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Association of Genetic Polymorphisms in HSD17B1, HSD17B2 and SHBG Genes with Hepatocellular Carcinoma Risk

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Pathology & Oncology Research

Abstract

Genetic polymorphisms of enzymes involved in estrogen synthesizing/transporting can influence the risk of hormone-dependent diseases. The incidence rate and relative risk for hepatocellular carcinoma (HCC) are higher in men than in women. This study was conducted to explore the relationship of single nucleotide polymorphisms (SNPs) in 17 β-Hydroxysteroid dehydrogenases (HSD17B1 and HSD17B2) and sex hormone-binding globulin (SHBG) genes with the risk of HCC within Chinese Han population. Polymorphisms of HSD17B1 rs676387, HSD17B2 rs8191246 and SHBG rs6259 were genotyped in 253 HCC patients and 438 healthy control subjects using the polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). Significantly increased HCC risk was found to be associated with T allele of rs676387 and G allele of rs8191246. Increased HCC risks were found in different genetic model (TT genotype in a recessive model, T allele carriers in a dominant model, TT genotype and TG genotype in a codominant model for HSD17B1 rs676387, G allele carriers in a dominant model and AG genotype in a codominant model for HSD17B2 rs8191246, respectively). No association between SHBG rs6259 and HCC risk was observed. The present study provided evidence that HSD17B1 rs676387 and HSD17B2 rs8191246 were association with HCC development. Further studies in diverse ethnic population with larger sample size were recommended to confirm the findings.

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Acknowledgments

This study was financially supported by the Undergraduate Innovative Experiment Plan of Cheng Du Medical College (Grant No: CXJS201302) and Fund Project of Sichuan Provincial Department of Education (Grant No:13ZB0233).

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The authors have declared that no conflict of interest exists.

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Authors and Affiliations

  1. Department of Pathology and Pathophysiology, Cheng Du Medical College, Chengdu, 610500, China

    Lu Shun Zhang, Juan Li, Xin Lian Liu, Jing Sun & Feng Mei Deng

  2. Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, China

    Fang Yuan

  3. Department of Experimental Technology, Chengdu Medical College, Chengdu, 610500, China

    Xuan Guan

  4. Department of Lab Medicine, Cheng Du Medical College, Chengdu, 610500, China

    Bo Liu & Wei Ma

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  1. Lu Shun Zhang
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Correspondence to Lu Shun Zhang or Feng Mei Deng.

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Zhang, L.S., Yuan, F., Guan, X. et al. Association of Genetic Polymorphisms in HSD17B1, HSD17B2 and SHBG Genes with Hepatocellular Carcinoma Risk. Pathol. Oncol. Res. 20, 661–666 (2014). https://doi.org/10.1007/s12253-014-9746-1

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  • DOI: https://doi.org/10.1007/s12253-014-9746-1

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