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Routes to cell death in animal and plant kingdoms: from classic apoptosis to alternative ways to die—a review

  • Current topics in Biology
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Abstract

Programmed cell death is fundamental for multicellular organisms either in animal or plant kingdom. Classic apoptosis, which represents the best studied form of cell death, is dependent on caspase protease activity in animals. These proteases are not present in plants, where caspase-like activities, including metacaspases, are involved in the execution of plant cell death. Beyond apoptosis, various non-apoptotic forms of cell death also exist, including autophagy, necroptosis, pyroptosis, and ferroptosis. These types of cell death can be activated independently of apoptosis and sometimes occur when apoptosis is inhibited. Non-apoptotic forms of cell death are best characterized in animals, whereas, in plants, the literature is less extensive, but the molecular executioners of plant cell death are becoming clearer. The aim of this review is to describe different types of cell death and the mechanisms involved in animals and plants, highlighting similarities and differences in the two kingdoms. Moreover, implications of cell death pathways in cancer are discussed.

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  1. Sonia Emanuele and Elisabetta Oddo have contributed equally to this work.

Authors and Affiliations

  1. Laboratory of Biochemistry, Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy

    Sonia Emanuele & Marianna Lauricella

  2. Laboratory of Plant Biology and Conservation, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Via Archirai 20, 90100, Palermo, Italy

    Elisabetta Oddo

  3. Laboratory of Biochemistry, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Policlinico, Via del Vespro 129, 90127, Palermo, Italy

    Antonella D’Anneo, Antonietta Notaro, Giuseppe Calvaruso & Michela Giuliano

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  1. Sonia Emanuele
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This paper belongs to a series of peer-reviewed contributions coordinated by Guest Editor Ferdinando Palmieri on the theme "Current topics in biology".

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Emanuele, S., Oddo, E., D’Anneo, A. et al. Routes to cell death in animal and plant kingdoms: from classic apoptosis to alternative ways to die—a review. Rend. Fis. Acc. Lincei 29, 397–409 (2018). https://doi.org/10.1007/s12210-018-0704-9

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