August 2006, we investigated prospectively 155 newly diagnosed patients with presumed neovascular AMD. Fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) were performed in both eyes of all patients. Subtype frequency and clinical features were recorded according to their angiograms.

Results

Three subtypes of lesion were noted, which were polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP) and mixed lesions. Of the 155 patients, 105 (67.7%) had choroidal neovascularization (CNV) of the typical type seen in AMD, 38 (24.5%) had PCV and seven (4.5%) had RAP. In five (3.2%) additional cases, mixed lesions were noted. In 38 cases (47 eyes) with PCV, the rates of subfoveal, juxtafoveal and extrafoveal lesion were respectively 29.8% (14 eyes), 8.5% (four eyes), and 61.7% (29 eyes), compared with 75.6%, 14.6% and 9.8% for CNV lesion (P < 0.01). The percentage of subfoveal lesion in PCV group was significantly lower than that in the CNV group (P < 0.01). The location of the RAP lesion was subfoveal in two (28.6%) eyes, juxtafoveal in three (42.9%) eyes and extrafoveal in two (28.6%) eyes. The five eyes with mixed lesions were all PCV coexisting with CNV at the same eye, and in all of the five cases, CNV was subfoveal while PCV was extrafoveal.

Conclusions

In this hospital-based study, PCV accounts for 24.5% of neovascular AMD and is the most common subtype, RAP is less frequent (4.5%), and mixed lesions are much less common in Chinese patients. PCV is least likely to involve the fovea in neovascular AMD.

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Acknowledgement

This study was supported by the Natural Science Foundation of Guangdong Province (grant no. 04009333) and the Research Fund of Guangdong Bureau of Chinese Medicine (grant no.20030086).

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Authors and Affiliations

  1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, 510060, People’s Republic of China

    Yan Liu, Feng Wen, Shizhou Huang, Guangwei Luo, Hong Yan, Zuhua Sun & Dezheng Wu

Authors
  1. Yan Liu
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  2. Feng Wen
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  3. Shizhou Huang
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  4. Guangwei Luo
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  5. Hong Yan
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  6. Zuhua Sun
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  7. Dezheng Wu
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Corresponding author

Correspondence to Feng Wen.

Additional information

The authors have no proprietary interest. This study was supported by the Natural Science Foundation of Guangdong Province (grant no. 04009333) and the Research Fund of Guangdong Bureau of Chinese Medicine (grant no.20030086).

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Liu, Y., Wen, F., Huang, S. et al. Subtype lesions of neovascular age-related macular degeneration in Chinese patients. Graefes Arch Clin Exp Ophthalmol 245, 1441–1445 (2007). https://doi.org/10.1007/s00417-007-0575-8

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  • DOI: https://doi.org/10.1007/s00417-007-0575-8

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