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Gated tomographic radionuclide angiography using cadmium-zinc-telluride detector gamma camera; comparison to traditional gamma cameras

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Journal of Nuclear Cardiology Aims and scope

Abstract

Purpose

Estimation of left ventricular ejection fraction (LVEF) with equilibrium 99MTc-HSA equilibrium radionuclide angiography (MUGA) is frequently used for assessing cardiac function. The purpose of this study was to compare intra- and interobserver variation between three different gamma cameras.

Materials and Methods

Eighty-two patients, scanned in the same sequential order on the three cameras. Each acquisition was analyzed twice by two technologists. Inter- and intraobserver variations were calculated as the coefficient of variation and the 95% confidence interval for limits of agreement between each sequence of analyses for each of the three cameras.

Results

The lowest intraobserver variations in LVEF for the two NaI-detector cameras were 3.1% (−4.0% to 3.5%) for the planar and 3.4% (−4.2% to 4.5%) for SPECT (P ≤ 0.001-0.019), the highest result for the CZT SPECT camera was 2.6% (−2.9% to 3.1%). Similarly, interobserver variation was 4.8% (−4.8% to 6.4%) and 4.9% (−5.4% to 7.5%), respectively, for each of the NaI-detector cameras and 3.3% (−3.4% to 4.3%) for the CZT SPECT camera (P ≤ 0.001-0.008).

Discussion

The CZT detector camera was superior to both NaI detector cameras regarding intra- and interobserver variation. The CZT SPECT camera may identify changes in LVEF with greater certainty than its NaI detector-equipped counterparts.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Herlev, Herstedvesterstræde 54, 2620, Albertslund, Denmark

    Maria Maj Jensen MD & Bo Zerahn MD

  2. Department of Endocrinology, Copenhagen University Hospital Herlev, Herlev, Denmark

    Ulla Schmidt MD

  3. University of Copenhagen, Köbenhavn K, Denmark

    Chenxi Huang MS

Authors
  1. Maria Maj Jensen MD
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  2. Ulla Schmidt MD
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  3. Chenxi Huang MS
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  4. Bo Zerahn MD
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Correspondence to Maria Maj Jensen MD.

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Jensen, M.M., Schmidt, U., Huang, C. et al. Gated tomographic radionuclide angiography using cadmium-zinc-telluride detector gamma camera; comparison to traditional gamma cameras. J. Nucl. Cardiol. 21, 384–396 (2014). https://doi.org/10.1007/s12350-013-9844-6

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  • DOI: https://doi.org/10.1007/s12350-013-9844-6

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