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Myriocin induces apoptotic lung cancer cell death via activation of DR4 pathway

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Abstract

It has been known that myriocin inhibits melanoma growth. However, the effects and action mechanisms of myriocin on lung cancer cell growth have not been reported. In this study, we examined whether myriocin isolated from Mycelia sterilia inhibits cell growth of lung cancer cells (A549 and NCI-H460) as well as possible signaling pathways involved in cell growth inhibition. Different concentrations of myriocin inhibited the growth of lung cancer cells through the induction of apoptotic cell death. Consistent with cancer cell growth inhibition, myriocin induced the expression of death receptors (DRs) as well as p-JNK and p-p38 in both cell lines. Moreover, the combination of myriocin with DR4 ligand TRAIL, and other well known anti-tumor drugs (docetaxel and cisplatin) synergistically inhibited cancer cell growth, and induced DR4 expression. These results showed that myriocin inhibits lung cancer cells growth through apoptosis via the activation of DR4 pathways, and enhanced anti-cancer effects with well known drugs. Thus, our study indicates that myriocin could be effective for lung cancer cells as an anti-cancer drug and/or a conjunction agent with well known anti-cancers.

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Acknowledgments

This work was supported by the research grant of Chungbuk National University in 2012.

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The authors declare that they have no competing interests.

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Authors and Affiliations

  1. College of Pharmacy and Medical Research Center, Chungbuk National University, 48, Gaeshin-dong, Heungduk-gu, Cheongju, 361-763, Chungbuk, Korea

    Kyung Eun Choi, Young Suk Jung, Dea Hwan Kim, Ju Kyung Song, Ji Young Kim, Yu Yeon Jung, So Young Eum, Hwan Soo Yoo, Sang-Bae Han & Jin Tae Hong

  2. Osong Health Technology Administration Complex, 187 Osongsaengmyeong2(i)-ro, Osong-eup, Cheongwon-gun, Chungbuk, 363-700, Korea

    Joo Hwan Kim & Na Young Yoon

  3. College of Pharmacy, Chungbuk National University, 12, Gaeshin-dong, Heungduk-gu, Cheongju, Chungbuk, 361-763, Korea

    Jin Tae Hong

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  1. Kyung Eun Choi
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Choi, K.E., Jung, Y.S., Kim, D.H. et al. Myriocin induces apoptotic lung cancer cell death via activation of DR4 pathway. Arch. Pharm. Res. 37, 501–511 (2014). https://doi.org/10.1007/s12272-013-0315-z

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