Abstract
Based on fluorine switch approach, a series of 3′-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. Direct reduction of β-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3′-fluoropenciclovir analogues. The synthesized 3′-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, HSV-1, HSV-2 and HIV.
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Choi, MH., Lee, CK. & Kim, HD. Design and synthesis of 3′-fluoropenciclovir analogues as antiviral agents. Arch. Pharm. Res. 33, 197–202 (2010). https://doi.org/10.1007/s12272-010-0202-9
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DOI: https://doi.org/10.1007/s12272-010-0202-9