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Assessment of an intermediate reprojection technique transitioning from planar to SPECT radionuclide ventriculography

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

The technique of SPECT-RNV (radionuclide ventriculography) offers a greater amount of clinically usable data than its planar counterpart (P-RNV). In transitioning from planar to SPECT-only acquisition methodologies, reprojection of the SPECT data can provide a planar dataset which can be used as an interim technique. The aim of this study was to test if reprojected planar images could be used as a surrogate for true planar images in SPECT-only setting.

Methods

We performed SPECT-RNV and P-RNV on 47 patients on traditional sodium iodide (NaI) cameras, determining left ventricular ejection fractions (LVEF) for planar (EFP) and SPECT (EFS) techniques. We reprojected the SPECT-RNV data along the best septal separation angle determined from planar scanning. This creates a further planar dataset denoted ‘reprojected P-RNV’ (rP-RNV) giving a reprojected ejection fraction (EFR) which can be used as a validation variable in transitioning to SPECT-only acquisition.

Results

Performing t tests showed no statistical difference between EFP and EFR (P > .017) but bias was observed in EFS results compared to EFP and EFS compared to EFR results. An unblinded, comparison of parametric data between the three datasets for a subset of ten patients showed good clinical concordance. False negative and false positive rates were low for rP-RNV compared to P-RNV.

Conclusions

The reprojected planar LVEF correlates well to P-RNV EF values. The rP-RNV dataset can aid clinicians in transitioning from planar RNV to SPECT-only acquisition.

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Acknowledgments

The authors are grateful to the radiography staff at the Department of Nuclear Medicine, Royal Brompton Hospital for their help in data collection. JOD acknowledges financial support from the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy’s & St Thomas’ NHS Foundation Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust and The Centre of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC under Grant Number WT 088641/Z/09/Z. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, the DoH, EPSRC, or Wellcome Trust.

Disclosure

The authors have nothing to disclose.

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Authors and Affiliations

  1. PET Imaging Centre, Division of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ Hospital, London, SE1 7EH, United Kingdom

    Jim O’Doherty CSci, PhD

  2. Department of Nuclear Medicine, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, United Kingdom

    Bruno Rojas Fisher CSci, MSc, Jonathan Mark Price MSc & Kshama Wechalekar MBBS, DRM, DNB (Nuclear Medicine)

  3. Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, Institute of Cancer Research, Sutton, SM2 5NG, United Kingdom

    Jonathan Mark Price MSc

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  1. Jim O’Doherty CSci, PhD
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  2. Bruno Rojas Fisher CSci, MSc
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  3. Jonathan Mark Price MSc
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  4. Kshama Wechalekar MBBS, DRM, DNB (Nuclear Medicine)
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Correspondence to Jim O’Doherty CSci, PhD.

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O’Doherty, J., Rojas Fisher, B., Price, J.M. et al. Assessment of an intermediate reprojection technique transitioning from planar to SPECT radionuclide ventriculography. J. Nucl. Cardiol. 21, 944–953 (2014). https://doi.org/10.1007/s12350-014-9945-x

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  • DOI: https://doi.org/10.1007/s12350-014-9945-x

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