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Association Between Single Nucleotide Polymorphisms of Sterol Regulatory Element Binding Protein-2 and Liver X Receptor α Gene and Risk of Polycystic Ovary Syndrome in a Chinese Han Population

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Abstract

To investigate associations of single nucleotide polymorphisms (SNPs) rs2228314 of sterol regulatory element-binding protein-2 (SREBP-2) or rs11039155 of liver X receptor α (LXRα) with susceptibility to polycystic ovary syndrome (PCOS) in a Chinese Han population. SREBP-2 rs2228314 and LXRα rs11039155 polymorphisms were genotyped in patients with PCOS and age- and sex-matched PCOS-free controls from a Chinese Han population. A total of 605 patients with PCOS and 615 controls were recruited in this study. We found that GC and CC genotypes of rs2228314, and variant C, were associated with a significantly increased risk of PCOS. In addition, GA and AA genotypes of rs11039155, as well as variant A, were also associated with a significantly increased risk of PCOS. Our results showed that SREBP-2 rs2228314 G to C change and variant C genotype as well as LXRα rs11039155 G to A change and variant A may contribute to PCOS in Chinese Han population.

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Acknowledgments

This work was funded by grants from Hangzhou Science and Technology Committee Research Project (No. 20130733Q10).

Conflict of interest

The authors declare that there are no conflicts of interest.

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Authors and Affiliations

  1. Department of gynaecology and obstetrics, Hangzhou Red Cross Hospital, Hangzhou, 310003, Zhejiang Province, China

    Jianhong Zhao, Zhiying Hu, Ling Liu, Xijing Jiang & Linzhen Wu

  2. Central laboratory, Hangzhou Red Cross Hospital, Hangzhou, 310003, Zhejiang Province, China

    Long Cai

  3. Department of gynaecology, Linyi People’s Hospital, Linyi City, 276000, China

    Junling Gong

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  1. Jianhong Zhao
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  2. Zhiying Hu
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  3. Long Cai
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  4. Ling Liu
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  6. Linzhen Wu
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  7. Junling Gong
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Correspondence to Junling Gong.

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Zhao, J., Hu, Z., Cai, L. et al. Association Between Single Nucleotide Polymorphisms of Sterol Regulatory Element Binding Protein-2 and Liver X Receptor α Gene and Risk of Polycystic Ovary Syndrome in a Chinese Han Population. Cell Biochem Biophys 70, 1421–1426 (2014). https://doi.org/10.1007/s12013-014-0075-5

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