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Nanomaterial-Based Surface Plasmon Resonance Sensing Chip for Detection of Skin and Breast Cancer

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Abstract

Today’s advancements in technology in modern-day life have substantially raised the significance of surface plasmon resonance (SPR) sensors. In order to enhance the sensor’s performance, experts are now focused on developing a SPR biomedical sensor that integrates a prism with a thin nanocomposite layer. The proposed SPR biosensor has been built with silver, BaTiO3, and 2D layering of materials (MoSe2/WS2) for the purpose to identifying skin and breast cancer cells. In this analysis, the attenuated total reflection (ATR) technique of SPR is used for the detection of skin cancer (basal cell) and breast cancer cells (MM-231 and MCF-7) to evaluate the results. It is being observed that by utilizing two metallic silver coatings with a thickness of 50 nm and 10 nm. The effectiveness of the device can be improved with two layers of WS2 (each of 0.5 nm) and two layers of BaTiO3 (each of 5 nm); the highest sensitivity can be achieved in the case of skin cancer. The numerical findings show that the basal cell’s highest sensitivity is 253.5 (°/RIU) and breast (MM-231 and MCF-7) cancer cells are 309.2857°/RIU and 295.71°/RIU. The figure of merit (FoM), detection accuracy (DA), and signal-to-noise ratio (SNR) are 146.11 (RIU−1), 0.576 (degree−1), and 2.922, respectively, for basal cells, and for breast cancer, 255.66 (RIU−1), 0.829 (degree−1), and 3.59 are realized. Lastly, the numerical outcomes derived in this manuscript revealed a high degree of sensitivity and FoM compared to those of previous research studies.

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Data Availability

Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

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Funding

This work is carried out from a research grant under project reference no. SCP/2022/000271 dated 08/08/2022 funded by the Science and Engineering Research Board, Department of Science and Technology, Government of India, with the project entitled “Design of a web server-based hybrid physiological sensor with optical cloth for real-time health specialist care.” The work of Santosh Kumar was supported by the Double-Hundred Talent Plan of Shandong Province, China and Liaocheng University (318052341).

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Authors and Affiliations

  1. Optical Sensor Laboratory, Dept. of Electronics Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad, Jharkhand, 826004, India

    Vikash Kumar & Sanjeev Kumar Raghuwanshi

  2. Department of Electrical Engineering, GLA University, Mathura, Uttar Pradesh, 281406, India

    Vikash Kumar

  3. Shandong Key Laboratory of Optical Communication Science and Technology, School of Physics Science and Information Technology, Liaocheng University, Liaocheng, 252059, China

    Santosh Kumar

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  1. Vikash Kumar
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Contributions

Vikash Kumar: conceptualization, data curation, formal analysis, and investigation, resources and software, visualization and writing original draft; Sanjeev Kumar Raghuwanshi: conceptualization, supervision and validation; Santosh Kumar: data curation, formal analysis, and investigation, visualization and writing original draft.

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Correspondence to Sanjeev Kumar Raghuwanshi.

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Kumar, V., Raghuwanshi, S.K. & Kumar, S. Nanomaterial-Based Surface Plasmon Resonance Sensing Chip for Detection of Skin and Breast Cancer. Plasmonics 19, 643–654 (2024). https://doi.org/10.1007/s11468-023-02022-5

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