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Left ventricular dyssynchrony and abnormalities in wall motion, assessed by gated-SPECT as ischemic auxiliary markers

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Journal of Nuclear Cardiology Aims and scope

A Correction to this article was published on 13 February 2019

This article has been updated

Abstract

Introduction

Left ventricular dyssynchrony (LVD) quantified by gated myocardial perfusion studies (MPS), through phase analysis (PA), has shown controversial results in myocardial stunning.

Objectives

Assessment of LVD and regional wall motion abnormalities (RWMA) in normal and ischemic patients.

Methods

A cohort of 172 patients were studied. Summed Stress Score (SSS), Summed Resting Score (SRS), and Summed Difference Score (SDS) were evaluated. Group 1-patients with normal MPS (N = 133) and Group 2-patients with myocardial ischemia in the MPS (N = 39). LVD was evaluated through PA and RWM by visual analysis.

Results

SSS 0 vs 9.8 ± 3.9 P = .0001; SDS 0 vs 9.8 ± 3.9 P = .0001; SRS 0 vs 0 P = NS, in G1 and G2. Significant differences were found in LVD between G1 and G2, bandwidth 36 ± 14 vs 63 ± 46 P = .0001; standard deviation 16 ± 10 vs 26 ± 15 P = .0001. In G1, 16% had LVD vs RWMA in 0%, P = .0001 and in G2, 59% with LVD vs 33% with RWMA, P = .03. Sensitivity for LVD 59% and for RWMA 33%, P = .03 and specificity for LVD 83% and for RWMA 100%, P = .0001.

Conclusion

Ischemic patients have LVD post-stress due to myocardial stunning. LVD measured by PA could be a useful tool to identify ischemia.

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Change history

  • 13 February 2019

    In Figure 3, sensitivity and specificity were interchanged. The corrected Figure 3 is shown below. The author names listed in reference 14 have been corrected; the correct reference reads: Nakanishi R, Gransar H, Slomka P, Arsanjani R, Shalev A, Otaki Y, et al. Predictors of high-risk coronary artery disease in subjects with normal SPECT myocardial perfusion imaging. J Nucl Cardiol 2016;23:530-41. The units of standard deviation (SD) and bandwidth (BW) in the abstract, results and in table 3 are expressed in degrees from 0 to 360°.

Abbreviations

LVD:

Left ventricular dyssynchrony

PA:

Phase analysis

MPS:

Myocardial perfusion study

RWMA:

Regional wall motion abnormalities

SSS:

Summed stress score

SRS:

Summed resting score

SDS:

Summed difference score

CAD:

Coronary artery disease

BW:

Bandwidth

K:

Kurtosis

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There are no conflicts of interest between the authors.

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Authors and Affiliations

  1. Department of Nuclear Cardiology, Hospital Italiano de La Plata, La Plata, Argentina

    Jorge Camilletti MD, Juan Erriest MD, Mónica Redolatti MD, Luis Cartasegna MD, Víctor Arregui MD & Gustavo Vigo MD

  2. Departament of Nuclear Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No 1, Colonia Sección XVI, Del. Tlalpan, 14080, Mexico City, Mexico

    Nilda Espinola-Zavaleta MD, PhD, Salvador Hernández-Sandoval MD, MsCs & Erick Alexanderson-Rosas MD

  3. Department of Physiology, Medicine Faculty, UNAM, Mexico City, Mexico

    Erick Alexanderson-Rosas MD

Authors
  1. Jorge Camilletti MD
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  2. Juan Erriest MD
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  3. Nilda Espinola-Zavaleta MD, PhD
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  4. Salvador Hernández-Sandoval MD, MsCs
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  5. Mónica Redolatti MD
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  6. Luis Cartasegna MD
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  7. Víctor Arregui MD
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  8. Gustavo Vigo MD
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  9. Erick Alexanderson-Rosas MD
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Corresponding author

Correspondence to Erick Alexanderson-Rosas MD.

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Camilletti, J., Erriest, J., Espinola-Zavaleta, N. et al. Left ventricular dyssynchrony and abnormalities in wall motion, assessed by gated-SPECT as ischemic auxiliary markers. J. Nucl. Cardiol. 27, 2261–2268 (2020). https://doi.org/10.1007/s12350-018-01544-4

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