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Consensus Paper: Current Views on the Role of Cerebellar Interpositus Nucleus in Movement Control and Emotion

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Abstract

In the present paper, we examine the role of the cerebellar interpositus nucleus (IN) in motor and non-motor domains. Recent findings are considered, and we share the following conclusions: IN as part of the olivo-cortico-nuclear microcircuit is involved in providing powerful timing signals important in coordinating limb movements; IN could participate in the timing and performance of ongoing conditioned responses rather than the generation and/or initiation of such responses; IN is involved in the control of reflexive and voluntary movements in a task- and effector system-dependent fashion, including hand movements and associated upper limb adjustments, for quick effective actions; IN develops internal models for dynamic interactions of the motor system with the external environment for anticipatory control of movement; and IN plays a significant role in the modulation of autonomic and emotional functions.

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Acknowledgments

R. Apps and N. Cerminara gratefully acknowledge the support of the Medical Research Council and the Biotechnology and Biological Sciences Research Council. V. Bracha and A. J. Carrel would like to thank Gary Zenitsky for his help in manuscript preparation; supported by NIH Grant R01-NS-036210. J. M. Delgado-García, R. Sánchez-Campusano and A. Gruart thank grants MICINN-BFU2008-0899, P07-CVI-2487 and JA-BIO-122 to JMDG, and MICINN-BFU2008-03390 and P07-CVI-02686 to AG. Also, we thank Roger Churchill for his editorial help. V. Perciavalle and M. Coco are grateful to students, postdoctoral fellows and colleagues, in particular to Gianfranco Bosco, Antonino Casabona and Maria Stella Valle, whose research and ideas contributed to the content of their contribution. M. Leggio acknowledges the support of the Italian Ministry of Health (grant RC11.G) and of the Santa Lucia Foundation.

Conflicts of interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Bio-Medical Sciences, Section of Physiology, University of Catania, Viale Andrea Doria 6, 95125, Catania, Italy

    Vincenzo Perciavalle & Marinella Coco

  2. School of Physiology and Pharmacology, University of Bristol, Bristol, UK

    Richard Apps & Nadia Cerminara

  3. Biomedical Sciences Department, Iowa State University, Ames, IA, USA

    Vlastislav Bracha & Andrew J. Carrel

  4. Division of Neurosciences, Pablo de Olavide University, Seville, Spain

    José M. Delgado-García, Agnès Gruart & Raudel Sánchez-Campusano

  5. Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USA

    Alan R. Gibson

  6. Department of Psychology, University of Rome “La Sapienza”, Rome, Italy

    Maria Leggio

  7. Santa Lucia Foundation IRCCS, Rome, Italy

    Maria Leggio

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  1. Vincenzo Perciavalle
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  2. Richard Apps
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  3. Vlastislav Bracha
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  4. José M. Delgado-García
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  6. Maria Leggio
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  9. Marinella Coco
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  10. Agnès Gruart
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  11. Raudel Sánchez-Campusano
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Correspondence to Vincenzo Perciavalle.

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Perciavalle, V., Apps, R., Bracha, V. et al. Consensus Paper: Current Views on the Role of Cerebellar Interpositus Nucleus in Movement Control and Emotion. Cerebellum 12, 738–757 (2013). https://doi.org/10.1007/s12311-013-0464-0

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