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Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics

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An Erratum to this article was published on 11 February 2017

Abstract

Various approaches have been proposed for point-of-care diagnostics, and in particular, optical detection is preferred because it is relatively simple and fast. At the same time, field-effect transistor (FET)-based biosensors have attracted great attention because they can provide highly sensitive and label-free detection. In this work, we present highly sensitive, epidermal skin-type point-of-care devices with system-level integration of flexible MoS2 FET biosensors, read-out circuits, and light-emitting diode (LEDs) that enable real-time detection of prostate cancer antigens (PSA). Regardless of the physical forms or mechanical stress conditions, our proposed high-performance MoS2 biosensors can detect a PSA concentration of 1 pg·mL–1 without specific surface treatment for anti-PSA immobilization on the MoS2 surface on which we characterize and confirm physisorption of anti-PSA using Kelvin probe force microscopy (KPFM) and tapping-mode atomic force microscopy (tm-AFM). Furthermore, current modulation induced by the binding process was stably maintained for longer than 2–3 min. The results indicate that flexible MoS2-based FET biosensors have great potential for point-of-care diagnostics for prostate cancer as well as other biomarkers.

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Acknowledgements

This research was supported in part by the National Research Foundation of Korea (Nos. NRF-2014M3A9 D7070732, and NRF-2015R1A5A1037548). This research was supported by the Commercializations Promotion Agency for R&D Outcomes (COMPA) funded by the Ministry of Science, ICT and Future Planning (MISP).

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Authors and Affiliations

  1. School of Electronic Engineering, Soongsil University, Seoul, 06978, Republic of Korea

    Geonwook Yoo

  2. Multi-Functional Nano/Bio Electronics Lab., Kyung Hee University, Gyeonggi, 17104, Republic of Korea

    Heekyeong Park, Minjung Kim, Won Geun Song, Seokhwan Jeong, Young Ki Hong & Sunkook Kim

  3. Department of Biomedical Engineering, Yonsei University, Wonju, 26493, Republic of Korea

    Min Hyung Kim, Hyungbeen Lee & Sang Woo Lee

  4. Korea Electronics Technology Institute, Gyeonggi, 13488, Republic of Korea

    Min Goo Lee & Sungho Lee

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  1. Geonwook Yoo
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  2. Heekyeong Park
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  3. Minjung Kim
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  4. Won Geun Song
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  7. Hyungbeen Lee
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  8. Sang Woo Lee
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  9. Young Ki Hong
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  10. Min Goo Lee
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  11. Sungho Lee
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  12. Sunkook Kim
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Corresponding authors

Correspondence to Sungho Lee or Sunkook Kim.

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These authors contributed equally to this work.

An erratum to this article is available at http://dx.doi.org/10.1007/s12274-017-1499-1.

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Yoo, G., Park, H., Kim, M. et al. Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics. Nano Res. 10, 767–775 (2017). https://doi.org/10.1007/s12274-016-1289-1

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  • DOI: https://doi.org/10.1007/s12274-016-1289-1

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