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Polymorphisms in genes HSD17B1 and HSD17B2 and uterine leiomyoma risk in Chinese women

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the association of HSD17B1 and HSD17B2 gene polymorphisms with uterine leiomyoma in Chinese women.

Methods

121 Chinese women with clinically diagnosed uterine leiomyoma and 217 healthy normal Chinese women were investigated to compare three single nucleotide polymorphisms (SNPs) (rs605059 and rs676387 of HSD17B1 gene and rs8191246 of HSD17B2 gene) by polymerase chain reaction–restriction fragment length polymorphism and DNA sequencing method.

Results

All the SNPs were polymorphisms in Chinese women. Frequencies of rs605059 AA genotype and A allele were significantly increased in patients with uterine leiomyoma compared to healthy controls (GG vs. AA, OR 0.40, 95 % CI 0.20–0.82; G vs. A, OR 0.68, 95 % CI 0.50–0.94).

Conclusion

The results suggest that the genotype of HSD17B1 rs605059 may play a role in the tumourgenesis of uterine leiomyoma.

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Acknowledgments

This work was financially supported by Opening Fund of Shanghai Key Laboratory of Forensic Medicine (Grant No. KF1002) and Research Fund for the Doctoral Program of Higher Education of China (Grant No. 200806101086).

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, China

    Rui-Juan Cong, Zheng Wang, Lagabaiyila Zha, Li-Ping Cao, Xiao-Wei Su, Jing Yan & Ying-Bi Li

  2. Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, 610041, China

    Zhong-Ying Huang

  3. Department of Laboratory Tests, Shuangluan People’s Hospital, Chengde, 067001, Hebei, China

    Ling Cong

  4. Department of Forensic Toxicological Analysis, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, China

    Yi Ye

  5. Shanghai Key Laboratary of Forensic Medicine, Shanghai, China

    Jing Yan

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  1. Rui-Juan Cong
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  2. Zhong-Ying Huang
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  3. Ling Cong
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Correspondence to Jing Yan or Ying-Bi Li.

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Cong, RJ., Huang, ZY., Cong, L. et al. Polymorphisms in genes HSD17B1 and HSD17B2 and uterine leiomyoma risk in Chinese women. Arch Gynecol Obstet 286, 701–705 (2012). https://doi.org/10.1007/s00404-012-2328-0

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  • DOI: https://doi.org/10.1007/s00404-012-2328-0

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