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Roles of NG2 Glia in Cerebral Small Vessel Disease

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Abstract

Cerebral small vessel disease (CSVD) is one of the most prevalent pathologic processes affecting 5% of people over 50 years of age and contributing to 45% of dementia cases. Increasing evidence has demonstrated the pathological roles of chronic hypoperfusion, impaired cerebral vascular reactivity, and leakage of the blood–brain barrier in CSVD. However, the pathogenesis of CSVD remains elusive thus far, and no radical treatment has been developed. NG2 glia, also known as oligodendrocyte precursor cells, are the fourth type of glial cell in addition to astrocytes, microglia, and oligodendrocytes in the mammalian central nervous system. Many novel functions for NG2 glia in physiological and pathological states have recently been revealed. In this review, we discuss the role of NG2 glia in CSVD and the underlying mechanisms.

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Acknowledgements

This review was supported by grants from the National Natural Science Foundation of China (32100798) and the China Postdoctoral Science Foundation (2021M700821). We thank LetPub (www.letpub.com) for linguistic assistance during the preparation of this manuscript.

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Author notes

  1. Yixi He and Zhenghao Li contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

    Yixi He, Jing Ding & Xin Wang

  2. State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China

    Yixi He, Xiaoyu Shi, Jing Ding & Xin Wang

  3. Institute of Neuroscience, MOE Key Laboratory of Molecular Neurobiology, NMU, Shanghai, 200433, China

    Zhenghao Li

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  1. Yixi He
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He, Y., Li, Z., Shi, X. et al. Roles of NG2 Glia in Cerebral Small Vessel Disease. Neurosci. Bull. 39, 519–530 (2023). https://doi.org/10.1007/s12264-022-00976-w

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