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Gated blood-pool SPECT versus cardiac magnetic resonance imaging for the assessment of left ventricular volumes and ejection fraction

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

We evaluated the accuracy of planar radionuclide angiography and different count-based and space-based electrocardiogram (ECG)-gated blood-pool single-photon emission computed tomography (GBPS) algorithms for assessment of left ventricular end-diastolic volume (LVEDV), end-systolic volume (LVESV), and ejection fraction (LVEF) compared with the gold standard of cardiac magnetic resonance imaging (cMRI). The goal is to assess the accuracy of a recently developed GBPS algorithm.

Methods and Results

Subjects had planar, GBPS, and cMRI sequentially. Datasets were processed by QBS software (Cedar-Sinai) and by MHI software (Montreal Heart Institute). Space-based approaches were used to compute LVEDV, LVESV, and LVEF. Count-based techniques were also used to assess LVEF. All results were compared to cMRI. Fifty-five patients (85% male; mean age 63 ± 9 years) completed the study. LVEFs and their correlations to cMRI values were 43 ± 12% (r = .82), 39 ± 14% (r = .82), and 39 ± 13% for MHIspace, QBSspace, and cMRI methodologies, respectively. LVEF by count-based methods also demonstrated good correlation to LVEF provided by cMRI (42 ± 13%, r = .88 for MHIcount and 46 ± 15%, r = .84 for QBScount). Strong correlations were obtained for LVEDV (r = .96 for MHI and r = .92 for QBS) and for LVESV (.97 for MHI and r = .94 for QBS).

Conclusions

All Gated blood-pool SPECT algorithms had significant variation in estimating LVEF. Nevertheless our software provides good estimates of LV volumes and LVEF. Such software may, therefore, be applied to assess LV morphology and function.

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Acknowledgement

This work was supported in part by the “Fonds de la Recherche en Santé du Québec” and by a Canada Research Chair.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Montreal Heart Institute and University of Montréal, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada

    François Harel MD, BEng, Vincent Finnerty MSc & Jean Grégoire MD

  2. Department of Medicine, Montreal Heart Institute and University of Montréal, Montreal, QC, Canada

    Bernard Thibault MD, François Marcotte MD & Paul Khairy MD, PhD

  3. Department of Radiology, Montreal Heart Institute and University of Montréal, Montreal, QC, Canada

    Patricia Ugolini MD

Authors
  1. François Harel MD, BEng
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  2. Vincent Finnerty MSc
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  3. Jean Grégoire MD
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  4. Bernard Thibault MD
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  5. François Marcotte MD
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  6. Patricia Ugolini MD
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  7. Paul Khairy MD, PhD
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Corresponding author

Correspondence to François Harel MD, BEng.

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Harel, F., Finnerty, V., Grégoire, J. et al. Gated blood-pool SPECT versus cardiac magnetic resonance imaging for the assessment of left ventricular volumes and ejection fraction. J. Nucl. Cardiol. 17, 427–434 (2010). https://doi.org/10.1007/s12350-010-9195-5

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  • DOI: https://doi.org/10.1007/s12350-010-9195-5

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